Combination ART may prevent progressive brain injury in HIV patients
Post-seroconversion brain morphology can occur in HIV patients, but aviremia maintenance via cART can slow of prevent brain injuries.
Patients with HIV had reduced brain volume and poorer cognitive performance but changes over time were similar to those in controls, according research published in JAMA Neurology.
HIV-associated neurocognitive disorders (HAND) affect up to 40% of patients with HIV regardless of effective viral suppression. Although HAND is common, progressive worsening is not and it remains unclear what role viral suppression plays.
To detect evidence of ongoing brain atrophy changes in brain volumes, shown using magnetic resonance imaging (MRI) scans and neuroimaging processing methods, and cognitive function assessed with standard neurophysiological tests over 2 years were compared in HIV-positive individuals treated with combination antiretroviral therapy and aviremic with demographically similar HIV-negative controls.
Sanford R, Fellows LK, Ances BM, Collins L. Association of brain structure changes and cognitive function with combination antiretroviral therapy in HIV-positive individuals. [published online November 13, 2017]. JAMA Neurol. doi:10.1001/jamaneurol.2017.3036