Hematology/Oncology News Archive

Cancer Development Linked to Increased Diabetes Risk

Increased risk of subsequent diabetes independent of traditional diabetes risk factors

Smartphone App Effectively Teaches Visual Diagnosis of Melanoma

A smartphone application is a more effective learning tool for accurately diagnosing melanoma compared with traditional, rule-based methods.

Prophylactic, Extended Carboplatin Infusion Not Linked to Lower HSR in Ovarian Cancer Patients

A prophylactic, graded, extended infusion of carboplatin, compared with a shorter, standard infusion, is not associated with a reduced rate of HSRs in women with recurrent ovarian cancer.

Cryoablation Efficacious for Cancer Pain, Review Finds

Cryoablation also cuts the need for opioids at 24 hours post-treatment and at three months

Lyme Neuroborreliosis: Long-Term Survival and Health Outcomes

Lyme neuroborreliosis diagnosis had no substantial effect on long-term survival, health, or educational/social functioning yet may be associated with an increased risk of hematologic and nonmelanoma skin cancers.

FDA Warns Companies Promoting Ineffective "Sunscreen Pills"

Alternative sun protection products, including pills and dietary supplements, are misleading consumers through false marketing and advertising.

Many Breast Cancer Survivors Do Not Undergo Annual Surveillance

In year 1, 13% did not undergo MRI or mammography; up to 19% by year 5.

ACS Updates Colorectal Cancer Screening to Start at Age 45

Average-risk adults aged 45 should undergo high-sensitivity stool-based test, structural exam

Severe Folate Deficiency Associated With Olaparib for Relapsed Ovarian Cancer

In a case study, olaparib was found to induce folate deficiency in most patients with relapsed ovarian cancer. Researchers discuss the significance of this adverse effect and how it was managed.

Male Thyroid Cancer Survivors Face Higher CVD Risk

Age at diagnosis, sex, BMI, and thyroid-stimulating hormone suppression therapy affect CVD risk

ACC Outlines Best Practices for Ionizing Radiation Use in Cardiovascular Imaging

The American College of Cardiology, along with several other cardiology societies, have updated guidelines on best practices for improving safety when using ionizing radiation during cardiovascular imaging.

PSA Level 3 Months After Radiation Treatment May Predict Outcome

Findings for men with intermediate- and high-risk prostate cancer

Lung Cancer Incidence Higher for Young Women Than Young Men

Crossover in sex-specific rates among US non-Hispanic whites born since 1965

Hand Grip Strength Associated With All-Cause Mortality, Other Adverse Outcomes

Grip strength is strongly and inversely associated with all-cause mortality and incidence of and mortality from cardiovascular disease, respiratory disease, COPD, all cancer, and subtypes of cancer, with associations being modestly stronger in the younger age groups.

Higher CRC Risk With Advanced Adenoma Found on Colonoscopy

Risk not increased for non-advanced adenoma found on colonoscopy following flex sigmoidoscopy

AAPA Responds to JAMA Dermatology Study

AAPA and SDPA respond to a recent article published in JAMA Dermatology.

Many Oncologists Discuss, Recommend Medical Marijuana

But majority of oncologists don't feel knowledgeable enough to make these recommendations

Ovarian Cancer Patients May Benefit From Trabectedin With PLD

For patients with platinum-sensitive recurrent ovarian cancer, trabectedin plus PLD may be beneficial.

Highly Selective, First-in-Class CDK4 Inhibitor Promising in Ovarian Cancer

Mice treated with 2-94 had few or no signs of lymphopenia or neutropenia, common adverse events associated with palbociclib.

Personalized Cancer Vaccine Looks Promising in Early Study

The researchers enrolled 25 platinum-pretreated, immunotherapy-naïve patients with recurrent advanced epithelial ovarian cancer (EOC) for the trial.

FDA Targets Clinics Offering Unapproved Stem Cell Therapies

Clinics claim unapproved therapies can treat number of diseases and conditions, including ALS and cancer

Chronic Aspirin Exposure Linked to Melanoma Risk in Males

Significantly increased risk of malignant melanoma in males, but not females, on once-daily aspirin

PAs Have Lower Diagnostic Accuracy for Melanoma Compared With Dermatologists

Compared with dermatologists, physician assistants perform more skin biopsies but detect fewer melanomas.

Long-Term Cardiovascular Risk for Endometrial Cancer Survivors

Elevated risk of various cardiovascular outcomes, including pulmonary heart disease, atrial fibrillation

Screening for Prostate Cancer: USPSTF Recommendation Statement

The USPSTF has updated its 2012 recommendations on prostate-specific antigen (PSA)-based screening for prostate cancer.

Intrathecal Drug Delivery and Spinal Cord Stimulation for Cancer Pain: A Review

Intrathecal drug delivery systems and spinal cord stimulation have shown promise for the treatment of cancer pain in initial studies.

Flexible Sigmoidoscopy Cuts CRC Incidence, Mortality in Men

Absolute risks for colorectal cancer, CRC death not reduced for screening group vs controls in women

Adjuvant Pembrolizumab Beneficial in Stage III Melanoma

Pembrolizumab linked to significantly longer recurrence-free survival at 15-month follow-up

Advanced Ovarian Cancer Survival Rates Longer After Primary Cytoreductive Surgery Compared With Neoadjuvant Chemotherapy

Researchers found a superior survival rate in patients who received primary cytoreductive surgery as opposed to neoadjuvant chemotherapy for stage IIIC and IV high-grade serous ovarian carcinoma.

FDA Approves Multi-Cancer Treatment Drug

The FDA has approved Rubraca, a poly (ADP-ribose) polymerase inhibitor, to treat patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer.

Pap Tests May Help Diagnose Endometrial, Ovarian Cancers

Genetic mutations assays using PapSEEK may facilitate the detection of certain cancers using fluids from Pap tests.

Vigil Immunotherapy and PARP 7 Treatments for Patients with Ovarian Cancer

Vigil immunotherapy is possible for women with recurrent ovarian cancer and PARP 7 may impact ovarian cancer survival, according to two studies presented in New Orleans.

Prostate-specific antigen screening helps prostate cancer detection

Prostate cancer was diagnosed more frequently in men who underwent single prostate-specific antigen screening than in those who did not, but mortality was unaffected.

Behavioral Counseling for Skin Cancer Prevention: USPSTF Updated Recommendations

The USPSTF has updated both the 2012 recommendation on behavioral counseling for the primary prevention of skin cancer and the 2009 recommendation on screening for skin cancer with skin self-examination.

NCCN's anticancer drug recommendations beyond FDA approval based on weak evidence

Does weak evidence drive the NCCN recommendations of FDA-approved drugs?

Gap identified in colorectal cancer screening among low-income populations

Improving colorectal cancer screening rates among lower-income populations requires addressing structural, personal, and health care system barriers.

Colorectal cancer screening doubled with use of a digital health program

The use of the Mobile Patient Technology for Health-CRC (mPATH-CRC) digital health program doubles the proportion of patients who completed colorectal cancer (CRC) screening.

Colorectal cancer risk in veterans significantly reduced with colonoscopy screening

Colonoscopy is associated with significant reductions in colorectal cancer mortality among veterans and with greater benefit for left-sided cancer than right-sided cancer.

High vitamin D concentration associated with lower cancer risk

A higher concentration of plasma vitamin D is correlated with a decreased risk of total cancer.

Aggressive treatment not beneficial for metastatic prostate cancer

For men with metastatic prostate cancer, aggressive therapy has no significant advantage over conservative androgen deprivation only treatments.

Cooling therapy for hand-foot syndrome prevention, management

For patients with ovarian cancer taking pegylated liposomal doxorubicin who have hand-foot syndrome, frozen gloves and socks is a safe method of treatment.

Ovarian cancer may be paternally inherited

The disease allele may be passed from affected grandmother to granddaughter through the father's inherited genes.

Cancer history affects mortality risk independent of CV risk

Cancer history has an important impact on mortality independent of cardiovascular risk factors.

Ultra-processed foods may increase overall, breast cancer risks

An increased consumption of processed foods by 10% was associated with more than 10% increased risk for overall and breast cancers.

Ovarian cancer risk reduced with oral contraceptives

The use of oral contraceptives did not reduce the risks of breast cancer or colorectal cancer.

Ovarian cancer screening: updated recommendations from the USPSTF

The USPSTF has issued an updated recommendation statement on ovarian cancer screening.

Primary gastrinomas of the hepatobiliary tract may occur in patients with Zollinger-Ellison syndrome

Lymph nodes proximal to hepatic or biliary gastrinomas will likely require extraction as many in the surround region will have metastasized.

Assessing the impact of antidepressants on ovarian cancer risk

Past epidemiological investigations resulted in inconsistent reports on the affiliation between antidepressants and the risk of ovarian cancer.

Ovarian cancer patients may benefit from added hyperthermic intraperitoneal chemotherapy

The addition of HIPEC resulted in longer recurrence-free and overall survival among patients with ovarian cancer.

Prostate cancer recurrence linked to metabolic syndrome, obesity

A positive correlation between increased BMI and risk of prostate cancer recurrence was observed in patients undergoing radical prostatectomy.

Guidelines for basal, cutaneous squamous cell carcinoma management

Guidelines were provided for basal cell carcinoma and cutaneous squamous cell carcinoma.

Depressive symptoms may predict mortality in head, neck cancer

Depressive symptoms at the time of treatment planning can predict overall 2 year mortality in patients with head and neck cancer.

Clinical tool may help in prostate cancer screenings

Polygenic hazard scores were developed to help predict the age of onset of prostate cancer.

Multi-analyte blood test detects 8 common cancers

A multi-analyte blood test, CancerSEEK, can detect 8 common cancer types, with high sensitivity and specificity.

BRCA might not affect young-onset breast cancer survival rates

Both patients with and without BRCA mutations have comparable survival rates.

Cancer risk in women who work night shifts long-term

For women who work night shifts, breast cancer risks increase by 3.3% for every 5 years of work.

Skin cancer risk higher in patients with atopic dermatitis

Patients with atopic dermatitis may have a greater risk of developing squamous cell carcinoma.

Hormonal contraception use linked to an increased risk of breast cancer

Breast cancer diagnosis is higher among women who currently use or recently used contemporary hormonal contraceptives than among women who have never used hormonal contraceptives.

Nivolumab treatment for lung cancer may successfully deplete HIV reservoirs

Nivolumab treatment for non-small-cell lung cancer may induce successful depletion of HIV reservoir.

Adolescent acne not linked to malignant melanoma in men

Body mass index is linked to malignant melanoma in men.

Oxybenzone in lotion linked to dermatological, environmental toxicity

Oxybenzone, found in sunscreens and other products, has harmful dermatological and environmental effects.

FDA approves new hemophilia A drug with factor VIII inhibitors

New FDA-approved prophylactic treatment decreases bleeding episodes hemophilia A patients with factor VIII inhibitors.

ASCO: Alcohol consumption increases cancer risk

According to a special report by the American Society of Clinical Oncology, alcohol consumption is a definite risk for cancer development.

Overweight, obesity-related cancers increasing in the United States

Incidence rates of overweight- and obesity-related cancers have increased in the United States.

Vitamin D supplementation not associated with reduced cancer risk

Little evidence was found for linear causal associations between genetic determinants of circulating vitamin D concentration and risk of seven cancers.

Warfarin associated with lower cancer risk in older adults

Warfarin use may provide cancer protection across a broad range of malignant neoplasms.

AJCC melanoma staging system is revised

American Joint Commtitee on Cancer melamona staging system revised.

USPSTF recommends skin cancer prevention care to begin at age 6 months

The USPSTF has released updated recommendations on skin cancer counseling and self-examination for adults with fair skin.

Gastroesophageal adenocarcinoma patients benefit from adjuvant chemotherapy

The researchers found that patients receiving adjuvant chemotherapy for gastroesophageal adenocarcinoma were younger, more likely to have advanced disease, and had shorter postoperative inpatient stays.

Increased cancer risk found in rheumatoid arthritis patients with VTE

VTE and cancer are the result of inflammation and immunological dysfunctions associated with RA.

Pediatric inflammatory bowel disease increases cancer risk in adulthood

Patients with childhood-onset IBD have an increased risk of cancer, especially gastrointestinal cancers, lymphoid neoplasms, and skin cancer,

Cervical cancer screening: recommendations from the USPSTF

The major change includes screening with hrHPV testing alone as an alternative to cytology screening alone starting at age 30 years.

Non-hormone options available for estrogen depletion after breast cancer

A variety of non-hormone options and therapies are available for treatment of estrogen-depletion symptoms and clinical problems after a diagnosis of breast cancer.

Annual mammography from age 40 decreases breast cancer mortality

Thousands of US lives would be saved each year if women received annual mammograms starting at age 40.

Vitamin B supplements not chemopreventive for lung cancer

Vitamin B supplements are not chemopreventive and may increase cancer risk in men.

Antiemetics: a clinical practice guideline update from ASCO

The updated guidelines will help clinicians prevent and manage nausea and vomiting caused by antineoplastic agents or radiation therapy in cancer patients.

Consuming total, saturated fat increases the risk of lung cancer

The risk of lung cancer was reduced for high intake of polyunsaturated fat.

Ovarian cancer screening: a USPSTF recommendation statement

The USPSTF states that the harms of screening for ovarian cancer in asymptomatic women outweigh the benefits.

Surgery may not improve outcomes in early-stage prostate cancer

A 20-year study found that patients with early-stage prostate cancer who have surgery to remove their tumor do not live longer than those who receive no treatment.

Breast, ovarian cancer risks estimated for BRCA1/BRCA2 mutation carriers

Breast cancer risk is increased with a larger number of first- and second-degree relatives diagnosed as having breast cancer for both BRCA1/BRCA2 carriers.

Mammogram referral, screening rates boosted with point-of-care screening program

A breast cancer screening program helped improve mammography referral and screening rates in a federally qualified health center.

ASCO: Capecitabine may prolong survival in patients with biliary tract cancer

The researchers found that the average survival after surgery for those receiving capecitabine was longer compared with those who only had surgery.

One alcoholic drink per day may increase breast cancer risk

Drinking the equivalent of a small glass of wine or beer a day increases pre-menopausal breast cancer risk by 5% and post-menopausal breast cancer risk by 9%.

Nitrate inhalants (poppers) associated with increased virus-associated cancer risk in HIV-uninfected MSM

Among HIV-uninfected men aged 50 to 70, heavy popper use was associated with an increased risk of virus-associated cancer with causes linked to HPV, HHV-8, and Epstein-Barr virus.

Low-dose aspirin reduces breast cancer risk

Developing breast cancer was associated inversely with taking 3 or more tablets of low-dose aspirin per week.

Integrative therapies during and after breast cancer treatment: a clinical practice guideline

Evidence supports the routine use of mind-body practices, such as yoga, meditation, relaxation techniques, and passive music therapy, to address common mental health concerns in patients with breast cancer.

Metastatic pancreatic cancer: a new clinical practice guideline

The guideline will help clinicians determine the appropriate treatment of patients with metastatic pancreatic cancer.

USPSTF recommends individualized approach to prostate cancer screening

The USPSTF recommends that prostate cancer screenings should be an individual decision.

Vitamin D and calcium supplementation not effective for lowering cancer risk in postmenopausal women

Vitamin D and calcium did not result in a significantly lower risk of all-type cancer, including breast cancer, in postmenopausal women.

Colorectal cancer characteristics different, outcomes worse among octogenarians

Octogenarians with colorectal cancer have several differences in clinical and tumor characteristics, compared with younger patients with the disease.

Lithium not linked to increased cancer risk in patients with bipolar disorder

No difference was observed in risk of overall cancer in patients with bipolar disorder who use lithium, compared with the general population.

Additional weight may affect risk of gastrointestinal cancers

Excess weight could influence the risk of of gastrointestinal cancers by altering insulin levels and promoting inflammation.

Antiandrogen therapy improves long-term survival after prostate cancer returns

Antiandrogen therapy with daily bicalutamide to salvage radiation therapy resulted in significantly higher rates of long-term overall survival.

VA lung cancer screening program finds high rate of incidental findings, low cancer detection rate

An estimated 900,000 veterans of a population of 6.7 million VHA patients met the criteria for LCS.

Recommendations released for management of small renal masses

Researchers used data from 83 studies to develop guideline for management of patients with small renal masses.

Is vasectomy linked to risk of prostate cancer?

Vasectomy can continue to be a safe method of contraception in men.

Cancer-related deaths attributed to smoking vary across states

Cancer deaths attributed to cigarette smoking are common among the Southern states.

Abnormal uterine bleeding linked to hematologic malignancies

Women presenting with new-onset heavy menstrual bleeding plus thrombocytopenia or pancytopenia should be evaulatued for a possible hematologic malignancy.

ASCO issues guidelines for chronic pain in patients with a history of adult cancer

Screening for pain at every visit is recommended, and management and treatment options are specified.

Alcohol consumption, obesity raise risk of esophageal cancer

One-third of cases may be avoided if patients maintained a healthy weight and limited alcohol consumption.

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