Select therapeutic use:

Colorectal disorders:

Indications for LINZESS:

Irritable bowel syndrome with constipation (IBS-C).

Adult Dosage:

Swallow whole. Take on empty stomach, at least 30 mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. 290mcg once daily.

Children Dosage:

<6yrs: contraindicated. 6–<18yrs: avoid.

LINZESS Contraindications:

Children <6yrs old. Known or suspected mechanical GI obstruction.

Boxed Warning:

Risk of serious dehydration in pediatric patients.

LINZESS Warnings/Precautions:

Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.

LINZESS Classification:

Guanylate cyclase-C agonist.

Adverse Reactions:

Diarrhea, abdominal pain, flatulence, abdominal distention.

Metabolism:

GI.

Drug Elimination:

Fecal.

Generic Drug Availability:

NO

How Supplied:

Caps—30

Pricing for LINZESS

145mcg capsule (Qty: 30)
Appx. price $486
GoodRx

Constipation and bowel cleansers:

Indications for LINZESS:

Chronic idiopathic constipation (CIC).

Adult Dosage:

Swallow whole. Take on empty stomach, at least 30 mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. 145mcg once daily. A dosage of 72mcg once daily may be used based on individual presentation or tolerability.

Children Dosage:

<6yrs: contraindicated. 6–<18yrs: avoid.

LINZESS Contraindications:

Children <6yrs old. Known or suspected mechanical GI obstruction.

Boxed Warning:

Risk of serious dehydration in pediatric patients.

LINZESS Warnings/Precautions:

Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.

LINZESS Classification:

Guanylate cyclase-C agonist.

Adverse Reactions:

Diarrhea, abdominal pain, flatulence, abdominal distention.

Metabolism:

GI.

Drug Elimination:

Fecal.

Generic Drug Availability:

NO

How Supplied:

Caps—30

Pricing for LINZESS

145mcg capsule (Qty: 30)
Appx. price $486
GoodRx