Hyperlipoproteinemias:

Indications for: LEQVIO

Adjunct to diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD), who require additional lowering of LDL-C.

Limitations of Use:

The effect on cardiovascular morbidity and mortality has not been determined.

Adult Dosage:

Give by SC inj into abdomen, thigh, or upper arm. Initially 284mg as a single inj, repeat at 3 months, and then every 6 months. Measure LDL-lowering effect as early as 30 days after initiation and anytime thereafter.

Children Dosage:

Not established.

LEQVIO Warnings/Precautions:

Do not inject into areas of active skin disease or injury (eg, sunburns, skin rashes, inflammation, skin infections). ESRD. Severe hepatic impairment. Pregnancy: avoid. Nursing mothers.

LEQVIO Classification:

Small interfering RNA (siRNA).

Adverse Reactions:

Inj site reaction, arthralgia, urinary tract infection, diarrhea, bronchitis, pain in extremity, dyspnea.

Generic Drug Availability:

NO

How Supplied:

Single-dose prefilled syringe—1

Pricing for LEQVIO

1.5ml of 284mg/1.5ml syringe (Qty: 1)
Appx. price $3212
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