Triple therapy does not reduce COPD exacerbations
The addition of tiotropium does not reduce COPD exacerbations.
HealthDay News — The addition of tiotropium to long-acting β2-agonists (LABA) and/or inhaled corticosteroids (ICS) does not reduce chronic obstructive pulmonary disease (COPD) exacerbations compared to LABA/ICS alone, according to a study published online April 20 in the Journal of Clinical Pharmacology.
Eliana Ferroni, MD, from the Lazio Regional Health Service in Rome, and colleagues used administrative data to identify 5,717 adults hospitalized for COPD (from 2006 to 2009) who were newly prescribed a fixed LABA/ICS combination (double therapy) or tiotropium as part of triple therapy.
The researchers found that 31.9% initiated LABA/ICS as part of triple therapy. The adjusted hazard ratios (HRs) for moderate, severe, and any exacerbations were 1.02 (95% confidence interval [CI], 0.89 to 1.16), 0.92 (95% CI, 0.76 to 1.12) and 1.08 (95% CI, 0.91 to 1.28), respectively, in intention-to-treat analysis. Similar results were seen when adjusting for propensity scores. Triple therapy was significantly associated with reduced risk of moderate exacerbations, compared to double therapy (HR, 0.68; 95% CI, 0.48 to 0.98), in an intention-to-treat approach among a sub-cohort of patients with previous exacerbations.
"Given the impact of exacerbations on health status and prognosis, it is crucial to target COPD patients for optimal treatment," the authors write.
- Ferroni E, Belleudi V, Cascini S, et al. Role of tiotropium in reducing exacerbations of chronic obstructive pulmonary disease when combined with long-acting β2-agonists and inhaled corticosteroids: the OUTPUL study. J Clin Pharmacol. 2016; doi: 10.1001/jcph.750