Colorectal disorders:

Indications for ENTEREG:

To accelerate the time to upper and lower gastrointestinal recovery following surgeries that include partial bowel resection surgery with primary anastomosis.

Adult:

Give 12mg 30mins to 5hrs before surgery, then 12mg twice daily starting on 1st post-op day until hospital discharge for up to 7 days; max 15 doses.

Children:

Not established.

Contraindications:

Opioid use, at therapeutic doses, for >7 consecutive days prior.

Boxed Warning:

Potential risk of MI with long-term use: for short-term hospital use only.

Warnings/Precautions:

For short-term hospital use only. Potential risk of MI with long-term use. Severe hepatic impairment, ESRD, complete GI obstruction, pancreatic or gastric anastomosis: not recommended. Mild-to-severe renal impairment or mild-to-moderate hepatic impairment: monitor closely; discontinue if adverse reactions occur. Recent (within week prior to surgery) use of >3 doses of opioids; monitor for GI events. Japanese patients (monitor). Pregnancy (Cat.B). Nursing mothers.

Pharmacologic Class:

Opioid antagonist (peripheral).

Adverse Reactions:

Dyspepsia.

Note:

Available only to hospitals that enroll in Entereg Access Support and Education Program (EASE). For more information, and to enroll, call (877) 282-4786.

REMS:

YES

How Supplied:

Caps—30

Pricing for ENTEREG

12mg capsule (Qty: 10)
Appx. price $1643
GoodRx