Hematology/Oncology News Archive

Computer-Aided Colonoscopy Reliably Identifies Small Polyps

Diagnosing, but leaving these polyps can save time and, likely, costs.

TNFi Not Linked to Increased Cancer Recurrence in RA Patients

No increased risk of cancer recurrence among RA patients initiating tumor necrosis factor inhibitor treatment.

Similar Outcomes for Rural, Urban Cancer Patients in SWOG Trials

Few differences between rural, urban patients in cancer outcomes with uniform access to cancer care.

USPSTF Updates Guidance for Cervical Cancer Screening

Cytology recommended every 3 years from age 21; different screening options from age 30 to 65.

Investigational Therapy Gets Fast Track Status for Recurrent Ovarian Cancer

A Phase 1 study in healthy volunteers showed a favorable safety profile with no serious adverse events.

Lumpectomy + Radiation May Cut Breast Cancer Mortality in DCIS

Lumpectomy, radiotherapy tied to reduction in breast cancer mortality vs lumpectomy, mastectomy.

Cancer Patients Treated With Step III Opioids Often Have Sleep Disturbances

The majority of patients with cancer who are being treated with World Health Organization Step III opioids were found to experience poor sleep quality, often due to pain.

Majority of Patients With Liver Metastases From Colorectal Cancer Eligible for Laparoscopy

In high-volume centers, patients with liver metastases from colorectal cancer may often be eligible for minimally invasive liver surgery via laparoscopy, thereby reducing potential morbidity risks associated with open surgery.

Copy Number Abnormalities May Inform Survival, Drug Resistance

For cancers associated with numerous copy number changes, it is difficult to assign disease classifiers and identify useful targets for drug development.

Dermatologist Intervention Tied to Better Sun Protection

Short intervention associated with more sunscreen use, improved patient satisfaction.

Proton Pump Inhibitor Treatment and Aspirin Improve Outcomes in Barrett Esophagus

High-dose esomeprazole taken in combination with aspirin may safely and effectively improve outcomes in patients with Barrett esophagus.

TGFB1 Mutation Ups Radiation-Induced Breast Fibrosis Risk

C-509T allele and postoperative cosmetic surgery significantly linked to breast fibrosis risk.

Higher Risk of In Situ Breast CA, Ovarian Tumors With Fertility Treatment

No increased risk of corpus uteri, invasive breast cancer for women undergoing assisted reproduction.

Link for Asbestos-Free Talcum Powder, Cancer Not Clear

Studies conducted in people have mixed results, with some indication of increased risk of ovarian cancer.

HPV Vaccine Eliminates Advanced Skin Cancer in 97-Year-Old

Less than a year following the initial direct-to-tumor vaccine injection, all treated tumors disappeared.

FDA Grants First Approval for CA Drug Under New Pilot Programs

Ribociclib approved in combo with AI as endocrine tx for HR-positive, HER2-negative advanced breast CA.

Australian Researchers Develop First Blood Test for Melanoma

10 autoantibody biomarkers together display high sensitivity, specificity.

Skin Cancer Education May Improve Sun Protection Practices Among Organ Transplant Recipients

The use of multiple sun protection measures was defined as the use of 2 or more of these measures more than 50% of the time when the individual was outdoors.

Risk of CRC, Non-CRC Death Increases With Positive Fecal Hemoglobin Test

Positive guaiac fecal occult blood test result linked to increased risk of death from circulatory, respiratory, other diseases.

Guidelines for Management of Hypothalamic-Pituitary, Growth Disorders in Childhood Cancer Survivors

The Endocrine Society, European Society of Endocrinology, and Pediatric Endocrine Society issue guidelines for the management of hypothalamic-pituitary and growth disorders in childhood cancer survivors.

Chemotherapy With Bevacizumab May Improve Some Ovarian Cancer Outcomes, Worsen Others

First-line chemotherapy in combination with bevacizumab, compared with chemotherapy alone, may benefit patients with ovarian cancer and elevated neutrophil-to-lymphocyte ratios.

Progress Report in Cancer Control: How Are We Doing?

An analysis of population data on cancer incidence, survival, and mortality revealed that early interventions and improvements to treatments contributed to a 26% decline in cancer deaths from 1991 to 2015.

No Difference in CEA vs CA125/CEA Ratio for Identifying Ovarian Masses

No significant difference was identified in combination CA125/CEA ratio vs CEA alone in distinguishing ovarian neoplasms from ovarian metastases.

Avastin Plus ChemoTx Approved for Advanced Ovarian Cancer After Resection

Study patients who received Avastin plus chemotherapy followed by Avastin alone, had a greater median PFS vs patients who received chemotherapy alone (18.2 months vs 12 months; hazard ratio [HR] 0.62, 95% CI, 0.52-0.75; P<.0001).

Patient Interest Fairly High for Melanoma Genetic Risk Testing

Reduced interest seen in minority and less educated populations.

Mirvetuximab Gets Fast Track Status for Platinum-Resistant Ovarian Cancer

Mirvetuximuab soravtansine uses a humanized FRα-binding antibody to target antibody-drug conjugates specifically to FRα-expressing cancer cells and a potent anti-tumor agent, DM4, to kill the targeted cancer cells.

Authors Explore Overdiagnosis in Cancer Screening

Standardized definition, guidance on estimation may facilitate understanding of overdiagnosis.

#DontFryDay: 12 Million Twitter Impressions Spread Message of Sun Safety

Social media is an ideal platform to reach teenagers and young adults to encourage sun safety.

Ribociclib Prolongs Progression-Free Survival in Premenopausal Breast Cancer

Investigators report results from the MONALEESA-7 trial, which assessed ribociclib plus endocrine therapy in premenopausal women with advanced breast cancer.

New Guidelines Increase Melanoma Staging Reproducibility

Greater reproducibility and higher concordance for melanoma staging with implementation of AJCC 8

More NPs Ordering Multitarget Stool DNA Test for Colorectal Cancer Screening

The percentage of NPs who order the mt-sDNA test for colorectal cancer screening has increased significantly since the test became available in 2014.

Study Compares Treatment Options for T1a Renal Cancer

Percutaneous ablation compared with partial, radical nephrectomy for 4,310 patients aged 66 years

Handheld Device Can ID Cardiac Dysfunction in Cancer Survivors

Vivio can accurately detect cardiac dysfunction in anthracycline-exposed childhood cancer survivors

Higher Vitamin D Levels Tied to Lower Risk of Colorectal Cancer

In women, risk declines as levels increase up to 100 nmol/L, but association in men not significant

Older Adults Increasingly Have HPV+ Oropharyngeal Cancers

Regardless of age, favorable survival conferred by an HPV-positive tumor status

Increase in Global Cancer Incidence, Drop in Death Rates

From 2006 and 2016, smallest increase seen in high Sociodemographic Index countries.

Cancer Development Linked to Increased Diabetes Risk

Increased risk of subsequent diabetes independent of traditional diabetes risk factors

Smartphone App Effectively Teaches Visual Diagnosis of Melanoma

A smartphone application is a more effective learning tool for accurately diagnosing melanoma compared with traditional, rule-based methods.

Prophylactic, Extended Carboplatin Infusion Not Linked to Lower HSR in Ovarian Cancer Patients

A prophylactic, graded, extended infusion of carboplatin, compared with a shorter, standard infusion, is not associated with a reduced rate of HSRs in women with recurrent ovarian cancer.

Cryoablation Efficacious for Cancer Pain, Review Finds

Cryoablation also cuts the need for opioids at 24 hours post-treatment and at three months

Lyme Neuroborreliosis: Long-Term Survival and Health Outcomes

Lyme neuroborreliosis diagnosis had no substantial effect on long-term survival, health, or educational/social functioning yet may be associated with an increased risk of hematologic and nonmelanoma skin cancers.

FDA Warns Companies Promoting Ineffective "Sunscreen Pills"

Alternative sun protection products, including pills and dietary supplements, are misleading consumers through false marketing and advertising.

Many Breast Cancer Survivors Do Not Undergo Annual Surveillance

In year 1, 13% did not undergo MRI or mammography; up to 19% by year 5.

ACS Updates Colorectal Cancer Screening to Start at Age 45

Average-risk adults aged 45 should undergo high-sensitivity stool-based test, structural exam

Severe Folate Deficiency Associated With Olaparib for Relapsed Ovarian Cancer

In a case study, olaparib was found to induce folate deficiency in most patients with relapsed ovarian cancer. Researchers discuss the significance of this adverse effect and how it was managed.

Male Thyroid Cancer Survivors Face Higher CVD Risk

Age at diagnosis, sex, BMI, and thyroid-stimulating hormone suppression therapy affect CVD risk

ACC Outlines Best Practices for Ionizing Radiation Use in Cardiovascular Imaging

The American College of Cardiology, along with several other cardiology societies, have updated guidelines on best practices for improving safety when using ionizing radiation during cardiovascular imaging.

PSA Level 3 Months After Radiation Treatment May Predict Outcome

Findings for men with intermediate- and high-risk prostate cancer

Lung Cancer Incidence Higher for Young Women Than Young Men

Crossover in sex-specific rates among US non-Hispanic whites born since 1965

Hand Grip Strength Associated With All-Cause Mortality, Other Adverse Outcomes

Grip strength is strongly and inversely associated with all-cause mortality and incidence of and mortality from cardiovascular disease, respiratory disease, COPD, all cancer, and subtypes of cancer, with associations being modestly stronger in the younger age groups.

Higher CRC Risk With Advanced Adenoma Found on Colonoscopy

Risk not increased for non-advanced adenoma found on colonoscopy following flex sigmoidoscopy

AAPA Responds to JAMA Dermatology Study

AAPA and SDPA respond to a recent article published in JAMA Dermatology.

Many Oncologists Discuss, Recommend Medical Marijuana

But majority of oncologists don't feel knowledgeable enough to make these recommendations

Ovarian Cancer Patients May Benefit From Trabectedin With PLD

For patients with platinum-sensitive recurrent ovarian cancer, trabectedin plus PLD may be beneficial.

Highly Selective, First-in-Class CDK4 Inhibitor Promising in Ovarian Cancer

Mice treated with 2-94 had few or no signs of lymphopenia or neutropenia, common adverse events associated with palbociclib.

Personalized Cancer Vaccine Looks Promising in Early Study

The researchers enrolled 25 platinum-pretreated, immunotherapy-naïve patients with recurrent advanced epithelial ovarian cancer (EOC) for the trial.

FDA Targets Clinics Offering Unapproved Stem Cell Therapies

Clinics claim unapproved therapies can treat number of diseases and conditions, including ALS and cancer

Chronic Aspirin Exposure Linked to Melanoma Risk in Males

Significantly increased risk of malignant melanoma in males, but not females, on once-daily aspirin

PAs Have Lower Diagnostic Accuracy for Melanoma Compared With Dermatologists

Compared with dermatologists, physician assistants perform more skin biopsies but detect fewer melanomas.

Long-Term Cardiovascular Risk for Endometrial Cancer Survivors

Elevated risk of various cardiovascular outcomes, including pulmonary heart disease, atrial fibrillation

Screening for Prostate Cancer: USPSTF Recommendation Statement

The USPSTF has updated its 2012 recommendations on prostate-specific antigen (PSA)-based screening for prostate cancer.

Intrathecal Drug Delivery and Spinal Cord Stimulation for Cancer Pain: A Review

Intrathecal drug delivery systems and spinal cord stimulation have shown promise for the treatment of cancer pain in initial studies.

Flexible Sigmoidoscopy Cuts CRC Incidence, Mortality in Men

Absolute risks for colorectal cancer, CRC death not reduced for screening group vs controls in women

Adjuvant Pembrolizumab Beneficial in Stage III Melanoma

Pembrolizumab linked to significantly longer recurrence-free survival at 15-month follow-up

Advanced Ovarian Cancer Survival Rates Longer After Primary Cytoreductive Surgery Compared With Neoadjuvant Chemotherapy

Researchers found a superior survival rate in patients who received primary cytoreductive surgery as opposed to neoadjuvant chemotherapy for stage IIIC and IV high-grade serous ovarian carcinoma.

FDA Approves Multi-Cancer Treatment Drug

The FDA has approved Rubraca, a poly (ADP-ribose) polymerase inhibitor, to treat patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer.

Pap Tests May Help Diagnose Endometrial, Ovarian Cancers

Genetic mutations assays using PapSEEK may facilitate the detection of certain cancers using fluids from Pap tests.

Vigil Immunotherapy and PARP 7 Treatments for Patients with Ovarian Cancer

Vigil immunotherapy is possible for women with recurrent ovarian cancer and PARP 7 may impact ovarian cancer survival, according to two studies presented in New Orleans.

Prostate-specific antigen screening helps prostate cancer detection

Prostate cancer was diagnosed more frequently in men who underwent single prostate-specific antigen screening than in those who did not, but mortality was unaffected.

Behavioral Counseling for Skin Cancer Prevention: USPSTF Updated Recommendations

The USPSTF has updated both the 2012 recommendation on behavioral counseling for the primary prevention of skin cancer and the 2009 recommendation on screening for skin cancer with skin self-examination.

NCCN's anticancer drug recommendations beyond FDA approval based on weak evidence

Does weak evidence drive the NCCN recommendations of FDA-approved drugs?

Gap identified in colorectal cancer screening among low-income populations

Improving colorectal cancer screening rates among lower-income populations requires addressing structural, personal, and health care system barriers.

Colorectal cancer screening doubled with use of a digital health program

The use of the Mobile Patient Technology for Health-CRC (mPATH-CRC) digital health program doubles the proportion of patients who completed colorectal cancer (CRC) screening.

Colorectal cancer risk in veterans significantly reduced with colonoscopy screening

Colonoscopy is associated with significant reductions in colorectal cancer mortality among veterans and with greater benefit for left-sided cancer than right-sided cancer.

High vitamin D concentration associated with lower cancer risk

A higher concentration of plasma vitamin D is correlated with a decreased risk of total cancer.

Aggressive treatment not beneficial for metastatic prostate cancer

For men with metastatic prostate cancer, aggressive therapy has no significant advantage over conservative androgen deprivation only treatments.

Cooling therapy for hand-foot syndrome prevention, management

For patients with ovarian cancer taking pegylated liposomal doxorubicin who have hand-foot syndrome, frozen gloves and socks is a safe method of treatment.

Ovarian cancer may be paternally inherited

The disease allele may be passed from affected grandmother to granddaughter through the father's inherited genes.

Cancer history affects mortality risk independent of CV risk

Cancer history has an important impact on mortality independent of cardiovascular risk factors.

Ultra-processed foods may increase overall, breast cancer risks

An increased consumption of processed foods by 10% was associated with more than 10% increased risk for overall and breast cancers.

Ovarian cancer risk reduced with oral contraceptives

The use of oral contraceptives did not reduce the risks of breast cancer or colorectal cancer.

Ovarian cancer screening: updated recommendations from the USPSTF

The USPSTF has issued an updated recommendation statement on ovarian cancer screening.

Primary gastrinomas of the hepatobiliary tract may occur in patients with Zollinger-Ellison syndrome

Lymph nodes proximal to hepatic or biliary gastrinomas will likely require extraction as many in the surround region will have metastasized.

Assessing the impact of antidepressants on ovarian cancer risk

Past epidemiological investigations resulted in inconsistent reports on the affiliation between antidepressants and the risk of ovarian cancer.

Ovarian cancer patients may benefit from added hyperthermic intraperitoneal chemotherapy

The addition of HIPEC resulted in longer recurrence-free and overall survival among patients with ovarian cancer.

Prostate cancer recurrence linked to metabolic syndrome, obesity

A positive correlation between increased BMI and risk of prostate cancer recurrence was observed in patients undergoing radical prostatectomy.

Guidelines for basal, cutaneous squamous cell carcinoma management

Guidelines were provided for basal cell carcinoma and cutaneous squamous cell carcinoma.

Depressive symptoms may predict mortality in head, neck cancer

Depressive symptoms at the time of treatment planning can predict overall 2 year mortality in patients with head and neck cancer.

Clinical tool may help in prostate cancer screenings

Polygenic hazard scores were developed to help predict the age of onset of prostate cancer.

Multi-analyte blood test detects 8 common cancers

A multi-analyte blood test, CancerSEEK, can detect 8 common cancer types, with high sensitivity and specificity.

BRCA might not affect young-onset breast cancer survival rates

Both patients with and without BRCA mutations have comparable survival rates.

Cancer risk in women who work night shifts long-term

For women who work night shifts, breast cancer risks increase by 3.3% for every 5 years of work.

Skin cancer risk higher in patients with atopic dermatitis

Patients with atopic dermatitis may have a greater risk of developing squamous cell carcinoma.

Hormonal contraception use linked to an increased risk of breast cancer

Breast cancer diagnosis is higher among women who currently use or recently used contemporary hormonal contraceptives than among women who have never used hormonal contraceptives.

Nivolumab treatment for lung cancer may successfully deplete HIV reservoirs

Nivolumab treatment for non-small-cell lung cancer may induce successful depletion of HIV reservoir.

Adolescent acne not linked to malignant melanoma in men

Body mass index is linked to malignant melanoma in men.

Oxybenzone in lotion linked to dermatological, environmental toxicity

Oxybenzone, found in sunscreens and other products, has harmful dermatological and environmental effects.

FDA approves new hemophilia A drug with factor VIII inhibitors

New FDA-approved prophylactic treatment decreases bleeding episodes hemophilia A patients with factor VIII inhibitors.

ASCO: Alcohol consumption increases cancer risk

According to a special report by the American Society of Clinical Oncology, alcohol consumption is a definite risk for cancer development.

Overweight, obesity-related cancers increasing in the United States

Incidence rates of overweight- and obesity-related cancers have increased in the United States.

Sign Up for Free e-newsletters