Bacterial infections:

Indications for SIVEXTRO INJECTION:

Susceptible acute bacterial skin and skin structure infections (ABSSSI).

Adults and Children:

<12yrs: not established. Give by IV over 1 hour. ≥12yrs: 200mg once daily for 6 days. Switching from IV to oral: no dose adjustment necessary.

Warnings/Precautions:

Not adequately evaluated in patients with neutropenia (ANC <1000 cells/mm3); consider alternate therapies. Risk of C. difficile-associated diarrhea; discontinue if suspected or confirmed. Pregnancy. Nursing mothers.

See Also:

Pharmacologic Class:

Oxazolidinone.

Interactions:

Tabs: May potentiate oral BCRP substrates; consider interrupting co-administered substrates esp. those with narrow therapeutic index (eg, methotrexate, topotecan); monitor if coadministration (including rosuvastatin) is necessary.

Adverse Reactions:

Nausea, headache, diarrhea, infusion- or inj site reactions, vomiting, dizziness. In children: phlebitis, increased hepatic transaminases.

Generic Availability:

NO

How Supplied:

Tabs—6 (blister pack), 30; single-dose vials—10