HealthDay News — A novel handheld mHealth platform (Vivio) can accurately detect cardiac dysfunction in anthracycline-exposed childhood cancer survivors, according to a study published online June 21 in Clinical Cancer Research.

Saro H. Armenian, DO, MPH, from the City of Hope in Duarte, Calif., and colleagues conducted a cross-sectional study to compare the accuracy of Vivio and echocardiography  for assessment of cardiac function (left ventricular ejection fraction [EF]) in childhood cancer survivors with cardiac magnetic resonance (CMR) imaging. Concurrent evaluation of EF was performed using Vivio, 2-dimensional echocardiography, and CMR. One hundred ninety-one consecutive survivors participated in the study. Their median anthracycline dose was 225 mg/m².

The researchers found that echocardiography overestimated mean EF by 4.9%; in linear regression analysis, a proportional bias was confirmed when compared with CMR. No difference was seen between mean EF derived from Vivio and CMR (−0.2%; P = 0.68). Compared with CMR, the detection of cardiac dysfunction via echocardiography was poor (Echo EF <45%: sensitivity, 14.3%; Echo EF <50%: sensitivity, 28.6%). Vivio-based measurements had considerably better sensitivity (EF <45% or EF <50%: sensitivity, 85.7%).

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“This accessible technology has the potential to change the day-to-day practice of clinicians caring for the large number of patients diagnosed with cardiac dysfunction and heart failure each year, allowing real-time monitoring and management of their disease without the lag-time between imaging and interpretation of results,” the authors write.

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Several authors disclosed financial ties, including ownership interests, to biotechnology companies.

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