It is inaccurate to say that dehydroepiandrosterone (DHEA) (Alternative Meds Update, July 2010) should not be used when prostate cancer is a concern. The idea that androgenic hormones have detrimental effects on prostate cancer stems from some poorly done research published in the mid-20th century by Dr. Charles Huggins. Current literature does not support the previously made claims that circulating androgen levels somehow increase the risk of prostate cancer. A 2008 study showed no statistical relationship between serum testosterone levels and risk of prostate cancer (J Natl Cancer Inst. 2008;100:170-183).—ANTHONY BALCHUNAS, MS, PA-C, Waco, Tex. (143-15)