A new patient’s former clinician prescribed bupropion (Wellbutrin) for the first seven days of each month. Is this common? What is the advantage of this method?
—Suzanne R. Martin, FNP-C, Howell, Michigan.

I found no reason in the literature for using a selective serotonin reuptake inhibitor (SSRI) only seven days per month. I would discontinue this practice and use an antidepressant on a daily basis if indicated. The only time an SSRI might not be used on a daily basis is for treatment of premenstrual syndrome, in which case it can be given during the two-week luteal phase of the menstrual cycle (Obstet Gynecol. 2002;100:1219-1229).
—Julee B. Waldrop, MS, PNP (100-22)

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