Indications for: Selegiline

Adjunct to levodopa/carbidopa in Parkinsonism.

Adult Dosage:

5mg at breakfast and at lunch; max 10mg/day. After 2–3 days, levodopa/carbidopa dosage may be reduced by 10–30%; further reductions may be possible later.

Children Dosage:

Not established.

Selegiline Contraindications:

Concomitant meperidine, possibly other opioids.

Selegiline Warnings/Precautions:

Selectivity for MAO type B diminishes at doses over 10mg/day. Pregnancy (Cat.C). Nursing mothers: not recommended.

Selegiline Classification:

MAO-B inhibitor.

Selegiline Interactions:

See Contraindications. Avoid concomitant tricyclic antidepressants or selective serotonin reuptake inhibitors (SSRIs). Allow at least 5 weeks (or more if used chronically or at high doses) between fluoxetine discontinuance and 2 weeks between paroxetine or sertraline discontinuance before starting selegiline; allow 2 weeks between selegiline discontinuance before starting tricyclic antidepressants or SSRIs. Caution with tyramine-containing foods and with sympathomimetics.

Adverse Reactions:

Nausea, dizziness, lightheadedness, syncope, abdominal pain, confusion, vivid dreams, hallucinations, dry mouth, headache.


Formerly known under the brand name Eldepryl.

How Supplied:

Contact supplier