Epilepsy

Fycompa Approved for Younger Epilepsy Patients With Partial-Onset Seizures

Fycompa Approved for Younger Epilepsy Patients With Partial-Onset Seizures

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Safety data for Fycompa was consistent with the safety profile in adult populations without the need for weight-based dosing.

NDA Submitted for Valtoco Nasal Spray to Treat Acute Repetitive Seizures

NDA Submitted for Valtoco Nasal Spray to Treat Acute Repetitive Seizures

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The Company states that the NDA is supported by robust clinical trial data, including patients studies where more than 1600 seizures were treated with Valtoco nasal spray.

Outcomes After Seizure Recurrence Upon AED Withdrawal Following Temporal Lobectomy

Outcomes After Seizure Recurrence Upon AED Withdrawal Following Temporal Lobectomy

Recurrence of seizures was reported in 28.2% of patients who attempted withdrawal.

Late-Onset Epilepsy Linked to <i>APOE</i> ε4, Smoking, Diabetes

Late-Onset Epilepsy Linked to APOE ε4, Smoking, Diabetes

The risk for late-onset epilepsy was lower in patients with higher physical activity levels and moderate alcohol intake.

Folic Acid Supplementation May Protect Against Language Delay in AED-Exposed Children

Folic Acid Supplementation May Protect Against Language Delay in AED-Exposed Children

The odds of language delay were lower at 18 months and 36 months in children exposed to AEDs in utero whose mothers took folic acid.

Brivaracetam Effective for Reducing Seizures in Patients with Epileptic Encephalopathies

Brivaracetam Effective for Reducing Seizures in Patients with Epileptic Encephalopathies

Although 2 patients experienced an increase in seizure frequency, the remaining patients did not experience a change in frequency.

Treatment of New-Onset Epilepsy: AAN, AES Update Practice Guidelines

Treatment of New-Onset Epilepsy: AAN, AES Update Practice Guidelines

An expert subcommittee was formed consisting of members of the AAN and AES to update the 2004 evidence-based guidelines on epilepsy treatment with AEDs.

Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths

Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths

Causes of death in patients with epilepsy were assessed to determine the presence of cardiac pathology.

Epilepsy Associated With Increased Risk of Unnatural Death

Epilepsy Associated With Increased Risk of Unnatural Death

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Patients with epilepsy have a greater risk of unnatural mortality than individuals without the disorder and should take greater precautions when taking certain medications.

In Utero Exposure to Multiple AEDs, Sodium Valproate Linked to Poor Educational Attainment in Childhood

In Utero Exposure to Multiple AEDs, Sodium Valproate Linked to Poor Educational Attainment in Childhood

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In utero exposure to AEDs in combination, or sodium valproate alone, is associated with a significant decrease in attainment in national educational tests for 7-year-old children.

Code Stroke System Reduces Post-Stroke Epilepsy Risk in Older Adults

Code Stroke System Reduces Post-Stroke Epilepsy Risk in Older Adults

The adjusted analysis also demonstrated that the code stroke system was associated with a decreased risk for post-stroke epilepsy within 5 years of stroke.

Cannabinoids May Decrease Seizure Frequency in Refractory Epilepsy

Cannabinoids May Decrease Seizure Frequency in Refractory Epilepsy

A reasonable proportion of patients with epilepsy who have received treatment with pharmaceutical-grade cannabidiol products along with antiepileptic drugs have experienced a decrease in seizure frequency.

Cerebral palsy, epilepsy risk associated with lower Apgar score

Cerebral palsy, epilepsy risk associated with lower Apgar score

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An inverse relation was observed between epilepsy and cerebral palsy and 5-minute and 10-minute Apgar scores.

Influenza vaccine not associated with increased risk of epilepsy in children

No increased risk of incident epilepsy was seen among children who received influenza vaccination during the 2009-2010 influenza season in Norway.

Long-term memory enhanced by electrical stimulation of the amygdala

Long-term memory enhanced by electrical stimulation of the amygdala

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Modulate electrical stimulation of the amygdala may improve declarative memory without provoking any emotional reaction.

Delayed treatment after epileptic seizure onset leads to higher mortality rate

Delayed treatment after epileptic seizure onset leads to higher mortality rate

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Ill-timed administration of benzodiazepine treatment in pediatric patients with refractory convulsive status epilepticus is associated with many short-term adverse events.

Non-pharma therapies may offer seizure relief for children with epilepsy

Non-pharma therapies may offer seizure relief for children with epilepsy

Non-pharmaceutical treatments improved 4 cognitive and behavioral domains in children with epilepsy.

Risk of premature birth, SGA with antiepileptic drugs

Risk of premature birth, SGA with antiepileptic drugs

Women on AEDs during pregnancy are at a higher risk of delivering prematurely and giving birth to SGA newborns.

Practice guideline released for sudden unexpected death in epilepsy

Practice guideline released for sudden unexpected death in epilepsy

The guideline highlights the incidence, risk factors, and preventive approaches of SUDEP.

Cannabis-based medicine may reduce seizures in certain epilepsy patients

Cannabis-based medicine may reduce seizures in certain epilepsy patients

Cannabidiol appears to reduce seizures for some patients with Lennox-Gastaut syndrome.

Drugs advised after first seizure

Drugs advised after first seizure

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Taking epilepsy medication after a first seizure decreases the risk of another seizure.

Folic acid during pregnancy


Folic acid during pregnancy


Folic acid supplementation at least one month prior to conception is recommended.

Soldier's seizures mistakenly thought to be caused by poisonous powder

Physician assistant evaluation revealed disorder's true source.

Bacterial meningitis complicated by seizures and confusion

Bacterial meningitis complicated by seizures and confusion

The seizures began following surgery to repair a cerebrospinal fluid leak.

Adjunctive therapy for epilepsy

Adjunctive therapy for epilepsy

Vimpat is used in the treatment of partial-onset seizures.

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