Hepatology

Updated Recommendations, Hepatitis A Vaccine Postexposure Prophylaxis and Travel

Updated Recommendations, Hepatitis A Vaccine Postexposure Prophylaxis and Travel

The Advisory Committee on Immunization Practices Hepatitis Vaccines Work Group has updated recommendations for hepatitis A vaccination for PEP and PrEP.

Survival Similar With Donor Hearts From Hepatitis C+ Donors

Survival Similar With Donor Hearts From Hepatitis C+ Donors

Second study shows no significant difference in patients' survival based on donor BMI.

New Four Drug Regimen Effective in Patients With HCV Who Inject Drugs

New Four Drug Regimen Effective in Patients With HCV Who Inject Drugs

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Those with HCV genotype 1 with recent injection drug use and/or current opioid substitution therapy, paritaprevir/ritonavir, ombitasvir, and dasabuvir with/without ribavirin is effective.

Glecaprevir and Pibrentasvir Improve Extrahepatic Manifestations in Hepatitis C

Glecaprevir and Pibrentasvir Improve Extrahepatic Manifestations in Hepatitis C

Patients with chronic HCV undergoing short-term glecaprevir and pibrentasvir treatment show improved cardiovascular and metabolic extrahepatic manifestations.

Targeted HCV Testing Misses High Number of Cases in Prisons

Targeted HCV Testing Misses High Number of Cases in Prisons

Findings based on birth cohort, risk-based testing vs opt-out testing in prison system.

Novel NASH Treatment Gets FDA's Fast Track Designation

Novel NASH Treatment Gets FDA's Fast Track Designation

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The Company has completed a first in human study in healthy volunteers; a Phase 2 trial in adults with NASH is due to begin soon in the US.

Keytruda Gets FDA Approval for Hepatocellular Carcinoma

Keytruda Gets FDA Approval for Hepatocellular Carcinoma

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The approval was based on data from the KEYNOTE-224 study, a single-arm trial in patients with HCC who had disease progression on or after sorafenib or were intolerant to sorafenib; had measurable disease; and Child-Pugh class A liver impairment.

Suboptimal Rates of Adherence to Chronic HBV Treatment Guidelines Identified

Suboptimal Rates of Adherence to Chronic HBV Treatment Guidelines Identified

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Adherence to the American Association for the Study of Liver Diseases criteria for evaluation and treatment of chronic HBV infection was found to be poor in all practice settings assessed.

High Prevalence of Cirrhosis in Adults With Chronic HBV at a Safety-Net Hospital

High Prevalence of Cirrhosis in Adults With Chronic HBV at a Safety-Net Hospital

Investigators aimed to determine rates and predictors of cirrhosis and cirrhosis-related complications in patients with chronic hepatitis B infection.

Universal vs Risk-Based Screening in Pregnancy: An Expert Weighs In

Universal vs Risk-Based Screening in Pregnancy: An Expert Weighs In

There is a lack of consensus among experts and professional organizations whether HCV screening in pregnant women should be risk based or universal.

Over 2 Million People Living With HCV From 2013 to 2016

Over 2 Million People Living With HCV From 2013 to 2016

Overall, 1.7 and 1.0% of all US adults HCV antibody-positive and HCV RNA-positive.

ACS: Accepting Liver From Older Donor Better Than Waiting

ACS: Accepting Liver From Older Donor Better Than Waiting

Candidates who accept organ from older donor have lower mortality within and beyond 90 days

Direct-Acting Agents Help to Eliminate Hepatitis C in Liver Transplant Recipients

Direct-Acting Agents Help to Eliminate Hepatitis C in Liver Transplant Recipients

The introduction of DAAs has caused a significant reduction in the percentage of liver transplant recipients for HCV who are viremic after surgery.

One-Time, Universal Screening for Hepatitis C Is Cost-Effective

One-Time, Universal Screening for Hepatitis C Is Cost-Effective

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Universal 1-time screening for chronic HCV infection is cost-effective compared with no screening or with birth cohort-based screening alone.

Updated HCV Treatment Guidelines for 2018 Published by AASLD-IDSA

Updated HCV Treatment Guidelines for 2018 Published by AASLD-IDSA

The American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) released updates guidelines for treating hepatitis C infection.

Web-Based Lifestyle Program Beneficial for Liver Disease Patients

Web-Based Lifestyle Program Beneficial for Liver Disease Patients

Similar weight, liver enzyme improvements seen with group- and web-based programs for NAFLD patients.

Modest Alcohol Consumption May Reduce Mortality in NAFLD

Modest Alcohol Consumption May Reduce Mortality in NAFLD

But drinking 1.5 drinks/day linked to increased mortality after adjustment for multiple confounders.

Rituximab Linked to HBV Reactivation in Patients With Prior Functional Cure

Rituximab Linked to HBV Reactivation in Patients With Prior Functional Cure

The study authors searched MEDLINE from inception through July 2018 to obtain relevant cohort studies and randomized trials assessing HBVr incidence secondary to pharmaceutical agents.

Need for Adequate Screening for Infants With HCV Infected Mothers During Pregnancy

Need for Adequate Screening for Infants With HCV Infected Mothers During Pregnancy

One of the goals of the US Department of Health and Human Services National Viral Hepatitis Action Plan is to eliminate mother-to-infant transmission of HCV infection.

Sofosbuvir-Based Regimens Safe, Effective for Chronic Hepatitis C in the Community

Sofosbuvir-Based Regimens Safe, Effective for Chronic Hepatitis C in the Community

Investigators examined treatment response of sofosbuvir-based DAA in patients with chronic hepatitis C with compensated liver cirrhosis in a community care setting.

First Human Case of Rat Strain of Hepatitis E Found

First Human Case of Rat Strain of Hepatitis E Found

The first human case of a strain of hepatitis E previously found only in rats was diagnosed in a Hong Kong man who received a liver transplant in May 2017.

Barriers Found in PCP Knowledge of Surveillance of Hepatocellular Carcinoma

Barriers Found in PCP Knowledge of Surveillance of Hepatocellular Carcinoma

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Barriers found among PCPs in surveillance of HCC indicate the need for clinical interventions, including provider education.

Pediatric End-Stage Liver Disease Score Underestimates Mortality

Pediatric End-Stage Liver Disease Score Underestimates Mortality

The PELD score underestimates the actual probability of 90-day pretransplant mortality for children undergoing a primary liver transplant.

HCV DAA Curative Therapy Associated With Liver Fibrosis Regression

HCV DAA Curative Therapy Associated With Liver Fibrosis Regression

Curing HCV infection with direct-acting antiretrovirals is associated with regression of liver fibrosis for most patients.

Factors Associated With Faster Time to Hepatitis C Treatment

Factors Associated With Faster Time to Hepatitis C Treatment

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The researchers found a significant difference in mean time to direct-acting antiviral agent treatment among participants with public insurance payers compared with private insurance payers.

HCV Neuropsychiatric Symptoms Likely Linked to Virus' Effects on Brain Function

HCV Neuropsychiatric Symptoms Likely Linked to Virus' Effects on Brain Function

The neuropsychiatric symptoms associated with HCV infection are likely caused by the body's response to the virus' effects on brain function.

HBV Antibody Persistence in Adolescents Vaccinated With DTPa-HBV-IPV/Hib as Infants

HBV Antibody Persistence in Adolescents Vaccinated With DTPa-HBV-IPV/Hib as Infants

A robust anamnestic response was mounted in most adolescents when challenged with a dose of monovalent HBV vaccine.

Real-World Efficacy of DAAs in African Americans With Chronic HCV GT-1 Infection

Real-World Efficacy of DAAs in African Americans With Chronic HCV GT-1 Infection

Direct-acting antivirals are safe and effective in African-American patients with chronic HCV.

Toward Integrated Care for Hepatitis C Infection and Addiction

Toward Integrated Care for Hepatitis C Infection and Addiction

There is an opportunity to improve HCV treatment rates for people who inject drugs by integrating DAA therapy into current models of community-based addiction.

Majority of Patients With Liver Metastases From Colorectal Cancer Eligible for Laparoscopy

Majority of Patients With Liver Metastases From Colorectal Cancer Eligible for Laparoscopy

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In high-volume centers, patients with liver metastases from colorectal cancer may often be eligible for minimally invasive liver surgery via laparoscopy, thereby reducing potential morbidity risks associated with open surgery.

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