Angina:
Indications for: Nicardipine
Chronic stable angina.
Adult Dosage:
Initially 20mg 3 times daily; adjust at intervals of at least 3 days; max 120mg daily. Severe hepatic impairment: initially 20mg twice daily. Renal insufficiency: 20mg 3 times daily and titrate carefully.
Children Dosage:
<18yrs: not recommended.
Nicardipine Contraindications:
Advanced aortic stenosis.
Nicardipine Warnings/Precautions:
Exacerbation of angina. Heart failure. Acute cerebral infarction or hemorrhage. Hepatic or renal impairment. Measure blood pressure 1–2hrs and 8hrs after dosing. Pregnancy (Cat.C). Nursing mothers: not recommended.
Nicardipine Classification:
Calcium channel blocker (CCB) (dihydropyridine).
Nicardipine Interactions:
Potentiated by cimetidine. Increases serum levels of cyclosporine, tacrolimus; monitor and adjust its dose. Possibly potentiates digoxin; monitor.
Adverse Reactions:
Increased angina, hypotension, flushing, headache, pedal edema, asthenia, dizziness, tachycardia, somnolence, GI upset, insomnia.
Note:
Formerly known under the brand name Cardene.
How Supplied:
Contact supplier.
Hypertension:
Indications for: Nicardipine
Hypertension.
Adult Dosage:
Initially 20mg 3 times daily; adjust at intervals of at least 3 days; max 120mg daily. Severe hepatic impairment: initially 20mg twice daily.
Children Dosage:
<18yrs: not recommended.
Nicardipine Contraindications:
Advanced aortic stenosis.
Nicardipine Warnings/Precautions:
Angina. Heart failure. Acute cerebral infarction or hemorrhage. Hepatic or renal impairment. Pheochromocytoma. For caps: measure blood pressure (BP) 1–2 hrs and 8 hrs after dosing. For IV: monitor BP before and during infusion; avoid rapid or excessive reductions, intra-arterial administration or extravasation; switch to oral form when possible. Pregnancy (Cat.C). Nursing mothers: not recommended.
See Also:
Nicardipine Classification:
Calcium channel blocker (CCB) (dihydropyridine).
Nicardipine Interactions:
Potentiated by cimetidine. Increases serum levels of cyclosporine, tacrolimus; monitor and adjust its dose. Possibly potentiates digoxin; monitor.
Adverse Reactions:
Increased angina, flushing (caps), headache, pedal edema, asthenia, dizziness, somnolence (caps), tachycardia, GI upset, sweating; ECG abnormalities, orthostatic hypotension, ventricular extrasystoles, local reactions (inj).
Note:
Formerly known under the brand name Cardene.
How Supplied:
Caps 20mg, 30mg—contact supplier; IV (10mL amps)—10; Premixed—200mL
