Gastroenterology

McCune-Albright Syndrome Linked to Broad Range of Gastrointestinal Pathologies

McCune-Albright Syndrome Linked to Broad Range of Gastrointestinal Pathologies

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Intraductal papillary mucinous neoplasms and numerous gastrointestinal tumors have been linked to somatic gain-of-function GNAS mutations, which can lead to McCune-Albright syndrome.

Secretagogues Compared in Irritable Bowel Syndrome With Constipation

Secretagogues Compared in Irritable Bowel Syndrome With Constipation

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While several secretagogues have been recently approved by the Food and Drug Administration (FDA), a lack of head-to-head trials led researchers to conduct a systematic review to compare the effectiveness of these agents in patients with IBS-C.

Xerava Approved for the Treatment of Complicated Intra-Abdominal Infections

Xerava Approved for the Treatment of Complicated Intra-Abdominal Infections

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Eravacycline was well-tolerated in clinical trials and achieved high cure rates in patients with Gram-negative pathogens (including resistant strains).

Computer-Aided Colonoscopy Reliably Identifies Small Polyps

Computer-Aided Colonoscopy Reliably Identifies Small Polyps

Diagnosing, but leaving these polyps can save time and, likely, costs.

ASMBS Pediatric Committee Updates Guidelines on Bariatric Surgery in Teens

ASMBS Pediatric Committee Updates Guidelines on Bariatric Surgery in Teens

The American Society for Metabolic and Bariatric Surgery Pediatric Committee has updated their 2012 evidence-based guidelines.

FDA to Review Gimoti for Diabetic Gastroparesis in Adult Women

FDA to Review Gimoti for Diabetic Gastroparesis in Adult Women

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The FDA has set a Prescription Drug User Fee Act target date of April 1, 2019.

Proton Pump Inhibitor Treatment and Aspirin Improve Outcomes in Barrett Esophagus

Proton Pump Inhibitor Treatment and Aspirin Improve Outcomes in Barrett Esophagus

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High-dose esomeprazole taken in combination with aspirin may safely and effectively improve outcomes in patients with Barrett esophagus.

Bariatric surgery linked to significant reduction in microvascular complications of type 2 diabetes

Patients who received gastric bypass surgery had lower rates of diabetic neuropathy at follow up that remained stable throughout the study.

Gut Microbiota Alterations May Not Be Enough to Relieve Irritable Bowel Syndrome

Gut Microbiota Alterations May Not Be Enough to Relieve Irritable Bowel Syndrome

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As fecal microbiota transplantation has been found to be effective in treating a number of gastrointestinal diseases, such as Clostridium difficile infection, researchers are now assessing whether it may also be effective for patients with irritable bowel syndrome.

Rotavirus Vaccination Linked to Decrease in Hospitalizations

Rotavirus Vaccination Linked to Decrease in Hospitalizations

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A significant decline in rotavirus disease-associated hospitalization, emergency department visits, and physician office visits was demonstrated in children younger than 5 years following implementation of the rotavirus vaccine.

Updated Diagnostic Guidelines for Eosinophilic Esophagitis: Outcomes From AGREE

Updated Diagnostic Guidelines for Eosinophilic Esophagitis: Outcomes From AGREE

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AGREE [A Working Group on PPI-REE) was convened to update the previously published guidelines on diagnostic criteria for eosinophilic esophagitis.

Interrelationship Between Celiac Disease, Self-Reported Wheat Sensitivity, and Functional GI Disorders

Interrelationship Between Celiac Disease, Self-Reported Wheat Sensitivity, and Functional GI Disorders

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Individuals with clinically diagnosed celiac disease are at greater risk for chronic gastrointestinal symptoms, possibly fitting modified Rome criteria for irritable bowel syndrome and functional dyspepsia.

Fidaxomicin Effective for Long-Term Cure of <i>Clostridium difficile</i>

Fidaxomicin Effective for Long-Term Cure of Clostridium difficile

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Fidaxomicin demonstrated the strongest evidence for being the most effective treatment in providing a long-term cure for C difficile infection.

Risk of CRC, Non-CRC Death Increases With Positive Fecal Hemoglobin Test

Risk of CRC, Non-CRC Death Increases With Positive Fecal Hemoglobin Test

Positive guaiac fecal occult blood test result linked to increased risk of death from circulatory, respiratory, other diseases.

Harms Reporting Limited in Trials of Prebiotics, Probiotics, Synbiotics

Harms Reporting Limited in Trials of Prebiotics, Probiotics, Synbiotics

No harms-related data reported for 28% of trials; safety results not reported for 37%.

FDA: Illnesses Tied to Fresh Crab Meat Imported From Venezuela

FDA: Illnesses Tied to Fresh Crab Meat Imported From Venezuela

Illnesses appear to be caused by Vibrio parahaemolyticus bacteria.

Is New Surveillance Monitoring Required for Enterococcal Oxazolidinone Resistance?

Is New Surveillance Monitoring Required for Enterococcal Oxazolidinone Resistance?

A study was conducted to evaluate the oxazolidinone resistance mechanisms of enterococci bacteria.

Budesonide ER for Ulcerative Colitis Safe Regardless of Gender, Age

Budesonide ER for Ulcerative Colitis Safe Regardless of Gender, Age

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The budesonide extended-release formulation was found to be safe and well tolerated for the remission of ulcerative colitis, regardless of age or gender.

Rifaximin May Improve Abdominal Pain Symptoms in IBS-D

Rifaximin May Improve Abdominal Pain Symptoms in IBS-D

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A 2-week course of treatment with rifaximin for diarrhea-predominant irritable bowel syndrome was found to improve abdominal pain symptoms.

CDC Issues Update for Resistant <i>Shigella</i> Infections

CDC Issues Update for Resistant Shigella Infections

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The CDC has identified an increasing number of Shigella isolates that test within the susceptible range for the fluoroquinolone antibiotic ciprofloxacin.

<i>C difficile</i> Risk Higher With Stoma Reversal vs Colectomy

C difficile Risk Higher With Stoma Reversal vs Colectomy

Findings based on examination of 30-day postoperative period in large cohort

Gastroesophageal Reflux in Preterm Infants: Diagnosis and Management

Gastroesophageal Reflux in Preterm Infants: Diagnosis and Management

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The American Academy of Pediatrics releases a new clinical report on the diagnosis and treatment of clinically significant gastroesophageal reflux.

Restricting perioperative fluid for abdominal surgery patients does not reduce complications: The RELIEF trial

Among patients at increased risk for complications undergoing abdominal surgery, those randomized to perioperative fluid restriction did not have increased disability-free survival at one year compared to patients who received liberal perioperative fluid management.

Higher Vitamin D Levels Tied to Lower Risk of Colorectal Cancer

Higher Vitamin D Levels Tied to Lower Risk of Colorectal Cancer

In women, risk declines as levels increase up to 100 nmol/L, but association in men not significant

Case Study: Sudden Abdominal Pain

Case Study: Sudden Abdominal Pain

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A 90-year-old woman with a history of coronary disease and gallstones presents to the emergency department with generalized abdominal pain that started suddenly about 7 hours prior.

Microbiota in Breastfed Infants May Help Prevent Overweight

Microbiota in Breastfed Infants May Help Prevent Overweight

Elevated risk of overweight for formula-fed infants attenuated with adjustment for gut microbiota

ACS Updates Colorectal Cancer Screening to Start at Age 45

ACS Updates Colorectal Cancer Screening to Start at Age 45

Average-risk adults aged 45 should undergo high-sensitivity stool-based test, structural exam

Obesity Treatment Education, Training Needed in PA Programs

Obesity Treatment Education, Training Needed in PA Programs

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Recognizing the obesity epidemic and educating physician assistants on the implications of this condition and how they should be caring for obese patients should be prioritized, according to the study authors.

Higher CRC Risk With Advanced Adenoma Found on Colonoscopy

Higher CRC Risk With Advanced Adenoma Found on Colonoscopy

Risk not increased for non-advanced adenoma found on colonoscopy following flex sigmoidoscopy

Stat Consult: Parenteral Nutrition Issues

Stat Consult: Parenteral Nutrition Issues

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Some include mechanical complications, central vascular access complications, and compatibility issues.

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