CNS cancers:
Indications for: GLIADEL
Newly-diagnosed high-grade malignant glioma as an adjunct to surgery and radiation. Recurrent glioblastoma multiforme as an adjunct to surgery.
Adult Dosage:
See literature. Place 8 wafers (61.6mg) in the resection cavity if the size and shape of it allows; max 8 wafers per surgical procedure.
Children Dosage:
Not recommended.
GLIADEL Warnings/Precautions:
Avoid communication between surgical resection cavity and ventricular system to prevent wafer from migrating and causing obstructive hydrocephalus. If communication larger than diameter of wafer exists, it should be closed prior to wafer implantation. Pregnancy (Cat.D). Nursing mothers: not recommended.
GLIADEL Classification:
Nitrosurea.
Adverse Reactions:
Abdominal pain, back pain, chest pain, intracranial hypertension, abnormal healing, brain edema, meningitis or abscess; intracerebral mass effect.
How Supplied:
Single-dose treatment box (8 wafers)—1
