Hepatology Information Center Archive
Investigators sought to determine the association between liver fibrosis and hepatitis B virus genotype G in patients with comorbid HIV and HBV.
The Advisory Committee on Immunization Practices Hepatitis Vaccines Work Group has updated recommendations for hepatitis A vaccination for PEP and PrEP.
Those with HCV genotype 1 with recent injection drug use and/or current opioid substitution therapy, paritaprevir/ritonavir, ombitasvir, and dasabuvir with/without ribavirin is effective.
Second study shows no significant difference in patients' survival based on donor BMI.
Patients with chronic HCV undergoing short-term glecaprevir and pibrentasvir treatment show improved cardiovascular and metabolic extrahepatic manifestations.
Findings based on birth cohort, risk-based testing vs opt-out testing in prison system.
The Company has completed a first in human study in healthy volunteers; a Phase 2 trial in adults with NASH is due to begin soon in the US.
The approval was based on data from the KEYNOTE-224 study, a single-arm trial in patients with HCC who had disease progression on or after sorafenib or were intolerant to sorafenib; had measurable disease; and Child-Pugh class A liver impairment.
Adherence to the American Association for the Study of Liver Diseases criteria for evaluation and treatment of chronic HBV infection was found to be poor in all practice settings assessed.
Investigators aimed to determine rates and predictors of cirrhosis and cirrhosis-related complications in patients with chronic hepatitis B infection.
Overall, 1.7 and 1.0% of all US adults HCV antibody-positive and HCV RNA-positive.
The introduction of DAAs has caused a significant reduction in the percentage of liver transplant recipients for HCV who are viremic after surgery.
Candidates who accept organ from older donor have lower mortality within and beyond 90 days
Universal 1-time screening for chronic HCV infection is cost-effective compared with no screening or with birth cohort-based screening alone.
The American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) released updates guidelines for treating hepatitis C infection.
Similar weight, liver enzyme improvements seen with group- and web-based programs for NAFLD patients.
But drinking 1.5 drinks/day linked to increased mortality after adjustment for multiple confounders.
The study authors searched MEDLINE from inception through July 2018 to obtain relevant cohort studies and randomized trials assessing HBVr incidence secondary to pharmaceutical agents.
One of the goals of the US Department of Health and Human Services National Viral Hepatitis Action Plan is to eliminate mother-to-infant transmission of HCV infection.
Investigators examined treatment response of sofosbuvir-based DAA in patients with chronic hepatitis C with compensated liver cirrhosis in a community care setting.
Analysis of 2 phase 3 clinical trials evaluating the safety/efficacy of glecaprevir/pibrentasvir in people with HCV coinfected with HIV-1 found an overall sustained virologic response of 98% at week 12 of treatment in those with or without cirrhosis.
The first human case of a strain of hepatitis E previously found only in rats was diagnosed in a Hong Kong man who received a liver transplant in May 2017.
Barriers found among PCPs in surveillance of HCC indicate the need for clinical interventions, including provider education.
The PELD score underestimates the actual probability of 90-day pretransplant mortality for children undergoing a primary liver transplant.
Inspection at the VIP Spa in Albuquerque detected practices that might spread HIV or hepatitis B and C.
Curing HCV infection with direct-acting antiretrovirals is associated with regression of liver fibrosis for most patients.
The researchers found a significant difference in mean time to direct-acting antiviral agent treatment among participants with public insurance payers compared with private insurance payers.
The neuropsychiatric symptoms associated with HCV infection are likely caused by the body's response to the virus' effects on brain function.
A robust anamnestic response was mounted in most adolescents when challenged with a dose of monovalent HBV vaccine.
There is an opportunity to improve HCV treatment rates for people who inject drugs by integrating DAA therapy into current models of community-based addiction.
Direct-acting antivirals are safe and effective in African-American patients with chronic HCV.
In high-volume centers, patients with liver metastases from colorectal cancer may often be eligible for minimally invasive liver surgery via laparoscopy, thereby reducing potential morbidity risks associated with open surgery.
All 20 recipients experienced HCV cure, good quality of life, excellent renal function.
Circulating hepatic markers may predict the risk for diabetes in women.
Investigators added hepatitis C virus and HIV screening tests to standard trauma activation laboratory orders.
Drop in median price of WHO-prequalified generic tenofovir from 208 to 32 from 2004 to 2016
Coordinated treatment programs may improve treatment outcomes in patients with hepatitis C infection.
Adults aged 25 to 34 show greatest relative increase in mortality, driven by alcoholic cirrhosis.
Adherence and completion to multidose vaccine schedules for hepatitis A, B, and A-B are low, thereby rendering vaccination ineffective.
Project ECHO at Los Angeles Christian Health Center contributes to improved care of HCV in underserved populations.
From 2007 to 2015, the majority of initial hepatitis A, B, and A/B vaccinations were administered by primary care providers.
Patients with chronic hepatitis B have a lower risk of hepatic events if they achieve normal on-treatment ALT in the first 12 months of NA treatment.
Of the 2500 cases of hepatitis A infection reported between January 2017 and April 2018, 68% were among persons who reported drug use (injection and non-injection), homelessness, or both.
Successful DAA therapy may lead to cognitive improvement in several domains in HCV-infected patients.
Costs were significantly higher than total annual costs per matched control with similar comorbidities.
Low screening rate seen at same time as increase in hepatitis C virus prevalence among pregnant women
The Respectful & Equitable Access to Comprehensive Healthcare program obtained 93% of prior authorization approvals for hepatitis C medications.
A proposed novel Medicaid purchasing strategy is anticipated to increase access to medications that can eradicate hepatitis C virus infection without increasing costs at the state and federal levels.
Patients with mild, moderate renal impairment showed improvement in renal biomarkers over one year
Researchers conducted the first systematic review and meta-analysis to assess the relationship between HBV and the risk for coronary heart disease.
Benefits of protection with 2 doses administered over 1 month make the vaccine an important option for prevention of HBV.
A 72-year-old Japanese woman with a 40-year history of lupus nephritis presented with leg edema that had lasted for several weeks.
Future studies might focus on the use of electronic medical record warning systems or other prompts to improve diagnostic test use in at-risk individuals.
Metabolic syndrome also associated with higher alanine aminotransferase levels longitudinally
Screening prevalence 11.5 to 12.8%; similar rate for cohort born from 1966 to 1985
In this large, real-world cohort of patients with chronic hepatitis C virus infection, equivalent sustained virologic response rates were found with both 8-week and 12-week treatment.
End-of-treatment HBsAg levels may be a clinically useful biomarker to predict HBV relapse in patients with chronic hepatitis B regardless of HBeAg status.
Increased adiposity in childhood may negatively impact liver function in children as young as 8 years old.
Direct-acting antivirals improved the survival of patients undergoing liver transplantation for HCV-related liver disease.
BMI is positively correlated with increased hepatocellular carcinoma in patients with chronic HBV, though the risk is greater in women.
Hepatitis C virus eradication by direct antiviral agents improves carotid atherosclerosis in patients with advanced fibrosis and compensated cirrhosis.
Prophylaxis safely, effectively prevents HCV transmittance in noninfected patients receiving kidney transplants from HCV-positive donors.
TDF did not reduce mother-to-child HBV transmission in mothers taking hepatitis B Ig and HBV vaccine.
Elbasvir and grazoprevir, taken in combination for 12 weeks, successfully treated virologic response in patient with hepatitis C genotype 1b.
Technical variant grafts may be better than whole grafts for living donor liver transplants in children.
The Work Group who authored the new recommendations was made up of professionals from academic medicine, federal and state public health agencies, and medical societies.
Once daily glecaprevir-pibrentasvir for 8 or 12 weeks successfully treated HCV genotype 1 and 3.
Primary gastrinomas of the hepatobiliary tract may occur in patients with Zollinger-Ellison syndrome
Lymph nodes proximal to hepatic or biliary gastrinomas will likely require extraction as many in the surround region will have metastasized.
Patients with chronic HCV with a sustained virologic response were more likely to have a reduced progression of liver fibrosis.
The Food and Drug Administration (FDA) has approved Heplisav-B for the prevention of infection caused by all known subtypes of hepatitis B virus.
Hepatitis B and hepatitis C may increase mortality risks in HIV patients.
A 38-year old nonalcoholic patient consumed Epsom salt in large quantities for a short period of time and developed jaundice and steatohepatitis.
Mislabeling of herbal and dietary supplements is common, occurring in more than half of products tested.
Aspirin therapy is associated with a reduced risk of hepatitis B virus-related hepatocellular carcinoma.
The American Association for the Study of Liver Diseases and the Infectious Diseases Society of America have added updates to the hepatitis C guidelines to include kidney transplant, pregnant, and pediatric patients.
The FDA has approved Opdivo (nivolumab) injection for the treatment of patients with HCC who have been previously treated with sorafenib.
The 3-part plan to halt the outbreak of hepatitis A focuses on immunization, sanitation and education with most of the efforts focused on the homeless population who are the most at-risk population.
The results show no evidence to support a hypothesis of differential impact of interferon and direct-acting antiviral-based cure on risk for HCC occurrence and recurrence.
Patients with childhood-onset IBD have an increased risk of cancer, especially gastrointestinal cancers, lymphoid neoplasms, and skin cancer,
No significant association was observed between coffee consumption and risk of biliary tract cancer, but there was evidence of an inverse correlation between coffee consumption and liver cancer risk.
A Mediterranean diet with antioxidant supplementation contributes to improving lipid profile and insulin sensitivity parameters in patients with non-alcoholic fatty liver disease.
The increase in the demand for liver transplantation for nonalcoholic steatohepatitis is expected to continue with the current population obesity trends.
The American Academy of Pediatrics recommends that the first dose of the hepatitis B vaccine should be given within the first 24 hours of life.
Primary care providers and nurse practitioners achieve the same sustained virologic response rates as specialists.
The AAFP has created an alcohol screening practice manual to help family physicians prevent alcohol misuse.
The use of palliative care increased from 2006 to 2012 among patients with end-stage liver disease.
The prompt increased hepatitis C screening rates among baby boomers in primary care by 5-fold.
Telbivudine administered during early and middle pregnancy prevented hepatitis B transmission from mother to infants in all participants receiving antiviral treatment.
HIV, hepatitis B, and hepatitis C infections are more common among individuals with severe mental illness.
The update includes 30 new medicines for adults and 25 for children and groups antibiotics into 3 distinct categories.
The score could help predict advanced colorectal neoplasia in adults younger than 50 years of age.
The Rotterdam Study found that frequent coffee and herbal tea consumption is associated with lower liver stiffness in the general population.
Hepatitis C treatment in HIV coinfection cases is effective with standardized nurse and pharmacist support for patients in an urban clinic.
The universal vaccination against hepatitis B virus infection prevented non-Hodgkin lymphoma in adolescents.
Researchers conducted a meta-analysis to determine the association between coffee consumption and risk of hepatocellular carcinoma.
Pregnant women with a high hepatitis B viral load who receive tenofovir have a reduced risk for passing the virus to their child.
The guideline is intended to be an educational device to provide information that may assist endoscopists in providing care to patients.
The researchers found that the average survival after surgery for those receiving capecitabine was longer compared with those who only had surgery.
Gluten-rich food may lead to symptom onset, specifically early satiety, in patients with functional dyspepsia.
The guidelines facilitate a holistic, lifelong approach to the management of patients with primary biliary cholangitis.