Hematology

Updated Clinical Practice Guidelines for Venous Thromboembolism: Pregnant and Pediatric Patients

Updated Clinical Practice Guidelines for Venous Thromboembolism: Pregnant and Pediatric Patients

In this 3-part series, Hematology Advisor spoke with experts about the revisions to the ASH clinical practice guidelines for venous thromboembolism.

Identifying Risk Factors for Cytomegalovirus Antigenemia in Pediatric Patients

Identifying Risk Factors for Cytomegalovirus Antigenemia in Pediatric Patients

Researchers assessed risk factors for cytomegalovirus antigenemia in pediatric patients.

Anemia Criteria Assist Decision on Type of Colorectal Cancer Screen

Anemia Criteria Assist Decision on Type of Colorectal Cancer Screen

Risk for proximal cancers low among patients without broad-definition anemia and/or abdominal mass.

New Law Boosts Fight Against Sickle Cell Disease

New Law Boosts Fight Against Sickle Cell Disease

In 2018, the National Institutes of Health was funded approximately 115 million for research of the disease.

Induction Chemotherapy Is Well Tolerated in Elderly Patients With Acute Myeloid Leukemia

Induction Chemotherapy Is Well Tolerated in Elderly Patients With Acute Myeloid Leukemia

The researchers reported more than 75% of patients achieved complete response after 1 cycle of the intensive chemotherapy regimen.

Western Culture, Not Age, Linked to Elevated Blood Pressure

Western Culture, Not Age, Linked to Elevated Blood Pressure

Members of 2 remote Venezuelan tribes were found to have elevated blood pressure following exposure to Western culture.

Smartphone App Uses Fingernail Bed Images to Detect Anemia

Smartphone App Uses Fingernail Bed Images to Detect Anemia

App uses color and metadata from fingernails to detect hemoglobin levels in the blood.

ASH: New Venous Thromboembolism Clinical Practice Guideline

ASH: New Venous Thromboembolism Clinical Practice Guideline

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The guidelines were developed by over 100 experts, including hematologists, patient representatives, and other specialists.

USPSTF: Evidence Lacking for Lead Screen in Kids, Pregnancy

USPSTF: Evidence Lacking for Lead Screen in Kids, Pregnancy

The US Preventive Services Task Force (USPSTF) has concluded that current evidence is insufficient for assessing the balance of harms and benefits of screening for elevated blood lead levels in asymptomatic children and pregnant women.

Case Study: Abdominal Pain, Malaise, and a Bruise on the Leg

Case Study: Abdominal Pain, Malaise, and a Bruise on the Leg

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A 44-year-old man presents to the hospital with generalized abdominal pain, malaise, subjective low-grade fever, and a bruise on his left shin. He has an extensive medical history including HIV, hypertension, diabetes, and GERD, but he denies vomiting or diarrhea.

ASPREE Trial: Aspirin Associated With Higher Mortality, Hemorrhage Risk in Older Adults

ASPREE Trial: Aspirin Associated With Higher Mortality, Hemorrhage Risk in Older Adults

The use of aspirin in healthy elderly patients as a preventative strategy was associated with no prolongation of long-term disability-free survival compared with placebo.

Fostamatinib Seems Effective for Immune Thrombocytopenia

Fostamatinib Seems Effective for Immune Thrombocytopenia

Overall response of platelet count 50,000/L seen in 43% of patients.

Emicizumab Prophylaxis Cuts Bleeding in Hemophilia A

Emicizumab Prophylaxis Cuts Bleeding in Hemophilia A

Lower bleeding rate with administration once weekly, every 2 weeks vs no prophylaxis.

Elevated Late Mortality Persists After Blood or Marrow Transplant

Elevated Late Mortality Persists After Blood or Marrow Transplant

But in past 3 decades, decrease in late mortality seen among those who underwent BMT in childhood.

L-Glutamine Oral Therapy Reduces Sickle Cell-Related Pain Better Than Placebo

L-Glutamine Oral Therapy Reduces Sickle Cell-Related Pain Better Than Placebo

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L-Glutamine oral treatment with or without hydroxyurea reduces pain crises better than placebo in individuals with sickle cell disease.

Decrease in Mean Platelet Counts Seen During Pregnancy

Decrease in Mean Platelet Counts Seen During Pregnancy

Platelet counts of 150,000/mm at time of delivery more common with pregnancy-related complications

FDA Permits Marketing of Devices to Create Arteriovenous Fistula

FDA Permits Marketing of Devices to Create Arteriovenous Fistula

Two devices designed to create arteriovenous fistula in patients with CKD in need of hemodialysis

Clotting Time in Transfemoral PCI Linked to Bleeding Risk

Clotting Time in Transfemoral PCI Linked to Bleeding Risk

More major bleeding seen at maximal activated clotting time greater than 290 seconds.

FDA: Updated Safety Alert Regarding Benzocaine-Associated Methemoglobinemia

FDA: Updated Safety Alert Regarding Benzocaine-Associated Methemoglobinemia

The Agency is urging manufacturers to stop marketing OTC oral drug products containing benzocaine for teething to this patient population.

Oral Anticoagulation: Reversing the Current View in Bleeding Events

Oral Anticoagulation: Reversing the Current View in Bleeding Events

Advances in new reversal agents will be key for managing patients treated with DOACs to prevent major bleeding events.

CDC: Recommendations on the Use of Heplisav-B Published

CDC: Recommendations on the Use of Heplisav-B Published

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Benefits of protection with 2 doses administered over 1 month make the vaccine an important option for prevention of HBV.

Gene Therapy May Eliminate Blood Transfusion Needs in Severe β-Thalassemia

Gene Therapy May Eliminate Blood Transfusion Needs in Severe β-Thalassemia

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With use of CD34+ cells via BB305 vector transduction, patients with severe β-thalassemia may no longer require long-term RBC transfusions as frequently or at all.

Hypertension Increase in Children Based on 2017 AAP Guidelines

Hypertension Increase in Children Based on 2017 AAP Guidelines

Increase in estimated population prevalence of elevated blood pressure from 11.8 to 14.2%.

Predicting mortality and outcomes after a subarachnoid hemorrhage

Predicting mortality and outcomes after a subarachnoid hemorrhage

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A clinical prediction tool successfully forecasts subarachnoid hemorrhage management from ruptured intracranial aneurysms.

VTE risk linked to increased television watching

VTE risk linked to increased television watching

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Increased frequency of television viewing may be linked to an increased risk for venous thromboembolism.

Pharmacomechanical thrombolysis does not reduce post-thrombotic syndrome in DVT

Pharmacomechanical thrombolysis does not reduce post-thrombotic syndrome in DVT

The addition of pharmacomechanical thrombolysis does not reduce the risk of post-thrombotic syndrome among patients with acute proximal deep vein thrombosis.

Case Study: Diarrhea and rash

Case Study: Diarrhea and rash

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A 60-year-old man with a history of gastroesophageal reflux disease presents to the emergency department with 2 to 3 days of fever, non-bloody diarrhea, and a worsening non-pruritic rash.

FDA approves new hemophilia A drug with factor VIII inhibitors

FDA approves new hemophilia A drug with factor VIII inhibitors

New FDA-approved prophylactic treatment decreases bleeding episodes hemophilia A patients with factor VIII inhibitors.

Assessing and treating disorders of primary hemostasis

Assessing and treating disorders of primary hemostasis

An evaluation begins with a focused history and physical examination, CBC count with platelet trend, and examination of the peripheral smear.

Warfarin associated with lower cancer risk in older adults

Warfarin associated with lower cancer risk in older adults

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Warfarin use may provide cancer protection across a broad range of malignant neoplasms.

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