Endocrinology News Archive

American Heart Association Urges Screen Time Limits for Youth

Increasing screen trends may have negative cardiometabolic impact; panel calls for more research.

Ectopic Lipid Deposition and Insulin Resistance Higher in Postmenopausal Women

The insulin sensitivity in post- and premenopausal women along with lipid deposition in the liver and skeletal muscle was examined.

Low-Carb Diet May Reduce HbA1c More Than Low-Fat Diet in T2D

Investigators compared low-carbohydrate with low-fat diet on glucose control and other metabolic and anthropometric variables in T2D.

Hepatic Markers Linked to Early Predictors of Type 2 Diabetes Risk in Women

Circulating hepatic markers may predict the risk for diabetes in women.

FDA Approves FreeStyle Libre 14 Day Flash Glucose Monitoring System

The new Flash Glucose Monitoring System enables patients to wear the sensor for up to 14 days compared with the existing FreeStyle Libre System that was approved for 10-day wear.

Independent Relationship Between CV Mortality, Oxidative DNA Damage in Type 2 Diabetes

This represents the prospective study confirming an independent relationship between cardiovascular mortality and oxidative DNA damage in type 2 diabetes.

WIC Program Enrollment Linked to Declining Pediatric Obesity

Childhood obesity continues to be a public health issue that requires improved policies and interventions at both the individual and population level.

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.

Basal Insulin Analogs vs NPH Insulin to Reduce Hypoglycemia-Linked ED Visits in T2D

Compared with human neutral protamine Hagedorn insulin, basal insulin analogs do not reduce risk of hypoglycemia-linked ED visits or hospital admissions in T2D.

Diabetes Diagnosis May Impact Health Behaviors of Family

Small changes in health behaviors seen for partners of those newly diagnosed with diabetes.

NP, PA Treatment Comparable for Patients With CVD or Diabetes

Effectiveness of care and healthcare resource use for diabetes or cardiovascular disease were comparable among patients receiving care from an NP vs those managed by a PA.

Link Between Bullous Pemphigoid and Dipeptidyl Peptidase-4 Inhibitors

The relationship between bullous pemphigoid and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.

Higher Visceral Fat Ratio Seen With Recurring Urolithiasis

No differences seen with other fat volume measures between recurring, first-time stones.

Menopause Transition Often Prompts Changes in Migraine Pattern, Characteristics

This retrospective study sought to assess migraine patterns in 69 menopausal women between ages 40 and 60 who were treated at Partners Healthcare Hospitals for concurrent migraine headache.

Reproductive Dysfunction Risk in Women Taking Long-Term Opioids for Musculoskeletal Pain

Women prescribed long- vs short-term opioids for chronic musculoskeletal pain may be at increased risk for menopause and abnormal menstruation.

Continuous Subcutaneous Insulin Infusion May Reduce Basal Hyperglycemia in T2D

Patients with type 2 diabetes who were initially treated with multiple daily injections were assessed before and after switching to continuous subcutaneous insulin infusion.

1996 to 2013 Saw Large Increase in Diabetes Spending

Increased spending per encounter has been the biggest driver of overall rise in spending.

AMA Adopts Policy to Cut Sugar Sweetened Drink Consumption

Policy supports evidence-based strategies such as excise taxes, adding warning labels

Diabetes Risk Associated With Cirrhosis, Not Chronic HCV Infection, in HIV Positive Patients

Cirrhosis is associated with an increased risk for diabetes mellitus among patients living with HIV.

Weight Loss Linked to Reversal of Atrial Fibrillation Progression

Increased weight loss with risk factor management associated with greater atrial fibrillation freedom.

Empagliflozin Reduces Risk for Nephropathy Regardless of Blood Pressure, LDL Cholesterol, HbA1c

Investigators examined renal outcomes when controlling cardiovascular risk factors, such as blood pressure, LDL-C, and HbA1c.

Menopausal Hormone Therapy Slows Cognitive Decline in Postmenopausal Women

Hormone therapy in postmenopausal women with mild cognitive impairment was examined.

Risk for Below Knee Amputations With Canagliflozin vs Other Antihyperglycemic Agents

Investigators analyzed real world data to examine the risk for below-knee amputations in patients with type 2 diabetes taking canagliflozin vs other medications.

Beta-Blockers Show Varied Effects on Hypoglycemic Mortality Risk in Diabetes

Investigators examined the relationship between the use of β-blockers and incidence of hypoglycemia and risk for mortality in hospitalized patients with diabetes.

Pen vs Patch Bolus Insulin Delivery for T2D Using CGM

Investigators compared 2 methods of delivering bolus insulin, pen vs patch, using metrics from continuous glucose monitoring.

Metabolic Health Predicative of Cognitive Development in Children

Researchers assessed whether current metabolic parameters are inversely associated with cognitive functioning.

Liraglutide May Prevent Dementia in Elderly With Type 2 Diabetes

Investigators examined the efficacy of liraglutide for the prevention of dementia in elderly patients with type 2 diabetes.

Age, Baseline HbA1c May Predict Glycemic Control in Newly Diagnosed Type 2 Diabetes

Investigators examined the effectiveness of oral agents vs insulin as an initial treatment option for people newly diagnosed with type 2 diabetes.

Elevated Triglycerides, Diabetes May Be Predictors of Major Cardiovascular Events

Investigators examined cardiovascular outcomes in patients with elevated triglyceridemia and diabetes treated with statins.

Safety and Performance of Omnipod HCL for Children With Type 1 Diabetes

In children with type 1 diabetes, the Omnipod hybrid closed-loop personal model system was safe and performed well.

Type 2 Diabetes Does Not Affect Pneumonia Incidence, Outcomes After Stroke

Investigators examined the incidence and outcomes of pneumonia in patients with acute ischemic stroke and type 2 diabetes.

ITCA 650 Shows Efficacy in Reducing Weight, HbA1c in Type 2 Diabetes

The ITCA 650, a small titanium osmotic mini-pump, provides a subcutaneous infusion of exenatide over 3 or 6 months.

MEDI0382 Safe, Effective for Normalizing Glucose, Weight Loss in Type 2 Diabetes

MEDI0382 reduced body weight and normalized fasting and postprandial blood glucose levels in patients with type 2 diabetes.

Chronic Kidney Disease More Common in Type 2 Diabetes Than in Type 1 Diabetes

Investigators examined the prevalence of chronic kidney disease in adults with type 1 diabetes compared with type 2 diabetes.

Implantable Continuous Glucose Monitoring Device Safe, Effective for Adolescents

The safety assessment included incidence of insertion or procedure-related removal and device-related serious adverse events through 180 after insertion.

USPSTF Favors Osteoporosis Screening to Prevent Fracture

Screening with bone measurement recommended for women aged 65, younger women at risk

Osteoporosis Fracture Risk Awareness Lacking in Postmenopausal Women

Postmenopausal women have little awareness of osteoporotic fracture risk and poor understanding that a fragility fracture may be indicative of osteoporosis and that it increases future fracture risk.

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

Systemic shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis.

Cleared Blood Glucose Monitor Systems Not Always Accurate

Six of 18 systems met predetermined accuracy standard in three of three studies

Sodium Chloride Fluid Infusion Rates Do Not Affect Pediatric Diabetic Ketoacidosis

Sodium chloride content of intravenous fluids does not affect neurologic events in children with diabetic ketoacidosis.

Maternal Glucose, Fetal Genotype Independently Affect Birth Weight

Fetal genetic score for birth weight affects fetal growth at various maternal fasting plasma glucose levels.

No Additional Benefits With Vaginal Estradiol Tablets, Moisturizers for Postmenopausal Vulvovaginal Symptoms

Prescribed vaginal estradiol tablets and over-the-counter vaginal moisturizers may not be more effective than placebos for postmenopausal vulvovaginal symptoms.

Long-Term Type 1 Diabetes Associated With Cognitive Decline

Deficits similar for long-term type 1 diabetes and age-matched patients with type 2 diabetes

Cancer Development Linked to Increased Diabetes Risk

Increased risk of subsequent diabetes independent of traditional diabetes risk factors

Childhood Obesity/Overweight Steadily Increased From 1999 to 2014

If trends continue, about one-third of children and one-half of teens will be obese/overweight by 2030.

Nutraceuticals Containing Equol May Be Effective for Postmenopausal Symptoms

Equol-containing nutraceuticals may be beneficial for postmenopausal women with vaginal symptoms.

More Rapid Decline in Kidney Function for Diagnosed Diabetes

Much steeper decline in adjusted mean eGFR for those with diagnosed diabetes versus those without

Imvexxy Approved for Moderate to Severe Dyspareunia Due to Menopause

The FDA approval was supported by findings from a Phase 3, randomized, double-blind, placebo-controlled study that evaluated Imvexxy (4mcg and 10mcg) vs placebo from baseline to week 12.

Male Thyroid Cancer Survivors Face Higher CVD Risk

Age at diagnosis, sex, BMI, and thyroid-stimulating hormone suppression therapy affect CVD risk

Improving Insulin Access: ADA Public Policy Recommendations

The American Diabetes Association (ADA) has released a public policy statement that outlines long- and short-term recommendations for improving insulin affordability.

AAPA Launches Primary Care Obesity Management Certificate Program

The new program, announced by AAPA, will allow its participants to obtain 30 CME credits and an OMA-issued Certificate of Primary-Care Obesity Management after completion.

Obesity Treatment Education, Training Needed in PA Programs

Recognizing the obesity epidemic and educating physician assistants on the implications of this condition and how they should be caring for obese patients should be prioritized, according to the study authors.

US Nursing Home Costs Due to Diabetes Vary Greatly by State

Per-person diabetes-attributable costs ranged from 374 in New Mexico to 1,610 in Washington, D.C.

Prevalence of Obese, Allergic Asthma Phenotypes Examined in US Children

The study authors examined data obtained from the 2007-2008 National Survey of Children's Health (NSCH) to determine the prevalence, risk factors, as well as the severity of asthma phenotypes.

Artificial Pancreas Systems Safe, Effective in Type 1 Diabetes

Artificial pancreas treatments are safe and effective for managing type 1 diabetes.

Diabetes and Mortality: Comparing SGLT-2 Inhibitors, GLP-1 Agonists, and DPP-4 Inhibitors

For patients with type 2 diabetes, sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 agonists significantly reduce mortality rates compared with dipeptidyl peptidase 4 inhibitors.

Diabetes Prevalence by Type in the United States: CDC report

The CDC conducted a study to estimate the prevalence of diagnosed diabetes among adults in 2016 by primary type.

FDA Approves AI Device to Detect Diabetic Retinopathy

Artificial intelligence software that can detect diabetic retinopathy has been approved by the U.S. Food and Drug Administration.

Eating Pecans May Cut Risk of Cardiovascular Disease, Diabetes

Benefits seen in markers of cardiometabolic disease, including insulin sensitivity

Obesity Can Negatively Affect Liver in Children As Young As 8

Increased adiposity in childhood may negatively impact liver function in children as young as 8 years old.

Fatigue, muscle aches more common in women with HIV than men

The two most prevalent HIV symptoms, fatigue and muscle aches, are more common in women than men and can worsen with menopause.

BMI associated with hepatocellular carcinoma risk for patients with chronic hepatitis B virus

BMI is positively correlated with increased hepatocellular carcinoma in patients with chronic HBV, though the risk is greater in women.

Early Care Transitions Beneficial for Adolescents with Type 1 Diabetes

A diabetes transition registry may help adolescents with type 1 diabetes plan and prepare for independent adult care.

Better glycemic control, weight reduction with surgical treatment for youths with T2D, severe obesity

For adolescents with type 2 diabetes and severe obesity, surgical therapy facilitates glycemic control and weight reduction better than medical therapy.

New type 2 diabetes guideline recommends more moderate HbA1c target

The American College of Physicians has developed recommendation statements to guide clinicians in selecting targets for pharmacologic treatment of type 2 diabetes.

Obesity associated with elevated CVD mortality, morbidity

Obesity is affiliated with elevated morbidity, cardiovascular disease related mortality, and shorter longevity compared with individuals with a normal body mass index.

Bacterial vaginosis may alter links between contraception, HIV acquisition

Bacterial vaginosis may cause an increased risk for HIV acquisition in women taking oral or injectable hormonal contraception.

HbA1C levels linked to cognitive decline in diabetes

HbA1C, diabetes status, and cognitive decline during a span of 10 years were compared using data from the English Longitudinal Study of Ageing.

Standards of Medical Care in Diabetes modified for cardiovascular disease

The ADA's updates include a modified patient-focused care algorithm as well as improved risk management for CVD.

Weight loss in obese individuals associated with reduced chronic pain

Weight loss in obese individuals may lead to reduced pain, affect, and somatic symptoms associated with chronic pain.

Pediatric obesity rate may decrease with special nutrition programs

Severe obesity may decline in children enrolled in specialized diet programs.

High fitness level associated with lower waist circumference, independent of BMI

The investigators studied the association between abdominal fat, inflammation, and fitness by measuring body weight, dimensions, and blood samples.

Prostate cancer recurrence linked to metabolic syndrome, obesity

A positive correlation between increased BMI and risk of prostate cancer recurrence was observed in patients undergoing radical prostatectomy.

Comorbidity risks increase in children with psoriasis

Some of the comorbidities include increased lipid levels, hypertension, and diabetes.

Gastric bypass vs sleeve gastrectomy in morbidly obese patients

There is no statistically significant difference in weight loss at 5 years after laparoscopic sleeve gastrectomy vs laparoscopic Roux-en-Y gastric bypass in morbidly obese patients.

FDA approves shock wave device to treat diabetic foot ulcers

The FDA has approved the Dermapace System for treatment of chronic, full-thickness diabetic foot ulcers.

Mediterranean, DASH diets ranked first in Best Diets Rankings

More than 40 diet plans across 9 categories have been ranked to help those dieting achieve healthier lifestyles in U.S News & World Report.

Obesity in preschoolers leads to exacerbated asthma

Overweight/obese preschools have greater asthma symptoms than normal-weight children when untreated.

Vitamin D, calcium supplements do not reduce fracture risk in older adults

Findings do not support routine vitamin D and calcium supplementation in community-dwelling older adults for lowering the incidence of osteoporosis-related fractures.

FDA approves new "follow-on" insulin for diabetes

The new FDA approved short-acting insulin drug can be used to treat T1 and T2 diabetes.

BMI may not indicate obesity in postmenopausal women

Body mass index BMI at a cut-point of 30 kg/m2 may not be an appropriate indicator of obesity in postmenopausal women.

Better lipid profiles with almond and chocolate consumption

Cocoa, dark chocolate, and raw almonds may help improve lipid profiles in overweight individuals.

Adult obesity possible for about 50% of today's children

Adult obesity by age of 35 is likely in about 57% of today's children.

Menopausal hormone therapy for chronic conditions: USPSTF's final recommendation

The USPSTF has updated its recommendations on the use of menopausal hormone therapy for the primary prevention of chronic conditions.

FDA approves weekly diabetes drug that may also be beneficial for weight loss

The FDA has approved semaglutide injection as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Oral insulin does not prevent type 1 diabetes in relatives of patients

Oral insulin usage does not prevent the development of type 1 diabetes in relatives of patients.

Low-fat diets may reduce all-cause mortality risk in obese patients

Weight-loss diets low in fat and saturated fat consumption, with or without added exercise, may reduce the risk for all-cause mortality in obese adults.

USPSTF recommends osteoporosis screening, testing in women aged 65 and older

The USPSTF has updated its recommendations on osteoporosis screening and testing in women and men.

Overweight, obesity-related cancers increasing in the United States

Incidence rates of overweight- and obesity-related cancers have increased in the United States.

Underweight women have high risk of early menopause

Early menopause risk is highest in weight-cycling and severely underweight women.

Commercial weight loss program may help prevent diabetes in obese patients

Primary care referral to Weight Watchers meetings is associated with weight loss, HbA1c reduction.

Short-term probiotics linked to lower fat percentage in overweight, obese patients

The meta-analysis showed that short-term probiotic supplementation reduced body weight, BMI, and fat percentage, but the effect sizes were small.

Statins associated with increased risk of diabetes in high-risk individuals

Statins are associated with an increased risk for developing type 2 diabetes, especially for high-risk individuals.

Halloween tips for children with diabetes

With a little creativity, children with diabetes can enjoy the festivities of Halloween.

Diminished ovarian reserve not associated with infertility

Among women who are attempting to conceive naturally, diminished ovarian reserve is not associated with infertility.

Antidepressant use linked to type 2 diabetes in young adults

Type 2 diabetes risk is increased in young adults through antidepressant use, specifically the duration of use and the cumulative dose.

Cognitive behavioral group therapy ineffective for weight maintenance in type 2 diabetes

CBGT did not prevent overweight and obese patients with type 2 diabetes from regaining weight lost during weight loss programs.

Diabetes risk greater in children, young adults on second-generation antipsychotics

Type 2 diabetes is greater with second-generation antipsychotics than with non-second-generation antipsychotic psychotropic medications for patients aged 6 to 25 years.

AAP releases list of 5 unnecessary endocrine-related tests

The AAP Section for Endocrinology compiled the list of tests for height and puberty, which should prompt careful discussion between parents and physicians.

Insulin pump linked to better glycemic control in young patients with type 1 diabetes

Insulin pump therapy is linked to lower risks of severe hypoglycemia and diabetic ketoacidosis and better glycemic control than insulin injection therapy.

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