HIV/AIDS Information Center Archive

2014 to 2016 Saw 470% Increase in HIV PrEP Use in US

Seven percent of those with indications for PrEP were prescribed PrEP, including 2.1% of women.

Glecaprevir/Pibrentasvir Is Safe, Efficacious for HCV/HIV-1 Coinfection

Analysis of 2 phase 3 clinical trials evaluating the safety/efficacy of glecaprevir/pibrentasvir in people with HCV coinfected with HIV-1 found an overall sustained virologic response of 98% at week 12 of treatment in those with or without cirrhosis.

A Single Combination Tablet Suppresses HIV Load Through 48 Weeks

A combination single tablet once-a-day regimen of doravirine/lamivudine/tenofovir disoproxil fumarate demonstrated non-inferiority and no significant adverse events when compared with continuation of established antiretroviral therapy in adults infected with HIV-1.

HIV Infection Diagnoses on the Rise in Young Homosexual Men

Number of HIV diagnoses in those aged 13 to 29 4x higher than those aged 50 years.

Patrons of 'Vampire Facial' Spa May Have Been Exposed to HIV

Inspection at the VIP Spa in Albuquerque detected practices that might spread HIV or hepatitis B and C.

FDA Approves Two New Oral Treatments for HIV-1 Infection

Delstrigo is approved as a complete regimen whereas Pifeltro is to be administered in combination with other antiretrovirals.

Risk of Thyroid Dysfunction Not Associated With HIV Status

Compared with uninfected individuals, people with HIV controlled with combination antiretroviral therapy are not at increased risk of developing thyroid dysfunction.

Patient Navigation Associated With Positive Outcomes in HIV

Patient navigation may be considered an effective strategy to enhance engagement and continuation in disease treatment among people with HIV.

1997 to 2015 Saw Increase in HIV Viral Suppression Rates

Lower odds of having detectable viral load for older adults and those using ISTI-based regimen.

Ibalizumab Active in Multidrug Resistant HIV-1 Infection

Lower degree of susceptibility to ibalizumab for 9 of 10 patients with virology failure, rebound.

International Antiviral Society-USA Updates Recommendations for HIV Treatment and Prevention

The International Antiviral Society-USA Panel has updated its recommendations for the management and prevention of HIV infection, to reflect the most current data on new treatment regimens and strategies.

Intervention Cuts Risk for HIV in Young Transgender Women

Intervention group had greater reduction in condomless sex acts vs standard of care group.

Low Rates of Syphilis Testing in High-Risk Men Who Are HIV Positive

Close to one-third of sexually active HIV-positive men who have sex with men (MSM) have not received syphilis screening in the past 12 months.

HIV, Syphilis Screening Low With ED-Diagnosed PID in Adolescents

Findings among teens diagnosed with pelvic inflammatory disease in the emergency department.

Guidelines for ART Updated for Those With or at Risk for HIV

ART recommended for almost all HIV-infected; should be initiated as soon as possible post diagnosis.

Successful Screening and Referral for HIV, Hepatitis C in a Trauma Population

Investigators added hepatitis C virus and HIV screening tests to standard trauma activation laboratory orders.

HPV Vaccine Failure Rates May Be Higher in Women, Girls With HIV

Vaccinated women and girls living with HIV may be at greater risk for HPV vaccine failure compared with women and girls without HIV.

Single High-Dose Liposomal Amphotericin B Effectively Treats HIV-Associated Cryptococcal Meningitis

Single high-dose liposomal amphotericin B (L-AmB) is non-inferior to daily dosed L-AmB at the standard dose in treatment of fungal clearance in HIV-associated cryptococcal meningitis.

Diabetes Risk Associated With Cirrhosis, Not Chronic HCV Infection, in HIV Positive Patients

Cirrhosis is associated with an increased risk for diabetes mellitus among patients living with HIV.

Efavirenz Does Not Increase Depression, Suicidal Ideation in HIV-Infected

No increased risk of depression or suicidal ideation among persons living with HIV in Uganda.

National HIV Testing Day Is on June 27

Annual occasion is a good time for health care providers to encourage testing

FDA: Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

The Agency has received reports of serious neural tube birth defects involving the brain, spine, and spinal cord in babies born to women who received dolutegravir for HIV treatment.

CVS unintentionally reveals HIV status of 6,000 customers, per lawsuit

CVS Health faces lawsuit for revealing the HIV status of 6,000 patients in Ohio.

FDA approves antiretroviral therapy for multidrug-resistant HIV

The FDA has approved Trogarzo for heavily treated adult patients living with HIV and whose HIV infections cannot be successfully treated with other currently available therapies.

Daily dose of PrEP raises coverage, protective drug concentrations

Recommendations for daily doses of emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) resulted in protective drug concentrations for men and transgender women.

Fatigue, muscle aches more common in women with HIV than men

The two most prevalent HIV symptoms, fatigue and muscle aches, are more common in women than men and can worsen with menopause.

FDA OKs new medication for individuals with resistant HIV

A new antiretroviral HIV treatment, Trogarzo (ibalizumab-uiyk), has been approved by the FDA for patients with HIV who have not have success with past HIV medications.

Newer HIV testing options underused in Black MSM and transgender women

Increasing awareness of and access to newer HIV testing options such as free or reduced price on home and self-tests and couples HIV testing and counseling can facilitate increased levels of consistent testing among young, Black MSM, and transgender women.

Bacterial vaginosis may alter links between contraception, HIV acquisition

Bacterial vaginosis may cause an increased risk for HIV acquisition in women taking oral or injectable hormonal contraception.

Alcohol usage not linked to lower short-term CD4 cell count in HIV

Excessive alcohol consumption does not impact the decline of CD4 cell count in patients with HIV who have not undergone antiretroviral treatments.

HIV care worsened with chronicity of depression

Chronicity of depression is associated with increased likelihood of failure along the continuum of HIV care.

HIV screening at 25 years optimal for outcomes, cost

For young adults without known risk factors, a one-time routine HIV screen at 25 years would optimize clinical outcomes and be cost-effective.

Combination ART may prevent progressive brain injury in HIV patients

Post-seroconversion brain morphology can occur in HIV patients, but aviremia maintenance via cART can slow of prevent brain injuries.

HIV infection to diagnosis time decreasing

A new report from the CDC finds that HIV is being diagnosed sooner after initial infection than in previous years.

Nivolumab treatment for lung cancer may successfully deplete HIV reservoirs

Nivolumab treatment for non-small-cell lung cancer may induce successful depletion of HIV reservoir.

HIV occurrences decline in Uganda from 1999 to 2016

The decrease in HIV incidence in Uganda was facilitated by antiretroviral therapy, male circumcision, and adolescent abstinence.

Characteristics in transgender individuals may lead to more HIV tests

More tests might be administered to transgender individuals who are female, black, or sex workers.

Dual HIV treatment provides simple, safe salvage regimen

The dual combination of dolutegravir plus darunavir/ritonavir provided a simple and safe salvage therapy to suppress viral replication without metabolic impact in patients infected with HIV-1.

Hepatitis increases mortality rates in HIV patients

Hepatitis B and hepatitis C may increase mortality risks in HIV patients.

Law upheld requiring HIV-infected adults to tell sexual partners of their status

The Ohio Supreme Court has unanimously upheld the constitutionality of a law requiring HIV-infected individuals to tell their sexual partners of their illness.

CDC updates contraception recommendations for women at risk for HIV

The CDC revised its US Medical Eligibility Criteria for Contraceptive Use categorization for DMPA injection in women at high risk for HIV infection from US MEC category 1 to US MEC category 2.

Antiretroviral therapy resistance increasing in HIV treatment

Resistance to ART is threatening the recent gains of treatment in the rate of new HIV infections.

High percentage of HIV-diagnosed women not receiving care

More than half of women receiving a new HIV diagnosis have already received this diagnosis in the past but are not undergoing HIV medical care.

HIV care outcomes low for Hispanics and Latinos

Infection was diagnosed at an early stage for fewer males with infection attributed to heterosexual contact vs male-to-male sexual contact.

Chronic pain management in HIV: Updated recommendations

The HIV Medicine Association of the Infectious Disease Society of America recommends that people living with HIV be screened for pain and offered both nonpharmacologic and pharmacologic treatment options.

Single-tablet HIV treatment superior to standard therapy

Virological response, efficacy, noninferiority, and tolerability were tested for bictegravir, emtricitabine, and tenofovir alafenamide in patients with HIV.

Notification rates of HIV diagnoses increased in 16 European countries

In 16 countries, notification rates for new HIV diagnoses in older adults increased significantly, clustering in central and eastern European countries.

Once-daily HIV tablet safe for children

Elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide was well tolerated in children and maintained high virological suppression.

Vitamin D supplements may improve bone health in HIV-infected youth

High-dose vitamin D supplements improve bone mineral density in youth with HIV.

Clinical practice guideline for antiretroviral therapy in pregnant women with HIV

Alternative treatments should be offered to pregnant women with HIV instead of tenofovir or emtricitabine.

Smartphone-based electronic reader reliable for point-of-care tests in HIV and T pallidum infections

The findings shed new light on the applicability of smartphone-based electronic readers in point-of-care testing.

PrEP adherence in adolescent MSM decreases over time

Adherence decreased over time in adolescent MSM who participated in a 48-week HIV PrEP intervention.

Sexually risky behavior more common in women with mental disorders than in men

Women with mental illness engage in significantly more sexually risky behaviors than men, and personality risk scores are a significant predictor of total sex acts for women but not men.

Offering rapid HIV testing to patients increases overall testing rate in the emergency department

Rapid HIV testing offered in parallel to patient-clinician consultations increases the testing rate in the emergency department.

WHO releases new guidelines in response to pretreatment HIV drug resistance

The new guidelines address the issue of how to manage pretreatment HIV drug resistance in countries where the prevalence of is 10% or higher.

Child with HIV suppresses virus without antiretroviral therapy for more than 8 years

A child who was diagnosed with HIV at 1 month and received early treatment has suppressed the virus without anti-HIV therapy for 8.5 years.

Injectable antiretroviral therapy for as HIV effective as oral medications

The investigators found that after 32 weeks, HIV remained suppressed in 91% percent of those taking the drugs orally, 94% of those receiving monthly injections, and 95% of patients receiving injections every two months.

Blood-borne viruses more common in patients with severe mental illness

HIV, hepatitis B, and hepatitis C infections are more common among individuals with severe mental illness.

WHO updates Essential Medicines List, recommendations for antibiotics

The update includes 30 new medicines for adults and 25 for children and groups antibiotics into 3 distinct categories.

Early antiretroviral therapy initiation linked to bone loss in HIV patients

Early antiretroviral therapy initiation may increase the rate of bone loss in HIV patients.

Walgreens expands availability of PrEP for HIV prevention

Providers in 17 new Walgreens locations will be able to prescribe PrEP for HIV prevention.

FDA approves first generic version of Truvada for HIV

The drug is indicated for use in combination with other antiretroviral agents for the treatment of pediatric and adult patients with HIV-1.

HIV testing rates low in young men who have sex with men

The CDC found that 28% of young men who have sex with men have undergone HIV testing, though they account for 83% of new diagnoses.

High HCV cure rates in patients with HIV coinfection at urban clinic

Hepatitis C treatment in HIV coinfection cases is effective with standardized nurse and pharmacist support for patients in an urban clinic.

Amphotericin B superior to itraconazole for HIV-associated talaromycosis

Treatment with amphotericin B was superior to itraconazole as an induction therapy for HIV-associated talaromycosis.

Postpartum antiretroviral therapy is beneficial in HIV-positive women

Continued antiretroviral therapy was found to be safe and beneficial in HIV-positive postpartum women with high CD4+ T cell counts.

A link between antiretroviral therapy and diabetes in HIV patients?

HIV-infected patients on ART had approximately 4 and 1.5 greater odds of developing diabetes mellitus and metabolic syndrome, respectively.

Quality of life in military HIV patients affected by advanced disease and mental comorbidity

Factors linked to health-related quality of life in military HIV patients include advanced HIV disease and mental or medical comorbidity.

Conception methods available for reducing risk of transmission in HIV-discordant couples

Strategies are available to reduce the risk of HIV transmission using sperm from HIV-infected male.

HIV/AIDS epidemic could end by 2025 in the United States

Researchers predict that the infection rate could be as low as 12,000 people a year by 2025.

Nitrate inhalants (poppers) associated with increased virus-associated cancer risk in HIV-uninfected MSM

Among HIV-uninfected men aged 50 to 70, heavy popper use was associated with an increased risk of virus-associated cancer with causes linked to HPV, HHV-8, and Epstein-Barr virus.

Warfarin dosing in HIV patients with deep venous thrombosis

Results showed that mean induction times, analyzed in 170 patients, were 12.87 days in the HIV-infected patients and 11.19 days in the HIV-uninfected patients.

FDA approves label changes for two HIV drugs

The FDA Drug Interactions section has been updated to include revised information on concomitant use of corticosteroids with these drugs.

Side effects may affect medication nonadherence in patients with chronic disease

Almost half of participants reported that they never received information regarding the side effects of their medication from their prescriber.

Trained lay healthcare providers can administer HIV testing

A World Health Organization expert panel recommended lay health care workers be allowed to conduct HIV testing services using rapid diagnostic tests.

Annual rate of perinatal HIV infection decreased in United States

However, missed opportunities for prevention were common among infected infants and their mothers in recent years.

Mortality rates remain high among HIV-positive patients

The HIV-positive population of the United Kingdom has a higher risk of death than the general population, despite availability of free treatment and care.

VA offers hepatitis, HIV screening to veterans who received improper dental care

A VA center in Wisconsin is advising veterans to be screened for hepatitis and HIV after receiving care from a dentist who did not follow VA procedures.

New clinical trial underway to study efficacy of HIV vaccine

The study will be the largest HIV vaccine clinical trial to take place in South Africa.

Mortality rate from infectious diseases remains unchanged in the United States

The number of patients dying from infections has remained stable, but some disease threats have changed.

Antenatal antiretroviral therapy reduces early HIV transmission

Antenatal ART reduces rates of early HIV transmission but may increase risk of adverse maternal and neonatal outcomes.

Smoking more harmful for HIV patients than the virus

Men and women who quit smoking after entering HIV care at age 40 years gained 5.7 years and 4.6 years of life expectancy, respectively, compared with those who continued to smoke.

CDC presents updated recommendations for meningococcal vaccine in HIV

HIV-infected individuals should receive the meningococcal conjugate vaccine (serogroups A, C, W, and Y).

HIV's newly traced origins in US discredit Patient Zero theory

The study debunks the theory that Patient Zero was responsible for the AIDS epidemic in North America.

Increasing recruitment to meet demand for HIV care providers

Speakers at IDWeek 2016 addressed the demand for additional HIV care providers.

DMPA contraceptives linked to increased HIV risk

Recent data suggest that use of depot medroxyprogesterone acetate may increase women's HIV acquisition risk.

HBV and HCV coinfection increases non-Hodgkin risk in ART-treated HIV

Patients with HIV receiving antiretroviral treatment have a higher risk of non-Hodgkin's lymphoma with HBV and HCV coinfection.

Many patients with HIV have a successful response to ART

Treatment with 3 medications compared with 4 or more correlated with immune success at the end of follow-up.

Lack of epidemiologic indicators increases risk of missed HIV diagnosis

The results of a multicenter, cross-sectional study showed that 37% of patients could have been diagnosed with HIV at an earlier stage.

Comparing first-line antiretroviral therapies for HIV

The efficacy and safety of ART have greatly improved with the newer drug classes of antiretrovirals.

Increased HIV testing linked to earlier diagnosis in men who have sex with men

Researchers analyzed data from 21 jurisdictions conducting HIV incidence surveillance from 2007 to 2013.

Immediate antiretroviral therapy may reduce infection-related cancer in HIV

Patients with HIV infection with immediate access to antiretroviral therapy may have a reduced risk of infection-related cancer.

Efficacy of distributing HIV self-tests via Grindr

Free self-test kits were advertised among a population of high-risk MSM.

Early ART lowers risk of HIV-1 infection among sexual partners

Researchers observed 78 HIV-1 among partners, with an annual incidence of 0.9%.

Injectable oxymorphone, syringe sharing lead to HIV outbreak

The use of injectable, extended-release oxymorphone and syringe sharing was linked to an outbreak of HIV infections in Indiana.

HIV viral load linked to liver fibrosis

Patients with HIV infection and elevated viral load are likely to progress to advanced hepatic fibrosis.

Perinatal HIV exposure has negative psychosocial consequences

Children who were perinatally exposed to HIV are more likely to struggle with psychosocial adjustment during childhood and adolescence.

Pregnant women with HIV retained in care

Many women were found to have poor postpartum virologic control.

Posthysterectomy Pap testing may benefit women with HIV

More than 30% of women with HIV and no prehysterectomy had abnormal Pap test results.

HIV, STI rates elevated among young MSM

The relationship between HIV and STI rates and race/ethnicity and partner characteristics should be considered in future HIV intervention.

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