Is there any evidence that changing a patient’s cephalexin dose from 500 q.i.d. to 1,000 b.i.d. has decreased efficacy in terms of infection (i.e., cellulitis) control? — Jen Flannery, PA-C, Seattle

The recommended dose of cephalexin for uncomplicated skin and soft-tissue infection is 250 mg every six hours or 500 mg every 12 hours. Efficacy is not affected by changing dosage schedule. In severe infection the dosage can be doubled. — Claire Babcock O’Connell, MPH, PA-C (155-1)