Endocrinology News Archive

Late-Onset Epilepsy Linked to APOE ε4, Smoking, Diabetes

The risk for late-onset epilepsy was lower in patients with higher physical activity levels and moderate alcohol intake.

Better Glycemic Control With Closed-Loop Insulin Delivery

Day-and-night hybrid closed-loop insulin delivery improves glucose control compared with sensor-augmented pump therapy.

Diabetes Common in Patients With Ischemic, Hemorrhagic Stroke

Approximately 28% of stroke patients have diabetes, and the presence of diabetes can increase the risk for poor stroke outcome.

Ketogenic Diet May Benefit Ovarian, Endometrial Cancer Patients

Women with ovarian or endometrial cancer who adhere to a ketogenic diet may benefit from a selective loss of fat mass and a reduction in fasting serum insulin, while still retaining lean mass.

Disorders in Pregnancy May Increase Risk for Hot Flashes During Menopause

Hypertensive disorders of pregnancy and gestational diabetes may increase the risk for hot flashes during menopause.

Light Therapy Offers Nonpharmacologic Treatment for Perimenopausal Depression

Light treatments successfully corrected abnormal timing of melatonin circadian rhythms in perimenopausal women with depression and improved mood and sleep within 2 weeks.

Risk for Hypercalciuria With Recommended Dose of Vitamin D Supplement

The upper level of vitamin D recommended by the Endocrine Society can result in frequent hypercalciuria.

CPAP for OSA Does Not Improve Diabetic Macular Edema or Visual Acuity

Continuous positive airway pressure for obstructive sleep apnea in patients with type 2 diabetes offered no improvement in visual acuity compared with usual care alone.

Combination Immunosuppressive Therapy Beneficial for Type B Insulin Resistance

A combined immunosuppressive regimen was found to be a highly effective and safe treatment for patients with type B insulin resistance.

Lorcaserin Facilitates Weight Loss in Overweight, Obese

Increased weight loss vs placebo with no rise in rate of extended major cardiovascular events.

Participation Up With Online Diabetes Prevention Program

But weight loss no different for online, in-person DPP for obese/overweight veterans with prediabetes.

Total Diabetes at 14% in US Adults for 2013-2016

Prevalence of diagnosed and undiagnosed diabetes 9.7 and 4.3%; prevalence increased with age.

Lower Hypoglycemia Risk, Greater Weight Loss With SGLT2 Inhibitor, Sulfonylurea in T2D

SGLT-2i exhibited superior effects in terms of weight loss and did not increase the risk for hypoglycemia in dual therapy with sulfonylurea.

Lifestyle Interventions Cut Excess Gestational Weight Gain

Findings among diverse population of overweight, obese women.

Physical Activity as a Lifestyle Factor Influencing Early Menopause

Researchers concluded that physical activity was not associated with risk for early menopause.

Poor Glycemic Control Associated With Higher Risk for Dementia in Older Adults With T1D

Repeated exposure to high levels of HbA1c was associated with increased risk for dementia in a cohort of patients age ≥50 with type 1 diabetes.

Intensive Blood Pressure Therapy Lowers Cardiovascular Risk in Diabetes

Intensive blood pressure therapy is associated with a significantly lower risk for serious cardiovascular events in the adults with diabetes.

Higher Aldosterone Levels Tied to Incident Type 2 Diabetes Risk

Racial/ethnic differences seen in the association of aldosterone with incident type 2 diabetes.

Behavioral Weight Loss Interventions May Prevent Obesity

The USPSTF recommends that clinicians refer adults with a body mass index of 30 or higher to intensive, multicompetent behavioral interventions.

Imvexxy Now Available in 4mcg Dosage Strength for Dyspareunia Due to Menopause

According to the Imvexxy prescribing information, women should generally be started at the 4mcg dosage strength with dosage adjustment guided by clinical response.

Guidelines for Managing Perimenopausal Depression Now Available

The 5 topics addressed by the 11-member expert panel include epidemiology, clinical presentation, therapeutic effects of antidepressants, effects of hormone therapy, and the effectiveness of other therapies (eg, psychotherapy, exercise, natural health products).

T1D, Poor Glycemic Control Linked to Infection Development

Researchers found that patients with T1DM and poor glycemic control were more frequently diagnosed with infections.

Excess Cardiac Risk Varies With Age of Onset of T1D

Excess risk differed by up to 5 times across different diagnosis age groups.

Assessing the Evidence of Aspirin for Primary Prevention in Diabetes

The substantial burden of cardiovascular disease in patients with diabetes has led to the exploration of various cardiovascular disease prevention strategies, including the use of aspirin.

Dexamethasone Improves Outcomes for Patients Undergoing In Vitro Fertilization

Investigators assessed whether adrenal suppression with low-dose dexamethasone improved IVF outcomes.

PedsQL 3.2 Diabetes Modules Display Excellent Measurement Ability

The PedsQL 3.2 can assist in identify new and existing therapeutic interventions for individuals with different diabetes-specific health-related quality of life profiles.

Updated Consensus on Management of Acromegaly Includes New Recommendations

Experts in the management of acromegaly provide new recommendations on the medical management of acromegaly since the last published update in 2014.

Skin Microbiota Differ for Obese, Non-Obese Undergoing C-Section

Obese women have significantly higher bacterial biomass of lower diversity at the incision site.

Risk of Thyroid Dysfunction Not Associated With HIV Status

Compared with uninfected individuals, people with HIV controlled with combination antiretroviral therapy are not at increased risk of developing thyroid dysfunction.

Medicaid Expansion Linked to Increase in Diabetes Prescription Fills

Fills for insulin and newer medications increased by 40 and 39%, respectively.

Breastfeeding Linked to Lower Risk of Stroke Post-Menopause

Stroke risk 19% lower with breastfeeding for 1 to 6 months; stronger link for longer duration.

High Prevalence of Diabetes in Those With Severe Mental Illness

Prevalences of diabetes and prediabetes higher among racial/ethnic minorities with mental illness.

Genitourinary Syndrome of Menopause: A Consensus Statement From the ISSWSH

The International Society for the Study of Women's Sexual Health convened an expert consensus panel to discuss the use of androgens in the management of genitourinary syndrome of menopause.

Treating Painful Diabetic Peripheral Neuropathy With Electroacupuncture

Investigators sought to determine the safety and efficacy of electroacupuncture for painful diabetic peripheral neuropathy.

Two Strategies for Preventing Diabetes in Minority Patients

Physicians can stress the factors in a patient's control and change messaging about the condition.

FDA to Review Gimoti for Diabetic Gastroparesis in Adult Women

The FDA has set a Prescription Drug User Fee Act target date of April 1, 2019.

Characteristics of Menstrual Cycle Associated With Early Natural Menopause

Investigators examined the relationship between menstrual cycle characteristics in adolescence and early adulthood and the risk for early natural menopause.

Two-Screen Program More Effective for Identifying Congenital Hypothyroidism

There are 14 states that perform a routine second screening in infants at approximately 2 weeks of age.

AHA: A Diverse Diet May Not Promote a Healthy Weight

American Heart Association science advisory recommends healthy eating patterns instead.

No Impact on Carotid Artery Intima-Media Thickness Following Cessation of Menopausal Hormone Therapy

A follow-up study from KEEPS found that cessation of menopausal hormone therapy did not change the expected trajectory of carotid artery intima-media thickness over a 3-year period.

ADA Releases Updated Guidelines for Managing Pediatric Type 1 Diabetes

It is critical for us to remember that children are not little adults. Pediatric-onset diabetes is different from adult-onset diabetes due to its distinct epidemiology, pathophysiology, developmental considerations, and response to therapy.

American Heart Association Urges Screen Time Limits for Youth

Increasing screen trends may have negative cardiometabolic impact; panel calls for more research.

Ectopic Lipid Deposition and Insulin Resistance Higher in Postmenopausal Women

The insulin sensitivity in post- and premenopausal women along with lipid deposition in the liver and skeletal muscle was examined.

Low-Carb Diet May Reduce HbA1c More Than Low-Fat Diet in T2D

Investigators compared low-carbohydrate with low-fat diet on glucose control and other metabolic and anthropometric variables in T2D.

Hepatic Markers Linked to Early Predictors of Type 2 Diabetes Risk in Women

Circulating hepatic markers may predict the risk for diabetes in women.

FDA Approves FreeStyle Libre 14 Day Flash Glucose Monitoring System

The new Flash Glucose Monitoring System enables patients to wear the sensor for up to 14 days compared with the existing FreeStyle Libre System that was approved for 10-day wear.

Independent Relationship Between CV Mortality, Oxidative DNA Damage in Type 2 Diabetes

This represents the prospective study confirming an independent relationship between cardiovascular mortality and oxidative DNA damage in type 2 diabetes.

WIC Program Enrollment Linked to Declining Pediatric Obesity

Childhood obesity continues to be a public health issue that requires improved policies and interventions at both the individual and population level.

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.

Basal Insulin Analogs vs NPH Insulin to Reduce Hypoglycemia-Linked ED Visits in T2D

Compared with human neutral protamine Hagedorn insulin, basal insulin analogs do not reduce risk of hypoglycemia-linked ED visits or hospital admissions in T2D.

Diabetes Diagnosis May Impact Health Behaviors of Family

Small changes in health behaviors seen for partners of those newly diagnosed with diabetes.

NP, PA Treatment Comparable for Patients With CVD or Diabetes

Effectiveness of care and healthcare resource use for diabetes or cardiovascular disease were comparable among patients receiving care from an NP vs those managed by a PA.

Link Between Bullous Pemphigoid and Dipeptidyl Peptidase-4 Inhibitors

The relationship between bullous pemphigoid and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.

Higher Visceral Fat Ratio Seen With Recurring Urolithiasis

No differences seen with other fat volume measures between recurring, first-time stones.

Menopause Transition Often Prompts Changes in Migraine Pattern, Characteristics

This retrospective study sought to assess migraine patterns in 69 menopausal women between ages 40 and 60 who were treated at Partners Healthcare Hospitals for concurrent migraine headache.

Reproductive Dysfunction Risk in Women Taking Long-Term Opioids for Musculoskeletal Pain

Women prescribed long- vs short-term opioids for chronic musculoskeletal pain may be at increased risk for menopause and abnormal menstruation.

Continuous Subcutaneous Insulin Infusion May Reduce Basal Hyperglycemia in T2D

Patients with type 2 diabetes who were initially treated with multiple daily injections were assessed before and after switching to continuous subcutaneous insulin infusion.

1996 to 2013 Saw Large Increase in Diabetes Spending

Increased spending per encounter has been the biggest driver of overall rise in spending.

AMA Adopts Policy to Cut Sugar Sweetened Drink Consumption

Policy supports evidence-based strategies such as excise taxes, adding warning labels

Diabetes Risk Associated With Cirrhosis, Not Chronic HCV Infection, in HIV Positive Patients

Cirrhosis is associated with an increased risk for diabetes mellitus among patients living with HIV.

Weight Loss Linked to Reversal of Atrial Fibrillation Progression

Increased weight loss with risk factor management associated with greater atrial fibrillation freedom.

Empagliflozin Reduces Risk for Nephropathy Regardless of Blood Pressure, LDL Cholesterol, HbA1c

Investigators examined renal outcomes when controlling cardiovascular risk factors, such as blood pressure, LDL-C, and HbA1c.

Menopausal Hormone Therapy Slows Cognitive Decline in Postmenopausal Women

Hormone therapy in postmenopausal women with mild cognitive impairment was examined.

Risk for Below Knee Amputations With Canagliflozin vs Other Antihyperglycemic Agents

Investigators analyzed real world data to examine the risk for below-knee amputations in patients with type 2 diabetes taking canagliflozin vs other medications.

Beta-Blockers Show Varied Effects on Hypoglycemic Mortality Risk in Diabetes

Investigators examined the relationship between the use of β-blockers and incidence of hypoglycemia and risk for mortality in hospitalized patients with diabetes.

Pen vs Patch Bolus Insulin Delivery for T2D Using CGM

Investigators compared 2 methods of delivering bolus insulin, pen vs patch, using metrics from continuous glucose monitoring.

Metabolic Health Predicative of Cognitive Development in Children

Researchers assessed whether current metabolic parameters are inversely associated with cognitive functioning.

Liraglutide May Prevent Dementia in Elderly With Type 2 Diabetes

Investigators examined the efficacy of liraglutide for the prevention of dementia in elderly patients with type 2 diabetes.

Age, Baseline HbA1c May Predict Glycemic Control in Newly Diagnosed Type 2 Diabetes

Investigators examined the effectiveness of oral agents vs insulin as an initial treatment option for people newly diagnosed with type 2 diabetes.

Elevated Triglycerides, Diabetes May Be Predictors of Major Cardiovascular Events

Investigators examined cardiovascular outcomes in patients with elevated triglyceridemia and diabetes treated with statins.

Safety and Performance of Omnipod HCL for Children With Type 1 Diabetes

In children with type 1 diabetes, the Omnipod hybrid closed-loop personal model system was safe and performed well.

Type 2 Diabetes Does Not Affect Pneumonia Incidence, Outcomes After Stroke

Investigators examined the incidence and outcomes of pneumonia in patients with acute ischemic stroke and type 2 diabetes.

ITCA 650 Shows Efficacy in Reducing Weight, HbA1c in Type 2 Diabetes

The ITCA 650, a small titanium osmotic mini-pump, provides a subcutaneous infusion of exenatide over 3 or 6 months.

MEDI0382 Safe, Effective for Normalizing Glucose, Weight Loss in Type 2 Diabetes

MEDI0382 reduced body weight and normalized fasting and postprandial blood glucose levels in patients with type 2 diabetes.

Chronic Kidney Disease More Common in Type 2 Diabetes Than in Type 1 Diabetes

Investigators examined the prevalence of chronic kidney disease in adults with type 1 diabetes compared with type 2 diabetes.

Implantable Continuous Glucose Monitoring Device Safe, Effective for Adolescents

The safety assessment included incidence of insertion or procedure-related removal and device-related serious adverse events through 180 after insertion.

USPSTF Favors Osteoporosis Screening to Prevent Fracture

Screening with bone measurement recommended for women aged 65, younger women at risk

Osteoporosis Fracture Risk Awareness Lacking in Postmenopausal Women

Postmenopausal women have little awareness of osteoporotic fracture risk and poor understanding that a fragility fracture may be indicative of osteoporosis and that it increases future fracture risk.

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

Systemic shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis.

Cleared Blood Glucose Monitor Systems Not Always Accurate

Six of 18 systems met predetermined accuracy standard in three of three studies

Sodium Chloride Fluid Infusion Rates Do Not Affect Pediatric Diabetic Ketoacidosis

Sodium chloride content of intravenous fluids does not affect neurologic events in children with diabetic ketoacidosis.

Maternal Glucose, Fetal Genotype Independently Affect Birth Weight

Fetal genetic score for birth weight affects fetal growth at various maternal fasting plasma glucose levels.

No Additional Benefits With Vaginal Estradiol Tablets, Moisturizers for Postmenopausal Vulvovaginal Symptoms

Prescribed vaginal estradiol tablets and over-the-counter vaginal moisturizers may not be more effective than placebos for postmenopausal vulvovaginal symptoms.

Long-Term Type 1 Diabetes Associated With Cognitive Decline

Deficits similar for long-term type 1 diabetes and age-matched patients with type 2 diabetes

Cancer Development Linked to Increased Diabetes Risk

Increased risk of subsequent diabetes independent of traditional diabetes risk factors

Childhood Obesity/Overweight Steadily Increased From 1999 to 2014

If trends continue, about one-third of children and one-half of teens will be obese/overweight by 2030.

Nutraceuticals Containing Equol May Be Effective for Postmenopausal Symptoms

Equol-containing nutraceuticals may be beneficial for postmenopausal women with vaginal symptoms.

More Rapid Decline in Kidney Function for Diagnosed Diabetes

Much steeper decline in adjusted mean eGFR for those with diagnosed diabetes versus those without

Imvexxy Approved for Moderate to Severe Dyspareunia Due to Menopause

The FDA approval was supported by findings from a Phase 3, randomized, double-blind, placebo-controlled study that evaluated Imvexxy (4mcg and 10mcg) vs placebo from baseline to week 12.

Male Thyroid Cancer Survivors Face Higher CVD Risk

Age at diagnosis, sex, BMI, and thyroid-stimulating hormone suppression therapy affect CVD risk

Improving Insulin Access: ADA Public Policy Recommendations

The American Diabetes Association (ADA) has released a public policy statement that outlines long- and short-term recommendations for improving insulin affordability.

AAPA Launches Primary Care Obesity Management Certificate Program

The new program, announced by AAPA, will allow its participants to obtain 30 CME credits and an OMA-issued Certificate of Primary-Care Obesity Management after completion.

Obesity Treatment Education, Training Needed in PA Programs

Recognizing the obesity epidemic and educating physician assistants on the implications of this condition and how they should be caring for obese patients should be prioritized, according to the study authors.

US Nursing Home Costs Due to Diabetes Vary Greatly by State

Per-person diabetes-attributable costs ranged from 374 in New Mexico to 1,610 in Washington, D.C.

Prevalence of Obese, Allergic Asthma Phenotypes Examined in US Children

The study authors examined data obtained from the 2007-2008 National Survey of Children's Health (NSCH) to determine the prevalence, risk factors, as well as the severity of asthma phenotypes.

Artificial Pancreas Systems Safe, Effective in Type 1 Diabetes

Artificial pancreas treatments are safe and effective for managing type 1 diabetes.

Diabetes and Mortality: Comparing SGLT-2 Inhibitors, GLP-1 Agonists, and DPP-4 Inhibitors

For patients with type 2 diabetes, sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 agonists significantly reduce mortality rates compared with dipeptidyl peptidase 4 inhibitors.

Diabetes Prevalence by Type in the United States: CDC report

The CDC conducted a study to estimate the prevalence of diagnosed diabetes among adults in 2016 by primary type.

FDA Approves AI Device to Detect Diabetic Retinopathy

Artificial intelligence software that can detect diabetic retinopathy has been approved by the U.S. Food and Drug Administration.

Eating Pecans May Cut Risk of Cardiovascular Disease, Diabetes

Benefits seen in markers of cardiometabolic disease, including insulin sensitivity

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