Hepatology Information Center Archive

Modest Alcohol Consumption May Reduce Mortality in NAFLD

But drinking 1.5 drinks/day linked to increased mortality after adjustment for multiple confounders.

Rituximab Linked to HBV Reactivation in Patients With Prior Functional Cure

The study authors searched MEDLINE from inception through July 2018 to obtain relevant cohort studies and randomized trials assessing HBVr incidence secondary to pharmaceutical agents.

Need for Adequate Screening for Infants With HCV Infected Mothers During Pregnancy

One of the goals of the US Department of Health and Human Services National Viral Hepatitis Action Plan is to eliminate mother-to-infant transmission of HCV infection.

Sofosbuvir-Based Regimens Safe, Effective for Chronic Hepatitis C in the Community

Investigators examined treatment response of sofosbuvir-based DAA in patients with chronic hepatitis C with compensated liver cirrhosis in a community care setting.

Glecaprevir/Pibrentasvir Is Safe, Efficacious for HCV/HIV-1 Coinfection

Analysis of 2 phase 3 clinical trials evaluating the safety/efficacy of glecaprevir/pibrentasvir in people with HCV coinfected with HIV-1 found an overall sustained virologic response of 98% at week 12 of treatment in those with or without cirrhosis.

First Human Case of Rat Strain of Hepatitis E Found

The first human case of a strain of hepatitis E previously found only in rats was diagnosed in a Hong Kong man who received a liver transplant in May 2017.

Barriers Found in PCP Knowledge of Surveillance of Hepatocellular Carcinoma

Barriers found among PCPs in surveillance of HCC indicate the need for clinical interventions, including provider education.

Pediatric End-Stage Liver Disease Score Underestimates Mortality

The PELD score underestimates the actual probability of 90-day pretransplant mortality for children undergoing a primary liver transplant.

Patrons of 'Vampire Facial' Spa May Have Been Exposed to HIV

Inspection at the VIP Spa in Albuquerque detected practices that might spread HIV or hepatitis B and C.

HCV DAA Curative Therapy Associated With Liver Fibrosis Regression

Curing HCV infection with direct-acting antiretrovirals is associated with regression of liver fibrosis for most patients.

Factors Associated With Faster Time to Hepatitis C Treatment

The researchers found a significant difference in mean time to direct-acting antiviral agent treatment among participants with public insurance payers compared with private insurance payers.

HCV Neuropsychiatric Symptoms Likely Linked to Virus' Effects on Brain Function

The neuropsychiatric symptoms associated with HCV infection are likely caused by the body's response to the virus' effects on brain function.

HBV Antibody Persistence in Adolescents Vaccinated With DTPa-HBV-IPV/Hib as Infants

A robust anamnestic response was mounted in most adolescents when challenged with a dose of monovalent HBV vaccine.

Toward Integrated Care for Hepatitis C Infection and Addiction

There is an opportunity to improve HCV treatment rates for people who inject drugs by integrating DAA therapy into current models of community-based addiction.

Real-World Efficacy of DAAs in African Americans With Chronic HCV GT-1 Infection

Direct-acting antivirals are safe and effective in African-American patients with chronic HCV.

Majority of Patients With Liver Metastases From Colorectal Cancer Eligible for Laparoscopy

In high-volume centers, patients with liver metastases from colorectal cancer may often be eligible for minimally invasive liver surgery via laparoscopy, thereby reducing potential morbidity risks associated with open surgery.

Good Outcomes for HCV-Negative Recipients of HCV Kidneys

All 20 recipients experienced HCV cure, good quality of life, excellent renal function.

Hepatic Markers Linked to Early Predictors of Type 2 Diabetes Risk in Women

Circulating hepatic markers may predict the risk for diabetes in women.

Successful Screening and Referral for HIV, Hepatitis C in a Trauma Population

Investigators added hepatitis C virus and HIV screening tests to standard trauma activation laboratory orders.

Availability of Generic Antivirals for Hepatitis B Increasing

Drop in median price of WHO-prequalified generic tenofovir from 208 to 32 from 2004 to 2016

Coordinated Care Enhances Access to Hepatitis C Antiviral Treatment

Coordinated treatment programs may improve treatment outcomes in patients with hepatitis C infection.

Liver Disease-Related Deaths Up Sharply From 1999 to 2016

Adults aged 25 to 34 show greatest relative increase in mortality, driven by alcoholic cirrhosis.

Poor Adherence Contributes to Inadequate Uptake of Multidose Hepatitis Vaccine Schedules

Adherence and completion to multidose vaccine schedules for hepatitis A, B, and A-B are low, thereby rendering vaccination ineffective.

Project ECHO: Educational Support to Improve Hepatitis Care

Project ECHO at Los Angeles Christian Health Center contributes to improved care of HCV in underserved populations.

Demographic Insights Into Hepatitis Vaccination Practices

From 2007 to 2015, the majority of initial hepatitis A, B, and A/B vaccinations were administered by primary care providers.

Normal on-Treatment ALT Linked to Reduced Hepatic Events in Hepatitis B

Patients with chronic hepatitis B have a lower risk of hepatic events if they achieve normal on-treatment ALT in the first 12 months of NA treatment.

CDC Issues Updated Advisory Regarding Outbreaks of Hepatitis A

Of the 2500 cases of hepatitis A infection reported between January 2017 and April 2018, 68% were among persons who reported drug use (injection and non-injection), homelessness, or both.

DAA Therapy May Improve Select Cognitive Domains in HCV-Infected Patients

Successful DAA therapy may lead to cognitive improvement in several domains in HCV-infected patients.

High Costs for Diagnosis, Care of Nonalcoholic Fatty Liver Disease

Costs were significantly higher than total annual costs per matched control with similar comorbidities.

Hepatitis C-Exposed Infants Not Adequately Screened

Low screening rate seen at same time as increase in hepatitis C virus prevalence among pregnant women

Healthcare Program Obtains 93% of Prior Authorization Approvals for HCV Medications

The Respectful & Equitable Access to Comprehensive Healthcare program obtained 93% of prior authorization approvals for hepatitis C medications.

Novel Medicaid Strategy Proposed to Increase Access to HCV Treatment

A proposed novel Medicaid purchasing strategy is anticipated to increase access to medications that can eradicate hepatitis C virus infection without increasing costs at the state and federal levels.

Sofosbuvir Improves Renal Safety in Patients With Chronic Hepatitis C

Patients with mild, moderate renal impairment showed improvement in renal biomarkers over one year

HBV Infection May Not Be Associated With Increased Risk for Coronary Heart Disease

Researchers conducted the first systematic review and meta-analysis to assess the relationship between HBV and the risk for coronary heart disease.

CDC: Recommendations on the Use of Heplisav-B Published

Benefits of protection with 2 doses administered over 1 month make the vaccine an important option for prevention of HBV.

Case Report: Nephrotic Syndrome and Chronic HCV in a 72-Year-Old Woman

A 72-year-old Japanese woman with a 40-year history of lupus nephritis presented with leg edema that had lasted for several weeks.

More Comprehensive HDV Surveillance Needed in High-Risk Individuals

Future studies might focus on the use of electronic medical record warning systems or other prompts to improve diagnostic test use in at-risk individuals.

Metabolic Syndrome Common With Chronic Hepatitis B Infection

Metabolic syndrome also associated with higher alanine aminotransferase levels longitudinally

Hepatitis C Screening Increasing Among Baby Boomers

Screening prevalence 11.5 to 12.8%; similar rate for cohort born from 1966 to 1985

Effectiveness of Shortened Treatment Regimen for Hepatitis C Assessed

In this large, real-world cohort of patients with chronic hepatitis C virus infection, equivalent sustained virologic response rates were found with both 8-week and 12-week treatment.

End-of-Treatment HBsAg Levels May Predict HBV Relapse in Chronic Hepatitis B

End-of-treatment HBsAg levels may be a clinically useful biomarker to predict HBV relapse in patients with chronic hepatitis B regardless of HBeAg status.

Obesity Can Negatively Affect Liver in Children As Young As 8

Increased adiposity in childhood may negatively impact liver function in children as young as 8 years old.

Direct-Acting Antivirals Improve Liver Transplant Survival

Direct-acting antivirals improved the survival of patients undergoing liver transplantation for HCV-related liver disease.

BMI associated with hepatocellular carcinoma risk for patients with chronic hepatitis B virus

BMI is positively correlated with increased hepatocellular carcinoma in patients with chronic HBV, though the risk is greater in women.

HCV treatment with direct antiviral agents improves carotid atherosclerosis

Hepatitis C virus eradication by direct antiviral agents improves carotid atherosclerosis in patients with advanced fibrosis and compensated cirrhosis.

Prophylaxis may protect kidney recipients from HCV

Prophylaxis safely, effectively prevents HCV transmittance in noninfected patients receiving kidney transplants from HCV-positive donors.

Maternal TDF not effective in reducing hepatitis B transmission

TDF did not reduce mother-to-child HBV transmission in mothers taking hepatitis B Ig and HBV vaccine.

Drug combination effective for hepatitis C

Elbasvir and grazoprevir, taken in combination for 12 weeks, successfully treated virologic response in patient with hepatitis C genotype 1b.

Alternatives to whole liver transplants possible for children

Technical variant grafts may be better than whole grafts for living donor liver transplants in children.

Hepatitis B infection prevention: ACIP updated recommendations

The Work Group who authored the new recommendations was made up of professionals from academic medicine, federal and state public health agencies, and medical societies.

Once daily glecaprevir-pibrentasvir treats HCV genotype 1,3

Once daily glecaprevir-pibrentasvir for 8 or 12 weeks successfully treated HCV genotype 1 and 3.

Primary gastrinomas of the hepatobiliary tract may occur in patients with Zollinger-Ellison syndrome

Lymph nodes proximal to hepatic or biliary gastrinomas will likely require extraction as many in the surround region will have metastasized.

HCV treatment hinders liver fibrosis progression

Patients with chronic HCV with a sustained virologic response were more likely to have a reduced progression of liver fibrosis.

FDA approves Heplisav-B vaccine for hepatitis B treatment

The Food and Drug Administration (FDA) has approved Heplisav-B for the prevention of infection caused by all known subtypes of hepatitis B virus.

Hepatitis increases mortality rates in HIV patients

Hepatitis B and hepatitis C may increase mortality risks in HIV patients.

Epsom salt may cause liver injury in predisposed patients

A 38-year old nonalcoholic patient consumed Epsom salt in large quantities for a short period of time and developed jaundice and steatohepatitis.

Herbal, dietary supplements commonly mislabeled

Mislabeling of herbal and dietary supplements is common, occurring in more than half of products tested.

Aspirin use associated with a reduced risk of HCC in hepatitis B patients

Aspirin therapy is associated with a reduced risk of hepatitis B virus-related hepatocellular carcinoma.

Updated hepatitis C recommendations include kidney transplant, pregnant patients

The American Association for the Study of Liver Diseases and the Infectious Diseases Society of America have added updates to the hepatitis C guidelines to include kidney transplant, pregnant, and pediatric patients.

FDA approves Opdivo for treatment of hepatocellular carcinoma

The FDA has approved Opdivo (nivolumab) injection for the treatment of patients with HCC who have been previously treated with sorafenib.

Combating the hepatitis A outbreak in San Diego

The 3-part plan to halt the outbreak of hepatitis A focuses on immunization, sanitation and education with most of the efforts focused on the homeless population who are the most at-risk population.

Hepatocellular carcinoma risk unclear after hepatitis C treatment

The results show no evidence to support a hypothesis of differential impact of interferon and direct-acting antiviral-based cure on risk for HCC occurrence and recurrence.

Pediatric inflammatory bowel disease increases cancer risk in adulthood

Patients with childhood-onset IBD have an increased risk of cancer, especially gastrointestinal cancers, lymphoid neoplasms, and skin cancer,

Coffee consumption associated with reduced liver cancer risk, no link to biliary tract cancer

No significant association was observed between coffee consumption and risk of biliary tract cancer, but there was evidence of an inverse correlation between coffee consumption and liver cancer risk.

Mediterranean diet, antioxidant supplements beneficial for non-alcoholic fatty liver disease

A Mediterranean diet with antioxidant supplementation contributes to improving lipid profile and insulin sensitivity parameters in patients with non-alcoholic fatty liver disease.

Demand for liver transplant for nonalcoholic steatohepatitis expected to continue

The increase in the demand for liver transplantation for nonalcoholic steatohepatitis is expected to continue with the current population obesity trends.

AAP: Hepatitis B vaccine should be given within first 24 hours of life

The American Academy of Pediatrics recommends that the first dose of the hepatitis B vaccine should be given within the first 24 hours of life.

Primary care providers and nurse practitioners can expand HCV treatment access

Primary care providers and nurse practitioners achieve the same sustained virologic response rates as specialists.

Alcohol screening and brief intervention: A practice manual for clinicians

The AAFP has created an alcohol screening practice manual to help family physicians prevent alcohol misuse.

Use of palliative care increases in patients with end-stage liver disease

The use of palliative care increased from 2006 to 2012 among patients with end-stage liver disease.

Electronic health record-based prompt increases hepatitis C screenings in baby boomers

The prompt increased hepatitis C screening rates among baby boomers in primary care by 5-fold.

Telbivudine prevents hepatitis B transmission during early pregnancy

Telbivudine administered during early and middle pregnancy prevented hepatitis B transmission from mother to infants in all participants receiving antiviral treatment.

Blood-borne viruses more common in patients with severe mental illness

HIV, hepatitis B, and hepatitis C infections are more common among individuals with severe mental illness.

WHO updates Essential Medicines List, recommendations for antibiotics

The update includes 30 new medicines for adults and 25 for children and groups antibiotics into 3 distinct categories.

Risk-scoring model predicts advanced colorectal neoplasia in younger adults

The score could help predict advanced colorectal neoplasia in adults younger than 50 years of age.

Frequent coffee and herbal tea consumption linked to lower liver stiffness

The Rotterdam Study found that frequent coffee and herbal tea consumption is associated with lower liver stiffness in the general population.

High HCV cure rates in patients with HIV coinfection at urban clinic

Hepatitis C treatment in HIV coinfection cases is effective with standardized nurse and pharmacist support for patients in an urban clinic.

Hepatitis B vaccine reduces risk of non-Hodgkin lymphoma in adolescents

The universal vaccination against hepatitis B virus infection prevented non-Hodgkin lymphoma in adolescents.

Increased coffee consumption may reduce risk of hepatocellular carcinoma

Researchers conducted a meta-analysis to determine the association between coffee consumption and risk of hepatocellular carcinoma.

Tenofovir prevents prenatal transmission of HBV in pregnancy

Pregnant women with a high hepatitis B viral load who receive tenofovir have a reduced risk for passing the virus to their child.

Endoscopy's role in primary sclerosing cholangitis: a clinical guideline

The guideline is intended to be an educational device to provide information that may assist endoscopists in providing care to patients.

ASCO: Capecitabine may prolong survival in patients with biliary tract cancer

The researchers found that the average survival after surgery for those receiving capecitabine was longer compared with those who only had surgery.

Gluten consumption affects symptom onset in functional dyspepsia

Gluten-rich food may lead to symptom onset, specifically early satiety, in patients with functional dyspepsia.

Primary biliary cholangitis: A clinical practice guideline

The guidelines facilitate a holistic, lifelong approach to the management of patients with primary biliary cholangitis.

EASL releases updated guidelines for managing hepatitis B virus infection

The updated guidelines include substantial changes in the management of hepatitis B based on the latest scientific evidence.

Zinc effective in children with presymptomatic Wilson disease

Treatment was effective in patients under 6 years who received 50 mg/day of zinc as an initial dose.

HCV transmission knowledge varies among opioid-dependent pregnant patients

Most opioid-dependent pregnant patients understand that intravenous drug use is a major transmission modality of HCV.

Statins may lower risk of cirrhosis decompensation in HBV and HCV

Statin use decreased rates of decompensation in patients with liver cirrhosis due to HBV and HCV infections and in patients with alcohol-induced cirrhosis.

AGA Institute releases practice update for managing patients cured of HCV infection

Patients with chronic HCV infection who have achieved a sustained virologic response with treatment may still be at risk for complications such as hepatocellular carcinoma.

Metastatic pancreatic cancer: a new clinical practice guideline

The guideline will help clinicians determine the appropriate treatment of patients with metastatic pancreatic cancer.

NASEM report aims to eliminate hepatitis B and C by 2030

Aggressive testing, diagnosis, treatment, and prevention methods, such as needle exchange for those who inject drugs, are some of the options that the NASEM explored to target hepatitis elimination.

FDA approves first direct-acting antivirals for pediatric HCV patients

Harvoni and Sovaldi have been approved for pediatric patients with HCV genotypes.

Oral, direct-acting antivirals effective for hepatitis C virus infection

Regimens for the treatment of hepatitis C that included ribavirin had more mild or moderate adverse events than those without.

Pharmacists can help optimize care in patients with hepatitis C virus

Drug-drug interactions are common in patients taking hepatitis C virus medications, and consulting with a pharmacist can be beneficial.

High BMI in late adolescence associated with increased risk of severe liver disease in men

A high BMI is associated with an increased risk for severe liver disease, and the risk is higher in those who also have type 2 diabetes mellitus.

FODMAP diet effective for irritable bowel syndrome

Implementation of the FODMAP diet is an effective strategy to manage symptoms of IBS, including bloating and abdominal pain.

Gluten challenge not effective for confirming non-celiac gluten sensitivity

Thirty-eight of 231 NCGS patients showed gluten-specific symptoms when completing the placebo-controlled gluten challenge.

Evaluating abnormal liver chemistries: a clinical guideline

The American College of Gastroenterology has released recommendations of preferred approaches for diagnosing and evaluating patients with abnormal liver test results.

Acute pancreatitis may reveal pancreatic cancer at earlier stage

Surgical intervention after 24.5 days of acute pancreatitis may be beneficial for reducing postoperative complications.

Personalized treatment for very early stage hepatocellular carcinoma

Investigators have proposed an algorithm to facilitate the decision-making process of clinical care for patients with very early hepatocellular carcinoma.

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