Indications for: UROCIT-K
Renal tubular acidosis with calcium stones. Hypocitraturic calcium oxalate nephrolithiasis. Uric acid lithiasis.
Take within 30mins of meals or bedtime snack. Adjust based on urinary citrate levels and/or pH. Urinary citrate <150mg/day: 30mEq twice daily or 20mEq 3 times daily. Urinary citrate >150mEq/day: 15mEq twice daily or 10mEq 3 times daily. Max 100mEq/day.
See full labeling. Hyperkalemia or predisposing conditions. Delayed gastric emptying, esophageal compression, intestinal obstruction or stricture. Peptic ulcer disease. UTI. Renal insufficiency (GFR <0.7mL/kg/min).
Restrict salt intake and encourage high fluid intake. Discontinue if severe vomiting, GI pain or bleeding occurs and follow-up. Monitor 24 hour urinary citrate, urinary pH, serum electrolytes, CBC, ECG, at least every 4 months; discontinue if hyperkalemia, significant rise in serum creatinine, or significant fall in hematocrit or hemoglobin occurs. Pregnancy. Nursing mothers.
Avoid concomitant potassium-sparing diuretics, anticholinergics, other drugs that slow GI motility. Monitor digoxin. May interfere with some urinary tract antibiotics. Concomitant NSAIDs, RAAS inhibitors (eg, ACEIs, ARBs, spironolactone, eplerenone, aliskiren): closely monitor potassium levels.
Hyperkalemia, GI upset, irritation, bleeding.
Generic Drug Availability: