Indications for GVOKE:
Adults and Children:
<2yrs: not established. Give by SC inj into lower abdomen, outer thigh, or outer upper arm. May repeat after 15mins if no response. 2–<12yrs (<45kg): 0.5mg; (≥45kg): 1mg. ≥12yrs: 1mg.
Previously undiagnosed pheochromocytoma. Conditions with insufficient hepatic glycogen (eg, starvation, adrenal insufficiency, chronic hypoglycemia); treat with glucose. Necrolytic migratory erythema (due to continuous infusion). Glucagonoma: if suspected, test prior to initiation and monitor during therapy. Pregnancy. Nursing mothers.
May cause transient increase in BP and pulse with β-blockers. Antagonized by indomethacin. May potentiate warfarin.
Adults: nausea, vomiting, inj site edema raised ≥1mm, headache; children: nausea, hypoglycemia, vomiting, headache, abdominal pain, hyperglycemia, inj site discomfort and reaction, urticaria; allergic reactions.
Generic Drug Availability:
Prefilled syringes (PFS)—1, 2; HypoPen autoinjectors—2