Hematology/Oncology News Archive
Early screening may benefit those with dense breasts, personal/family history of breast cancer.
Pelvic ultrasonography was used to distinguish between simple cysts and more complex cysts or solid masses, which are associated with an increased risk of ovarian cancer.
In September, health experts from around the globe gathered at the 2018 World Conference on Lung Cancer in Toronto. We compiled a list of 8 key findings presented at the event.
Cancer detection rate is 8.4/1000 exams in older women; 98% of cancers surgically excised.
Immune checkpoint inhibitor pneumonitis is a potentially serious complication that may occur more in patients with lung cancer than previously suspected.
In men, overweight and even higher normal weight tied to increased risk.
The approval was based on data from the KEYNOTE-224 study, a single-arm trial in patients with HCC who had disease progression on or after sorafenib or were intolerant to sorafenib; had measurable disease; and Child-Pugh class A liver impairment.
Greatest shift to cancer as leading cause of death seen in highest-income counties in United States.
Second study shows no significant results for vitamin D supplementation vs placebo.
Efforts needed in implementing routine assessments of needs, facilitating personalized referrals.
Nine in 10 women experience multiple symptoms prediagnosis; 8 in 10 of them consult a doctor.
One-view digital breast tomosynthesis with a reduced compression force detected breast cancer with higher sensitivity and lower specificity than 2-view digital mammography.
Annual number of deaths expected to continue to decrease despite growth, aging of US population.
The use of angiotensin-converting enzyme inhibitors is associated with an increased risk for lung cancer compared with angiotensin receptor blockers.
Researchers determined that women ≥55 years of age who underwent a single HPV DNA test with a negative diagnosis as well as routine cytology were found to be at low risk for cervical cancer.
A lack of understanding of terminology, health care system distrust, and a lack of prostate cancer knowledge are among the barriers to genomic testing for prostate cancer and prostate cancer research participation among black men.
New guidelines have been released for the treatment of primary cutaneous melanoma, according to a report from the American Academy of Dermatology.
Nonprofessional experience with cancer may be associated with a lack of adherence to ovarian cancer screening guidelines.
The risk for breast cancer recurrence can be extracted using disease-specific survival data.
Surgical invasiveness might play a role in the odds of becoming a long-term opioid user after early-stage lung cancer surgery.
Tobacco use remains the leading modifiable cause of cancer and should be a priority for cancer control.
Those who do see a cardiologist are more likely to fill anticoagulant prescription and have reduced risk for stroke.
Treatment with chemotherapeutics promoted atrophy and mitochondrial damage in breast muscle cells.
For patients with metastatic triple-negative breast cancer, atezolizumab plus nanoparticle albumin-bound-paclitaxel prolongs progression-free survival compared with placebo plus nab-paclitaxel.
To investigate the link between organic food consumption and cancer risk, study authors conducted a population-based prospective cohort study among French adults.
Patients in the real world setting were initiated at a lower dose and experienced fewer side effects than trial participants.
Talzenna, a poly (ADP-ribose) polymerase (PARP) inhibitor, was evaluated in EMBRACA, an open-label trial that randomized patients with gBRCAm HER2-negative locally advanced or metastatic breast cancer (N=431) to receive talazoparib 1mg or physician's choice of chemotherapy (capecitabine, eribulin, gemcitabine, or vinorelbine).
Postmenopausal women with weight loss have a reduced risk for breast cancer.
Higher Levels of Anti-CA15.3 and Anti-CA125 Linked to Increased Risk for Mucinous Epithelial Ovarian Cancer
Researchers used the EPIC Cohort to identify whether anti-CA125 and anti-CA15.3 antibodies alone or in combination with antigens may determine epithelial ovarian cancer risk.
Among cancer survivors, illness perception may affect patient health-related quality of life and mortality.
Although ovarian cancer risk may be reduced with regular use of low-dose aspirin, the use of nonaspirin analgesics may increase the risk of ovarian cancer among long-term, high-quantity users.
The petition was submitted by a number of non-profit organizations including the Center for Science in the Public Interest and the Breast Cancer Fund.
Weight loss may indicate a cancer diagnosis in patients presenting in primary care, specifically when weight loss correlates to another cancer-related clinical feature.
82 percent of variant carriers identified in exome sequencing had not undergone prior testing.
Women with ovarian or endometrial cancer who adhere to a ketogenic diet may benefit from a selective loss of fat mass and a reduction in fasting serum insulin, while still retaining lean mass.
Almost 43% of those presenting to NCI center for second opinion have change in diagnosis.
At 6 months, rates for provoked, unprovoked, cancer-related VTE are 6.8, 6.92, 9.06 per 100 person-years.
Barriers found among PCPs in surveillance of HCC indicate the need for clinical interventions, including provider education.
Talazoparib, a poly(adenosine diphosphate-ribose) inhibitor, may significantly enhance progression-free survival in patients with advanced breast cancer and a germline BRCA1/2 mutation.
Combined hormonal contraception use tied to lower risk; risk down with increasing duration of use.
The FDA based its approval on the results of a triplet of phase 3 studies, the MONALEESA-2, MONALEESA-3, and MONALEESA-7.
For this phase 1b study, researchers enrolled 57 patients with ERBB2/HER2-positive metastatic breast cancer previously treated with trastuzumab and a taxane.
The North American Menopause Society has found that postmenopausal women with a breast cancer diagnosis may have vitamin D deficiency as well as higher rates of obesity.
Whole-exome sequencing revealed that PALB2, ATM, CHEK2, and MSH6 genes were significantly associated with an increased risk of breast cancer; MSH6, RAD51C, TP53, and ATM were found to be linked to an increased risk of ovarian cancer.
Olaparib Treatment May Improve Health-Related Quality of Life in Germline BRCA1/2-Mutated Ovarian Cancer
Olaparib, may help to improve duration of good quality of life and quality-adjusted progression-free survival in germline BRCA1/2-mutated ovarian cancer.
Odds of choosing screening up for men with family history, African descent, low socioeconomic status.
Serving patients' specific needs, such as referral to socioeconomic support, can improve care.
Diagnosing, but leaving these polyps can save time and, likely, costs.
No increased risk of cancer recurrence among RA patients initiating tumor necrosis factor inhibitor treatment.
Few differences between rural, urban patients in cancer outcomes with uniform access to cancer care.
Cytology recommended every 3 years from age 21; different screening options from age 30 to 65.
A Phase 1 study in healthy volunteers showed a favorable safety profile with no serious adverse events.
Lumpectomy, radiotherapy tied to reduction in breast cancer mortality vs lumpectomy, mastectomy.
The majority of patients with cancer who are being treated with World Health Organization Step III opioids were found to experience poor sleep quality, often due to pain.
In high-volume centers, patients with liver metastases from colorectal cancer may often be eligible for minimally invasive liver surgery via laparoscopy, thereby reducing potential morbidity risks associated with open surgery.
For cancers associated with numerous copy number changes, it is difficult to assign disease classifiers and identify useful targets for drug development.
Short intervention associated with more sunscreen use, improved patient satisfaction.
High-dose esomeprazole taken in combination with aspirin may safely and effectively improve outcomes in patients with Barrett esophagus.
C-509T allele and postoperative cosmetic surgery significantly linked to breast fibrosis risk.
No increased risk of corpus uteri, invasive breast cancer for women undergoing assisted reproduction.
Studies conducted in people have mixed results, with some indication of increased risk of ovarian cancer.
Less than a year following the initial direct-to-tumor vaccine injection, all treated tumors disappeared.
Ribociclib approved in combo with AI as endocrine tx for HR-positive, HER2-negative advanced breast CA.
10 autoantibody biomarkers together display high sensitivity, specificity.
The use of multiple sun protection measures was defined as the use of 2 or more of these measures more than 50% of the time when the individual was outdoors.
Positive guaiac fecal occult blood test result linked to increased risk of death from circulatory, respiratory, other diseases.
The Endocrine Society, European Society of Endocrinology, and Pediatric Endocrine Society issue guidelines for the management of hypothalamic-pituitary and growth disorders in childhood cancer survivors.
First-line chemotherapy in combination with bevacizumab, compared with chemotherapy alone, may benefit patients with ovarian cancer and elevated neutrophil-to-lymphocyte ratios.
An analysis of population data on cancer incidence, survival, and mortality revealed that early interventions and improvements to treatments contributed to a 26% decline in cancer deaths from 1991 to 2015.
No significant difference was identified in combination CA125/CEA ratio vs CEA alone in distinguishing ovarian neoplasms from ovarian metastases.
Study patients who received Avastin plus chemotherapy followed by Avastin alone, had a greater median PFS vs patients who received chemotherapy alone (18.2 months vs 12 months; hazard ratio [HR] 0.62, 95% CI, 0.52-0.75; P<.0001).
Reduced interest seen in minority and less educated populations.
Mirvetuximuab soravtansine uses a humanized FRα-binding antibody to target antibody-drug conjugates specifically to FRα-expressing cancer cells and a potent anti-tumor agent, DM4, to kill the targeted cancer cells.
Standardized definition, guidance on estimation may facilitate understanding of overdiagnosis.
Social media is an ideal platform to reach teenagers and young adults to encourage sun safety.
Investigators report results from the MONALEESA-7 trial, which assessed ribociclib plus endocrine therapy in premenopausal women with advanced breast cancer.
Greater reproducibility and higher concordance for melanoma staging with implementation of AJCC 8
The percentage of NPs who order the mt-sDNA test for colorectal cancer screening has increased significantly since the test became available in 2014.
Percutaneous ablation compared with partial, radical nephrectomy for 4,310 patients aged 66 years
Vivio can accurately detect cardiac dysfunction in anthracycline-exposed childhood cancer survivors
In women, risk declines as levels increase up to 100 nmol/L, but association in men not significant
Regardless of age, favorable survival conferred by an HPV-positive tumor status
From 2006 and 2016, smallest increase seen in high Sociodemographic Index countries.
Increased risk of subsequent diabetes independent of traditional diabetes risk factors
A smartphone application is a more effective learning tool for accurately diagnosing melanoma compared with traditional, rule-based methods.
A prophylactic, graded, extended infusion of carboplatin, compared with a shorter, standard infusion, is not associated with a reduced rate of HSRs in women with recurrent ovarian cancer.
Cryoablation also cuts the need for opioids at 24 hours post-treatment and at three months
Lyme neuroborreliosis diagnosis had no substantial effect on long-term survival, health, or educational/social functioning yet may be associated with an increased risk of hematologic and nonmelanoma skin cancers.
Alternative sun protection products, including pills and dietary supplements, are misleading consumers through false marketing and advertising.
In year 1, 13% did not undergo MRI or mammography; up to 19% by year 5.
Average-risk adults aged 45 should undergo high-sensitivity stool-based test, structural exam
In a case study, olaparib was found to induce folate deficiency in most patients with relapsed ovarian cancer. Researchers discuss the significance of this adverse effect and how it was managed.
Age at diagnosis, sex, BMI, and thyroid-stimulating hormone suppression therapy affect CVD risk
The American College of Cardiology, along with several other cardiology societies, have updated guidelines on best practices for improving safety when using ionizing radiation during cardiovascular imaging.
Findings for men with intermediate- and high-risk prostate cancer
Crossover in sex-specific rates among US non-Hispanic whites born since 1965
Grip strength is strongly and inversely associated with all-cause mortality and incidence of and mortality from cardiovascular disease, respiratory disease, COPD, all cancer, and subtypes of cancer, with associations being modestly stronger in the younger age groups.
Risk not increased for non-advanced adenoma found on colonoscopy following flex sigmoidoscopy
AAPA and SDPA respond to a recent article published in JAMA Dermatology.
But majority of oncologists don't feel knowledgeable enough to make these recommendations