Narcan® (naloxone HCl) Nasal Spray will be available for over-the-counter (OTC) emergency treatment of known or suspected opioid overdose beginning in September.

Narcan Nasal Spray is an opioid antagonist that reverses the effects of opioids, including respiratory depression, sedation, and hypotension. The approval for nonprescription use was supported by more than 7 years of postmarketing data demonstrating the safety and efficacy of Narcan, along with human factors studies.

Studies showed that consumers were able to understand how to use Narcan safely and effectively without supervision by a health care provider.

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The OTC product is supplied in a 4mg dosage strength using the same device as the prescription product. The manufacturer’s suggested retail price is $44.99 per carton; each carton contains 2 doses.

“A steadfast commitment to expanding access to naloxone has always been at the forefront of our work to help save lives and we’re proud to bring Narcan® Nasal Spray to many, many more places,” said Paul Williams, senior vice president, products business.

A generic equivalent to Narcan Nasal Spray was recently made available OTC as well by Padagis LLC.


Emergent BioSolutions’ Narcan® Nasal Spray launches over the counter making it possible for everyone to help save a life from an opioid overdose emergency. News release. Emergent BioSolutions. August 30, 2023. Accessed August 31, 2023.

This article originally appeared on MPR