Indications for: EMEND

In combination with other antiemetic agents, in patients ≥12yrs of age for prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately to highly emetogenic cancer chemotherapy, including high-dose cisplatin.

Adult Dosage:

Swallow caps whole. Chemotherapy induced: ≥12yrs: give with corticosteroid and 5-HT3 antagonist (see full labeling). 125mg on Day 1; then 80mg on Days 2 and 3. Administer caps 1 hr prior to chemotherapy on Days 1, 2, and 3; if no chemotherapy is given on Days 2 and 3, then administer caps in the AM.

Children Dosage:

Chemotherapy induced: <12yrs: use oral susp.

EMEND Contraindications:

Concomitant pimozide.

EMEND Warnings/Precautions:

Not for chronic continuous use. Severe hepatic impairment. Injection: monitor for infusion site or hypersensitivity reactions; discontinue and treat appropriately if occur; do not reinitiate if symptoms (eg, flushing, erythema, dyspnea, hypotension, syncope) develop with first-time use. Avoid infusion into small veins or through a butterfly catheter. Elderly. Advise females of reproductive potential using hormonal contraceptives to use an effective alternative or back-up non-hormonal contraceptive (see Interactions). Pregnancy. Nursing mothers.

EMEND Classification:

Substance P/NK1 receptor antagonist.

EMEND Interactions:

See Contraindications. Monitor, and caution with, CYP3A4 substrates, including chemotherapy agents (eg, ifosfamide, vinblastine, vincristine). Avoid concomitant moderate-to-strong CYP3A4 inhibitors (eg, azole antifungals, macrolides, nefazodone, ritonavir, nelfinavir, diltiazem) or strong CYP3A4 inducers (eg, carbamazepine, phenytoin, rifampin). Potentiates dexamethasone (reduce its dose by 50%), methylprednisolone (reduce its IV dose by 25% and its oral dose by 50%), midazolam, alprazolam, triazolam. May antagonize warfarin (closely monitor INR for 2 weeks after starting each regimen), other CYP2C9 substrates, oral contraceptives (use alternative or backup method during and for 1 month after last dose).

Adverse Reactions:

Fatigue, diarrhea, asthenia, dyspepsia, abdominal pain, hiccups, WBC count decreased, dehydration, ALT/AST increased, neutropenia, headache, anorexia, cough, hemoglobin decreased, dizziness, constipation, hypotension. Injection: also anemia, peripheral neuropathy, UTI, extremity pain, infusion-site reactions, anaphylaxis.

Generic Drug Availability:


How Supplied:

Caps—6; Bi-fold pack (2 x 80mg)—1; Tri-fold pack (1 x 125mg + 2 x 80mg)—1; Susp kit—1 (w. oral dispensers, supplies); Single-dose vial—1

Pricing for EMEND

40mg capsule (Qty: 1)
Appx. price $40