Is there any relationship between calcium pyrophosphate dihydrate disease (pseudogout) and vitamin D deficiency? — Joy Green-Hadden, DNP, RN, FNP-BC, Aurora, Colo.

Pseudogout is a form of arthritis that develops in people with calcium pyrophosphate crystal deposition disease. The condition is caused by the buildup of calcium pyrophosphate dihydrate crystals within a joint, and symptoms can mimic gout (caused by urate crystals).

A review of literature on both vitamin D deficiency and pseudogout shows no direct connection between the two conditions. There is an indirect link through the parathyroid, in that vitamin D levels help regulate parathyroid activity, which affects calcium levels. Pseudogout is a rare adverse reaction to surgical parathyroidectomy. Theoretically, excessively high levels of vitamin D would decrease the function of the parathyroid. — Rebecca H. Bryan, APRN, CNP (161-1)

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