Hematology/Oncology News Archive

RSNA: Mammography May Benefit 30-Year-Olds With Risk Factors

Early screening may benefit those with dense breasts, personal/family history of breast cancer.

Ovarian Cancer Risk Linked to Ultrasonographic Characteristics of Ovarian Masses

Pelvic ultrasonography was used to distinguish between simple cysts and more complex cysts or solid masses, which are associated with an increased risk of ovarian cancer.

2018 World Conference on Lung Cancer: 8 Key Findings

In September, health experts from around the globe gathered at the 2018 World Conference on Lung Cancer in Toronto. We compiled a list of 8 key findings presented at the event.

RSNA: Mammography Has Value in Women Age 75 or Older

Cancer detection rate is 8.4/1000 exams in older women; 98% of cancers surgically excised.

Checkpoint Inhibitor Pneumonitis in NSCLC

Immune checkpoint inhibitor pneumonitis is a potentially serious complication that may occur more in patients with lung cancer than previously suspected.

Obesity as a Teen Ups Risk for Later Pancreatic Cancer

In men, overweight and even higher normal weight tied to increased risk.

Keytruda Gets FDA Approval for Hepatocellular Carcinoma

The approval was based on data from the KEYNOTE-224 study, a single-arm trial in patients with HCC who had disease progression on or after sorafenib or were intolerant to sorafenib; had measurable disease; and Child-Pugh class A liver impairment.

Heart Disease Leading Cause of Death in Low-Income Counties

Greatest shift to cancer as leading cause of death seen in highest-income counties in United States.

AHA: Limited Benefit for n-3 Fatty Acids in CVD, Cancer Prevention

Second study shows no significant results for vitamin D supplementation vs placebo.

Coordinated Care Needed for Cancer Survivors, Caregivers

Efforts needed in implementing routine assessments of needs, facilitating personalized referrals.

Many Women Have Not Heard of Ovarian Cancer Before Diagnosis

Nine in 10 women experience multiple symptoms prediagnosis; 8 in 10 of them consult a doctor.

Higher Sensitivity With 1-View Digital Breast Tomosynthesis for Breast Cancer Detection

One-view digital breast tomosynthesis with a reduced compression force detected breast cancer with higher sensitivity and lower specificity than 2-view digital mammography.

Models Project 79% Drop in Lung CA Mortality by 2065

Annual number of deaths expected to continue to decrease despite growth, aging of US population.

Angiotensin-Converting Enzyme Inhibitors May Increase Lung Cancer Risk

The use of angiotensin-converting enzyme inhibitors is associated with an increased risk for lung cancer compared with angiotensin receptor blockers.

HPV Screening Associated With Reduced Remaining Lifetime Cervical Cancer Risk in Older Women

Researchers determined that women ≥55 years of age who underwent a single HPV DNA test with a negative diagnosis as well as routine cytology were found to be at low risk for cervical cancer.

Barriers to Prostate Cancer Research in Black Men Identified

A lack of understanding of terminology, health care system distrust, and a lack of prostate cancer knowledge are among the barriers to genomic testing for prostate cancer and prostate cancer research participation among black men.

AAD Releases New Guidelines for the Treatment of Cutaneous Melanoma

New guidelines have been released for the treatment of primary cutaneous melanoma, according to a report from the American Academy of Dermatology.

Screening for Ovarian Cancer in Low-Risk Women Influenced by Clinician Personal Experience

Nonprofessional experience with cancer may be associated with a lack of adherence to ovarian cancer screening guidelines.

New Method Estimates Risk for Recurrence in Breast Cancer

The risk for breast cancer recurrence can be extracted using disease-specific survival data.

Open Surgery for Early Lung Cancer Tied to Long-Term Opioid Use

Surgical invasiveness might play a role in the odds of becoming a long-term opioid user after early-stage lung cancer surgery.

Tobacco Use Remains Leading Modifiable Cause of Cancer

Tobacco use remains the leading modifiable cause of cancer and should be a priority for cancer control.

AF Patients With Cancer Less Likely to See Cardiologist

Those who do see a cardiologist are more likely to fill anticoagulant prescription and have reduced risk for stroke.

Chemotherapy Plays a Role in Skeletal Muscle Atrophy in Patients With Breast Cancer

Treatment with chemotherapeutics promoted atrophy and mitochondrial damage in breast muscle cells.

Chemoimmunotherapy Increases Survival in Triple-Negative Breast Cancer

For patients with metastatic triple-negative breast cancer, atezolizumab plus nanoparticle albumin-bound-paclitaxel prolongs progression-free survival compared with placebo plus nab-paclitaxel.

Organic Food Consumption and Cancer Risk: What's the Link?

To investigate the link between organic food consumption and cancer risk, study authors conducted a population-based prospective cohort study among French adults.

Real-World Experience Differs from Trial Results for Niraparib in Recurrent Ovarian Cancer

Patients in the real world setting were initiated at a lower dose and experienced fewer side effects than trial participants.

Talzenna Approved for Germline BRCA-Mutated, HER2-Negative Breast Cancer

Talzenna, a poly (ADP-ribose) polymerase (PARP) inhibitor, was evaluated in EMBRACA, an open-label trial that randomized patients with gBRCAm HER2-negative locally advanced or metastatic breast cancer (N=431) to receive talazoparib 1mg or physician's choice of chemotherapy (capecitabine, eribulin, gemcitabine, or vinorelbine).

Weight Loss May Reduce Breast Cancer Risk in Postmenopausal Women

Postmenopausal women with weight loss have a reduced risk for breast cancer.

Higher Levels of Anti-CA15.3 and Anti-CA125 Linked to Increased Risk for Mucinous Epithelial Ovarian Cancer

Researchers used the EPIC Cohort to identify whether anti-CA125 and anti-CA15.3 antibodies alone or in combination with antigens may determine epithelial ovarian cancer risk.

Better Efforts Needed for Cancer Patients With Pessimistic Illness Perceptions

Among cancer survivors, illness perception may affect patient health-related quality of life and mortality.

Ovarian Cancer Risk Reduced With Regular, Low-Dose Aspirin

Although ovarian cancer risk may be reduced with regular use of low-dose aspirin, the use of nonaspirin analgesics may increase the risk of ovarian cancer among long-term, high-quantity users.

FDA Amends Food Additive Regulations to No Longer Allow Use of 7 Substances

The petition was submitted by a number of non-profit organizations including the Center for Science in the Public Interest and the Breast Cancer Fund.

Weight Loss May Predict Cancer Diagnosis in Primary Care

Weight loss may indicate a cancer diagnosis in patients presenting in primary care, specifically when weight loss correlates to another cancer-related clinical feature.

Genomic Screening Can ID Undetected BRCA1/2 Cancer Risk

82 percent of variant carriers identified in exome sequencing had not undergone prior testing.

Ketogenic Diet May Benefit Ovarian, Endometrial Cancer Patients

Women with ovarian or endometrial cancer who adhere to a ketogenic diet may benefit from a selective loss of fat mass and a reduction in fasting serum insulin, while still retaining lean mass.

Second Opinion at NCI Center Valuable for Breast CA Patients

Almost 43% of those presenting to NCI center for second opinion have change in diagnosis.

Risk of Venous Thromboembolism Recurrence High

At 6 months, rates for provoked, unprovoked, cancer-related VTE are 6.8, 6.92, 9.06 per 100 person-years.

Barriers Found in PCP Knowledge of Surveillance of Hepatocellular Carcinoma

Barriers found among PCPs in surveillance of HCC indicate the need for clinical interventions, including provider education.

Talazoparib Shows Antitumor Activity in Advanced Breast Cancer, Germline BRCA Mutation

Talazoparib, a poly(adenosine diphosphate-ribose) inhibitor, may significantly enhance progression-free survival in patients with advanced breast cancer and a germline BRCA1/2 mutation.

Newer Hormonal Contraception May Cut Ovarian Cancer Risk

Combined hormonal contraception use tied to lower risk; risk down with increasing duration of use.

Ribociclib FDA-Approved For Additional Indications in HR+, HER2- Advanced Breast Cancer

The FDA based its approval on the results of a triplet of phase 3 studies, the MONALEESA-2, MONALEESA-3, and MONALEESA-7.

Tucatinib May Be A Safe, Novel Treatment for ERBB2/HER2-Positive Breast Cancer

For this phase 1b study, researchers enrolled 57 patients with ERBB2/HER2-positive metastatic breast cancer previously treated with trastuzumab and a taxane.

NAMS: Breast Cancer Diagnosis May Indicate Lower Vitamin D Levels, Obesity in Postmenopausal Women

The North American Menopause Society has found that postmenopausal women with a breast cancer diagnosis may have vitamin D deficiency as well as higher rates of obesity.

Beyond BRCA: New Predisposition Genes Linked to Breast, Ovarian Cancers

Whole-exome sequencing revealed that PALB2, ATM, CHEK2, and MSH6 genes were significantly associated with an increased risk of breast cancer; MSH6, RAD51C, TP53, and ATM were found to be linked to an increased risk of ovarian cancer.

Olaparib Treatment May Improve Health-Related Quality of Life in Germline BRCA1/2-Mutated Ovarian Cancer

Olaparib, may help to improve duration of good quality of life and quality-adjusted progression-free survival in germline BRCA1/2-mutated ovarian cancer.

PSA Testing Not Recommended for Prostate Cancer Screening

Odds of choosing screening up for men with family history, African descent, low socioeconomic status.

Poor, Non-English Speaking Cancer Patients Need Support

Serving patients' specific needs, such as referral to socioeconomic support, can improve care.

Computer-Aided Colonoscopy Reliably Identifies Small Polyps

Diagnosing, but leaving these polyps can save time and, likely, costs.

TNFi Not Linked to Increased Cancer Recurrence in RA Patients

No increased risk of cancer recurrence among RA patients initiating tumor necrosis factor inhibitor treatment.

Similar Outcomes for Rural, Urban Cancer Patients in SWOG Trials

Few differences between rural, urban patients in cancer outcomes with uniform access to cancer care.

USPSTF Updates Guidance for Cervical Cancer Screening

Cytology recommended every 3 years from age 21; different screening options from age 30 to 65.

Investigational Therapy Gets Fast Track Status for Recurrent Ovarian Cancer

A Phase 1 study in healthy volunteers showed a favorable safety profile with no serious adverse events.

Lumpectomy + Radiation May Cut Breast Cancer Mortality in DCIS

Lumpectomy, radiotherapy tied to reduction in breast cancer mortality vs lumpectomy, mastectomy.

Cancer Patients Treated With Step III Opioids Often Have Sleep Disturbances

The majority of patients with cancer who are being treated with World Health Organization Step III opioids were found to experience poor sleep quality, often due to pain.

Majority of Patients With Liver Metastases From Colorectal Cancer Eligible for Laparoscopy

In high-volume centers, patients with liver metastases from colorectal cancer may often be eligible for minimally invasive liver surgery via laparoscopy, thereby reducing potential morbidity risks associated with open surgery.

Copy Number Abnormalities May Inform Survival, Drug Resistance

For cancers associated with numerous copy number changes, it is difficult to assign disease classifiers and identify useful targets for drug development.

Dermatologist Intervention Tied to Better Sun Protection

Short intervention associated with more sunscreen use, improved patient satisfaction.

Proton Pump Inhibitor Treatment and Aspirin Improve Outcomes in Barrett Esophagus

High-dose esomeprazole taken in combination with aspirin may safely and effectively improve outcomes in patients with Barrett esophagus.

TGFB1 Mutation Ups Radiation-Induced Breast Fibrosis Risk

C-509T allele and postoperative cosmetic surgery significantly linked to breast fibrosis risk.

Higher Risk of In Situ Breast CA, Ovarian Tumors With Fertility Treatment

No increased risk of corpus uteri, invasive breast cancer for women undergoing assisted reproduction.

Link for Asbestos-Free Talcum Powder, Cancer Not Clear

Studies conducted in people have mixed results, with some indication of increased risk of ovarian cancer.

HPV Vaccine Eliminates Advanced Skin Cancer in 97-Year-Old

Less than a year following the initial direct-to-tumor vaccine injection, all treated tumors disappeared.

FDA Grants First Approval for CA Drug Under New Pilot Programs

Ribociclib approved in combo with AI as endocrine tx for HR-positive, HER2-negative advanced breast CA.

Australian Researchers Develop First Blood Test for Melanoma

10 autoantibody biomarkers together display high sensitivity, specificity.

Skin Cancer Education May Improve Sun Protection Practices Among Organ Transplant Recipients

The use of multiple sun protection measures was defined as the use of 2 or more of these measures more than 50% of the time when the individual was outdoors.

Risk of CRC, Non-CRC Death Increases With Positive Fecal Hemoglobin Test

Positive guaiac fecal occult blood test result linked to increased risk of death from circulatory, respiratory, other diseases.

Guidelines for Management of Hypothalamic-Pituitary, Growth Disorders in Childhood Cancer Survivors

The Endocrine Society, European Society of Endocrinology, and Pediatric Endocrine Society issue guidelines for the management of hypothalamic-pituitary and growth disorders in childhood cancer survivors.

Chemotherapy With Bevacizumab May Improve Some Ovarian Cancer Outcomes, Worsen Others

First-line chemotherapy in combination with bevacizumab, compared with chemotherapy alone, may benefit patients with ovarian cancer and elevated neutrophil-to-lymphocyte ratios.

Progress Report in Cancer Control: How Are We Doing?

An analysis of population data on cancer incidence, survival, and mortality revealed that early interventions and improvements to treatments contributed to a 26% decline in cancer deaths from 1991 to 2015.

No Difference in CEA vs CA125/CEA Ratio for Identifying Ovarian Masses

No significant difference was identified in combination CA125/CEA ratio vs CEA alone in distinguishing ovarian neoplasms from ovarian metastases.

Avastin Plus ChemoTx Approved for Advanced Ovarian Cancer After Resection

Study patients who received Avastin plus chemotherapy followed by Avastin alone, had a greater median PFS vs patients who received chemotherapy alone (18.2 months vs 12 months; hazard ratio [HR] 0.62, 95% CI, 0.52-0.75; P<.0001).

Patient Interest Fairly High for Melanoma Genetic Risk Testing

Reduced interest seen in minority and less educated populations.

Mirvetuximab Gets Fast Track Status for Platinum-Resistant Ovarian Cancer

Mirvetuximuab soravtansine uses a humanized FRα-binding antibody to target antibody-drug conjugates specifically to FRα-expressing cancer cells and a potent anti-tumor agent, DM4, to kill the targeted cancer cells.

Authors Explore Overdiagnosis in Cancer Screening

Standardized definition, guidance on estimation may facilitate understanding of overdiagnosis.

#DontFryDay: 12 Million Twitter Impressions Spread Message of Sun Safety

Social media is an ideal platform to reach teenagers and young adults to encourage sun safety.

Ribociclib Prolongs Progression-Free Survival in Premenopausal Breast Cancer

Investigators report results from the MONALEESA-7 trial, which assessed ribociclib plus endocrine therapy in premenopausal women with advanced breast cancer.

New Guidelines Increase Melanoma Staging Reproducibility

Greater reproducibility and higher concordance for melanoma staging with implementation of AJCC 8

More NPs Ordering Multitarget Stool DNA Test for Colorectal Cancer Screening

The percentage of NPs who order the mt-sDNA test for colorectal cancer screening has increased significantly since the test became available in 2014.

Study Compares Treatment Options for T1a Renal Cancer

Percutaneous ablation compared with partial, radical nephrectomy for 4,310 patients aged 66 years

Handheld Device Can ID Cardiac Dysfunction in Cancer Survivors

Vivio can accurately detect cardiac dysfunction in anthracycline-exposed childhood cancer survivors

Higher Vitamin D Levels Tied to Lower Risk of Colorectal Cancer

In women, risk declines as levels increase up to 100 nmol/L, but association in men not significant

Older Adults Increasingly Have HPV+ Oropharyngeal Cancers

Regardless of age, favorable survival conferred by an HPV-positive tumor status

Increase in Global Cancer Incidence, Drop in Death Rates

From 2006 and 2016, smallest increase seen in high Sociodemographic Index countries.

Cancer Development Linked to Increased Diabetes Risk

Increased risk of subsequent diabetes independent of traditional diabetes risk factors

Smartphone App Effectively Teaches Visual Diagnosis of Melanoma

A smartphone application is a more effective learning tool for accurately diagnosing melanoma compared with traditional, rule-based methods.

Prophylactic, Extended Carboplatin Infusion Not Linked to Lower HSR in Ovarian Cancer Patients

A prophylactic, graded, extended infusion of carboplatin, compared with a shorter, standard infusion, is not associated with a reduced rate of HSRs in women with recurrent ovarian cancer.

Cryoablation Efficacious for Cancer Pain, Review Finds

Cryoablation also cuts the need for opioids at 24 hours post-treatment and at three months

Lyme Neuroborreliosis: Long-Term Survival and Health Outcomes

Lyme neuroborreliosis diagnosis had no substantial effect on long-term survival, health, or educational/social functioning yet may be associated with an increased risk of hematologic and nonmelanoma skin cancers.

FDA Warns Companies Promoting Ineffective "Sunscreen Pills"

Alternative sun protection products, including pills and dietary supplements, are misleading consumers through false marketing and advertising.

Many Breast Cancer Survivors Do Not Undergo Annual Surveillance

In year 1, 13% did not undergo MRI or mammography; up to 19% by year 5.

ACS Updates Colorectal Cancer Screening to Start at Age 45

Average-risk adults aged 45 should undergo high-sensitivity stool-based test, structural exam

Severe Folate Deficiency Associated With Olaparib for Relapsed Ovarian Cancer

In a case study, olaparib was found to induce folate deficiency in most patients with relapsed ovarian cancer. Researchers discuss the significance of this adverse effect and how it was managed.

Male Thyroid Cancer Survivors Face Higher CVD Risk

Age at diagnosis, sex, BMI, and thyroid-stimulating hormone suppression therapy affect CVD risk

ACC Outlines Best Practices for Ionizing Radiation Use in Cardiovascular Imaging

The American College of Cardiology, along with several other cardiology societies, have updated guidelines on best practices for improving safety when using ionizing radiation during cardiovascular imaging.

PSA Level 3 Months After Radiation Treatment May Predict Outcome

Findings for men with intermediate- and high-risk prostate cancer

Lung Cancer Incidence Higher for Young Women Than Young Men

Crossover in sex-specific rates among US non-Hispanic whites born since 1965

Hand Grip Strength Associated With All-Cause Mortality, Other Adverse Outcomes

Grip strength is strongly and inversely associated with all-cause mortality and incidence of and mortality from cardiovascular disease, respiratory disease, COPD, all cancer, and subtypes of cancer, with associations being modestly stronger in the younger age groups.

Higher CRC Risk With Advanced Adenoma Found on Colonoscopy

Risk not increased for non-advanced adenoma found on colonoscopy following flex sigmoidoscopy

AAPA Responds to JAMA Dermatology Study

AAPA and SDPA respond to a recent article published in JAMA Dermatology.

Many Oncologists Discuss, Recommend Medical Marijuana

But majority of oncologists don't feel knowledgeable enough to make these recommendations

Sign Up for Free e-newsletters