I have had great success using promethazine (Phenergan) along with a migraine medication for patients who have migraine with nausea. Other than fatigue, are there any concerns over use of this combination? — JAMES MULLONEY, FNP, Yorktown, Ind.

Except for the contraindications of each drug, there are no specific concerns with this combination. I have found a Phenergan/Benadryl (diphenhydramine) “cocktail” to be very effective, often even without other migraine medications. — Sherril Sego, FNP-C, DNP (145-4)