Endocrinology News Archive

Use of Diabetes Monitoring Tests in Primary Care Suboptimal

Less than 60% of patients with diabetes given HbA1c, lipid profile tests in preceding 12 months.

Topical Methyl Estradiolpropanoate Safe, Effective for Treating Estrogen-Deficient Skin

A study was conducted to assess the safety, tolerability, and efficacy of methyl estradiolpropanoate, a topical soft estrogen cosmeceutical for the treatment of estrogen-deficient skin.

Reducing Systolic Blood Pressure With Liraglutide: Predictors and Correlates

Patients with type 2 diabetes treated with liraglutide experience a greater reduction in systolic BP if they have lower baseline continuous glucose monitoring values and higher diastolic BP.

CDC: Weight, Waist Size, BMI Increased for Many US Adults

1999-2000 to 2015-2016 saw increase in mean weight, waist circumference, BMI for many subgroups.

ADA's 2019 Standards of Medical Care in Diabetes Focus on Patient-Centered Care

The ADA published its 2019 Standards of Medical Care in Diabetes, an evidence-based document intended to provide clinicians, patients, and other stakeholders in the diabetes treatment landscape with up-to-date recommendations.

Cesarean Delivery Outcomes May Influence Risk for Early Childhood Overweight

Elective cesarean delivery may influence the risk of early childhood overweight.

Endocrine Treatment Does Not Impair Neuropsychological Performance

Findings observed in early-stage breast cancer survivors followed for up to 6 years after treatment.

Clinical Indicators of Risk for Addison Disease in Patients With T1D

Treatment of thyroid disease, severe infections, glucagon prescriptions, and diabetic retinopathy occur more frequently in individuals with type 1 diabetes who are subsequently diagnosed with Addison disease.

Low-Risk Patients With T2D May Be Self-Testing Blood Glucose Too Often

Patients with stable type 2 diabetes may be unnecessarily self-monitoring blood glucose levels despite this practice being recognized as a low-value service.

Prevalence of Metabolically Healthy Adults in US Very Low

Fewer than a third of normal-weight adults, 8% of overweight adults are metabolically healthy.

Negative Attitudes Reported Toward Weight-Loss Surgery

Women more likely to think surgery is needed for health, less likely to consider it 'easy way out'.

Postmenopausal Women With Normal BMI May Still Be at Increased Risk for Breast Cancer

Postmenopausal women with normal BMI and elevated body fat levels are at increased risk of breast cancer.

Food Deprivation During Fetal Development Linked to Early Menopause, Premature Ovarian Failure

Women born during the Chinese famine period may be at increased risk for early natural menopause and premature ovarian failure.

Menopausal Hormone Therapy May Reduce Carpal Tunnel Syndrome Risk

To investigate the association between hormone therapy and carpal tunnel syndrome risk, researchers conducted a secondary analysis of the Women's Health Initiative (WHI) hormone therapy trials.

Sleep Quality in Women With Surgical vs Natural Menopause

Women who undergo surgical menopause have significantly worse sleep quality than those who experience natural menopause.

Measures of Maximum BMI, Weight History Linked to All-Cause Mortality

Gauging weight history in clinical practice may help identify patients at risk for weight-related mortality.

Skin Autofluorescence Predicts T2DM, Heart Disease, Mortality

Prediction independent of traditional risk factors such as MetS, glucose, HbA1c in general population.

History of Partner Violence Tied to Menopause Symptoms

History of sexual assault and current PTSD also associated with higher risk for menopause symptoms.

Comparative Assessment of Diabetes Outcomes With Physician, NP, PA Providers

Could type of clinician rendering care influence outcomes for patients with diabetes?

Mediterranean Diet, Physical Activity Effective for Weight Loss, Decreased Cardiovascular Events

A 12-month intensive lifestyle intervention including an energy-restricted Mediterranean diet, increased physical activity, and behavioral support for overweight/obese patients was found to be beneficial in decreasing adiposity and cardiovascular events.

ACC Releases Consensus Decision Pathway for CVD Risk Reduction in T2D and ASCVD

The American College of Cardiology published an expert consensus statement regarding decision considerations for novel cardiovascular risk reduction therapies in patients with type 2 diabetes and atherosclerotic cardiovascular disease.

Several Risk Factors More Strongly Linked to MI in Women

Blood pressure, smoking, type 1 and 2 diabetes linked to higher hazard ratios for women than men.

Severe Symptoms of Vulvovaginal Atrophy Associated With Reduced Quality of Life

Severity of symptoms of vulvovaginal atrophy in postmenopausal women was found to have an impact on quality of life.

Peer Support Reduces Hospitalizations in People With Diabetes and Depression

Patients with diabetes and depressive symptoms who received community-based peer support for diabetes management reported less frequent acute care visits and hospitalizations than patients with diabetes without depressive symptoms.

Parental Chronic Spinal Pain May Affect Prognosis in Adult Offspring

Individuals with chronic spinal pain, particularly those who are overweight or obese, may be less likely to recover from this condition if both their parents also have chronic spinal pain.

Food Assistance May Help Older Adults Adhere to Diabetes Medications

Food assistance may cut number of older adults with diabetes forgoing medications due to cost.

Healthy Diet Associated With Reduced Menopausal Symptoms

A diet high in fruits, vegetables, nuts, and legumes was found to be associated with a lower risk for physical, mental, and genitourinary symptoms of menopause compared with a diet high in fats, meats, desserts, and salts.

Lifestyle Intervention Program Reduces Diabetes, Metabolic Syndrome Risk

A 12-month interdisciplinary lifestyle intervention program for prediabetic and obese patients was found to significantly reduce the risk for development of diabetes and metabolic syndrome.

Early Menopause Associated With Shorter Life Expectancy, Early Diagnosis of Type 2 Diabetes

Early age of menopause development is associated with lower overall life expectancy and fewer years of life without diabetes.

Functional Disability Progression More Rapid in Postmenopausal Women With RA

Functional disability progressed more rapidly in postmenopausal compared with premenopausal women with rheumatoid arthritis.

Obesity as a Teen Ups Risk for Later Pancreatic Cancer

In men, overweight and even higher normal weight tied to increased risk.

Insurance Coverage for Adult Obesity Care Increasing

Findings among Medicaid, state employee health insurance programs in 2009 to 2017.

ADA Issues Position Statement on Comprehensive Care for Pediatric T2D

The American Diabetes Association issued a position statement outlining the recognition, management, and prevention of T2D in the pediatric population.

Guidelines for Physical Activity in America

The Physical Activity Guidelines for Americans provides recommendations for physical activity that have the potential to reduce the risk of obesity, type 2 diabetes, cardiovascular disease, dementia, and several cancers.

CDC: About 1 in 3 Adults With Prediabetes Has Arthritis

About 1 in 3 adults with prediabetes has arthritis, and half of those with both conditions are physically inactive and/or obese.

Tissue-Selective Estrogen Complex May Benefit Postmenopausal Women With Vaginal Bleeding, Breast Discomfort

Switching to tissue-selective estrogen complex from hormone therapy may benefit women with breast discomfort or vaginal bleeding.

Genetic Test Helps Identify Benign vs Malignant Thyroid Nodules

ThyroSeq v3 has 94% sensitivity, 82% specificity for Bethesda III and IV nodules.

Type 2 Diabetes May Have Adverse Effect on Parkinson Disease Symptoms, Outcomes

Patients with both Parkinson disease and type 2 diabetes were more likely to have cardiovascular comorbidities than those with only Parkinson disease.

Nonadherence, Discontinuation of Statins High in 1st Year of Prescription

Among older adults prescribed statins, diabetes, anxiety linked to nonadherence, discontinuation.

Poor Diet, Physical Activity Behaviors May Lead to Metabolic Syndrome in Depression

Investigators examine the association between depression and metabolic syndrome, factoring in diet and physical activity.

Exposure to Ready-to-Eat Food Outlets Associated With Risk for Type 2 Diabetes

Access to ready-to-eat outlets that sell food for instant consumption is associated with greater risk for type 2 diabetes.

CDC: Prevalence of Gestational Diabetes 6.0% in 2016

Based on data from 40 jurisdictions, increase from 5.2 to 5.6% in GDM from 2012 to 2016.

Plant-Based Diets Beneficial for Adults With Type 2 Diabetes

For adults with type 2 diabetes, plant-based diets can improve psychological health, quality of life, hemoglobin A1c levels.

ASN: Aggressive Control of BP, Lipids in T2DM May Up Kidney Risk

Intensive blood pressure control and fenofibrate use in patients with type 2 diabetes who are at high risk for cardiovascular disease may increase the risk for adverse kidney events.

Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk

Prescription of antibiotics and acid-suppressing medications in early childhood is associated with an increased risk for obesity.

Gastric Banding vs Metformin for Improved Insulin Sensitivity in Mild T2D

Gastric banding and metformin resulted in similar improvements in insulin sensitivity in moderately obese adults with impaired glucose tolerance or mild T2D over a 2-year period.

Biomarkers of Dairy Fat Consumption Inversely Associated With Type 2 Diabetes Risk

Researchers found that higher levels of fatty acid biomarkers 15:0, 17:0, and trans-16:1n7 were inversely associated with risk for T2D.

Bijuva Approved for Moderate to Severe Vasomotor Symptoms From Menopause

Approval from the Food and Drug Administration (FDA) was supported by the Phase 3 Replenish trial which evaluated the safety and efficacy of Bijuva in generally healthy, postmenopausal women with a uterus for the treatment of moderate to severe hot flashes.

Severity of Metabolic Syndrome Indicates Risk for T2D, CVD in Prediabetes Treatment

Researchers analyzed how improvements in metabolic syndrome may impact the risk of developing type 2 diabetes and cardiovascular disease in patients with prediabetes.

Atherosclerosis Progression Differs According to Timing of Estradiol Therapy After Menopause

Higher levels of estradiol were inversely associated with carotid artery intima-media thickness progression in the early postmenopausal cohort but positively associated with it in the late postmenopausal group.

Glucose Dysregulation Seen Years Before Diabetes Diagnosis

Fasting plasma glucose, BMI elevated 10 years before diagnosis of prediabetes, diabetes.

Asthma May Increase Obesity Risk Later in Childhood

Early-onset asthma and wheezing may contribute to an increased risk of developing obesity later in childhood.

Weight Loss May Reduce Breast Cancer Risk in Postmenopausal Women

Postmenopausal women with weight loss have a reduced risk for breast cancer.

Exercise After Overnight Fasting Stabilizes Glucose Levels in Type 1 Diabetes

The effect of high-intensity interval training with a bout of moderate-intensity continuous training on glucose levels was examined in T1D.

Vegan Diet Associated With Weight Loss and Reduced Insulin Resistance

Investigators examine the effect of a low-fat, plant-based diet on insulin resistance and body composition.

Hormone Therapy Not Beneficial in Subclinical Hypothyroidism

No benefit regarding quality of life or thyroid-related symptoms found for thyroid hormone therapy.

Empagliflozin Impact on Life Expectancy Examined in T2DM Patients With CVD

For this analysis, the authors used follow-up data from all 7020 patients included in the EMPA-REG OUTCOME trial to estimate the effect of empagliflozin on all-cause mortality vs placebo over the duration of a patient's lifetime.

Childhood Obesity Persists Into Adolescence

Greater weight gain in early childhood often carries over to overweight and obesity in adolescence.

ADA, EASD Issue New Recommendations for Type 2 Diabetes

Recommendations for the management of type 2 diabetes have been updated, according to a consensus report by the American Diabetes Association and the European Association for the Study of Diabetes.

Late-Onset Epilepsy Linked to APOE ε4, Smoking, Diabetes

The risk for late-onset epilepsy was lower in patients with higher physical activity levels and moderate alcohol intake.

Better Glycemic Control With Closed-Loop Insulin Delivery

Day-and-night hybrid closed-loop insulin delivery improves glucose control compared with sensor-augmented pump therapy.

Diabetes Common in Patients With Ischemic, Hemorrhagic Stroke

Approximately 28% of stroke patients have diabetes, and the presence of diabetes can increase the risk for poor stroke outcome.

Ketogenic Diet May Benefit Ovarian, Endometrial Cancer Patients

Women with ovarian or endometrial cancer who adhere to a ketogenic diet may benefit from a selective loss of fat mass and a reduction in fasting serum insulin, while still retaining lean mass.

Disorders in Pregnancy May Increase Risk for Hot Flashes During Menopause

Hypertensive disorders of pregnancy and gestational diabetes may increase the risk for hot flashes during menopause.

Light Therapy Offers Nonpharmacologic Treatment for Perimenopausal Depression

Light treatments successfully corrected abnormal timing of melatonin circadian rhythms in perimenopausal women with depression and improved mood and sleep within 2 weeks.

Risk for Hypercalciuria With Recommended Dose of Vitamin D Supplement

The upper level of vitamin D recommended by the Endocrine Society can result in frequent hypercalciuria.

Gestational Diabetes Associated With Increased Risk for Postpartum Depression

These findings suggest an increased risk for postpartum depressive symptoms in mothers with gestational diabetes, independent of depressive symptomatology during pregnancy.

CPAP for OSA Does Not Improve Diabetic Macular Edema or Visual Acuity

Continuous positive airway pressure for obstructive sleep apnea in patients with type 2 diabetes offered no improvement in visual acuity compared with usual care alone.

Combination Immunosuppressive Therapy Beneficial for Type B Insulin Resistance

A combined immunosuppressive regimen was found to be a highly effective and safe treatment for patients with type B insulin resistance.

Lorcaserin Facilitates Weight Loss in Overweight, Obese

Increased weight loss vs placebo with no rise in rate of extended major cardiovascular events.

Participation Up With Online Diabetes Prevention Program

But weight loss no different for online, in-person DPP for obese/overweight veterans with prediabetes.

Total Diabetes at 14% in US Adults for 2013-2016

Prevalence of diagnosed and undiagnosed diabetes 9.7 and 4.3%; prevalence increased with age.

Lower Hypoglycemia Risk, Greater Weight Loss With SGLT2 Inhibitor, Sulfonylurea in T2D

SGLT-2i exhibited superior effects in terms of weight loss and did not increase the risk for hypoglycemia in dual therapy with sulfonylurea.

Lifestyle Interventions Cut Excess Gestational Weight Gain

Findings among diverse population of overweight, obese women.

Physical Activity as a Lifestyle Factor Influencing Early Menopause

Researchers concluded that physical activity was not associated with risk for early menopause.

Poor Glycemic Control Associated With Higher Risk for Dementia in Older Adults With T1D

Repeated exposure to high levels of HbA1c was associated with increased risk for dementia in a cohort of patients age ≥50 with type 1 diabetes.

Gestational Diabetes Tied to Subsequent Glucose Disorders

Long-term effects seen in mothers, but offspring not significantly overweight, obese.

Intensive Blood Pressure Therapy Lowers Cardiovascular Risk in Diabetes

Intensive blood pressure therapy is associated with a significantly lower risk for serious cardiovascular events in the adults with diabetes.

Higher Aldosterone Levels Tied to Incident Type 2 Diabetes Risk

Racial/ethnic differences seen in the association of aldosterone with incident type 2 diabetes.

Behavioral Weight Loss Interventions May Prevent Obesity

The USPSTF recommends that clinicians refer adults with a body mass index of 30 or higher to intensive, multicompetent behavioral interventions.

Imvexxy Now Available in 4mcg Dosage Strength for Dyspareunia Due to Menopause

According to the Imvexxy prescribing information, women should generally be started at the 4mcg dosage strength with dosage adjustment guided by clinical response.

Guidelines for Managing Perimenopausal Depression Now Available

The 5 topics addressed by the 11-member expert panel include epidemiology, clinical presentation, therapeutic effects of antidepressants, effects of hormone therapy, and the effectiveness of other therapies (eg, psychotherapy, exercise, natural health products).

T1D, Poor Glycemic Control Linked to Infection Development

Researchers found that patients with T1DM and poor glycemic control were more frequently diagnosed with infections.

Excess Cardiac Risk Varies With Age of Onset of T1D

Excess risk differed by up to 5 times across different diagnosis age groups.

Assessing the Evidence of Aspirin for Primary Prevention in Diabetes

The substantial burden of cardiovascular disease in patients with diabetes has led to the exploration of various cardiovascular disease prevention strategies, including the use of aspirin.

Dexamethasone Improves Outcomes for Patients Undergoing In Vitro Fertilization

Investigators assessed whether adrenal suppression with low-dose dexamethasone improved IVF outcomes.

PedsQL 3.2 Diabetes Modules Display Excellent Measurement Ability

The PedsQL 3.2 can assist in identify new and existing therapeutic interventions for individuals with different diabetes-specific health-related quality of life profiles.

Updated Consensus on Management of Acromegaly Includes New Recommendations

Experts in the management of acromegaly provide new recommendations on the medical management of acromegaly since the last published update in 2014.

Skin Microbiota Differ for Obese, Non-Obese Undergoing C-Section

Obese women have significantly higher bacterial biomass of lower diversity at the incision site.

Risk of Thyroid Dysfunction Not Associated With HIV Status

Compared with uninfected individuals, people with HIV controlled with combination antiretroviral therapy are not at increased risk of developing thyroid dysfunction.

Medicaid Expansion Linked to Increase in Diabetes Prescription Fills

Fills for insulin and newer medications increased by 40 and 39%, respectively.

Breastfeeding Linked to Lower Risk of Stroke Post-Menopause

Stroke risk 19% lower with breastfeeding for 1 to 6 months; stronger link for longer duration.

High Prevalence of Diabetes in Those With Severe Mental Illness

Prevalences of diabetes and prediabetes higher among racial/ethnic minorities with mental illness.

Genitourinary Syndrome of Menopause: A Consensus Statement From the ISSWSH

The International Society for the Study of Women's Sexual Health convened an expert consensus panel to discuss the use of androgens in the management of genitourinary syndrome of menopause.

Treating Painful Diabetic Peripheral Neuropathy With Electroacupuncture

Investigators sought to determine the safety and efficacy of electroacupuncture for painful diabetic peripheral neuropathy.

Two Strategies for Preventing Diabetes in Minority Patients

Physicians can stress the factors in a patient's control and change messaging about the condition.

FDA to Review Gimoti for Diabetic Gastroparesis in Adult Women

The FDA has set a Prescription Drug User Fee Act target date of April 1, 2019.

Characteristics of Menstrual Cycle Associated With Early Natural Menopause

Investigators examined the relationship between menstrual cycle characteristics in adolescence and early adulthood and the risk for early natural menopause.

Two-Screen Program More Effective for Identifying Congenital Hypothyroidism

There are 14 states that perform a routine second screening in infants at approximately 2 weeks of age.

AHA: A Diverse Diet May Not Promote a Healthy Weight

American Heart Association science advisory recommends healthy eating patterns instead.

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