Parkinsonism:
Indications for Selegiline:
Adjunct to levodopa/carbidopa in Parkinsonism.
Adult:
5mg at breakfast and at lunch; max 10mg/day. After 2–3 days, levodopa/carbidopa dosage may be reduced by 10–30%; further reductions may be possible later.
Children:
Not established.
Contraindications:
Concomitant meperidine, possibly other opioids.
Warnings/Precautions:
Selectivity for MAO type B diminishes at doses over 10mg/day. Pregnancy (Cat.C). Nursing mothers: not recommended.
Pharmacologic Class:
MAO-B inhibitor.
Interactions:
See Contraindications. Avoid concomitant tricyclic antidepressants or selective serotonin reuptake inhibitors (SSRIs). Allow at least 5 weeks (or more if used chronically or at high doses) between fluoxetine discontinuance and 2 weeks between paroxetine or sertraline discontinuance before starting selegiline; allow 2 weeks between selegiline discontinuance before starting tricyclic antidepressants or SSRIs. Caution with tyramine-containing foods and with sympathomimetics.
Adverse Reactions:
Nausea, dizziness, lightheadedness, syncope, abdominal pain, confusion, vivid dreams, hallucinations, dry mouth, headache.
Note:
Formerly known under the brand name Eldepryl.
How Supplied:
Contact supplier
