What effect do statins – specifically lovastatin (Altoprev, Mevacor) and simvastatin (Zocor) – have on calcium channel blockers (CCBs)? — Kathleen Mahoney, ANP, PhD, Philadelphia

The combined use of a CCB (e.g., amlodipine [Norvasc]) with simvastatin has the potential to increase the serum concentration of simvastatin. Concomitant use of amlodipine with simvastatin should be avoided whenever possible. I have found no interaction between CCBs and lovastatin. — Abimbola Farinde, PharmD, Staff Pharmacist, Clear Lake Regional Medical Center, Webster, Tex. (186-1)

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