Level 1: Likely reliable evidence
The Chlamydia Rapid Test uses a monoclonal antibody-coated test strip on vaginal swab samples, with results available in <30 minutes. This test is accurate for diagnosing or ruling out chlamydia genital infection in women, based on a diagnostic cohort study of 1,458 eligible patients aged 16-54 years who presented to three clinics in the United Kingdom (BMJ. 2007;335:1190-1194; full-text available online without charge at: www.bmj.com/cgi/content/full/335/7631/1190. Accessed February 4, 2008). The analysis included 1,349 women (92.5%) who had valid samples for the rapid test and the reference standard (using self-collected vaginal swabs); 110 women (8.15%) had chlamydia according to the reference standard (polymerase chain reaction).
The Chlamydia Rapid Test had 82.7% sensitivity, 98.8% specificity, 85.8% positive predictive value, and 98.5% negative predictive value for chlamydia. Outcomes were similar comparing patient-collected and clinician-collected specimens. The Chlamydia Rapid Test is not yet available in the United States. It is available for purchase in some developing countries and is expected to be available in the United Kingdom this year.