Both exercise and psychotherapy are cited as being equally effective as pharmacotherapy in the treatment of depression (“Adult depression: Treating by subtype for success,” February 2010). They are also more effective in preventing relapse and recurrence. It is unfortunate that these options are presented almost as an afterthought to an article about how to prescribe drugs. Simple interventions by clinicians can go a long way in helping patients understand and manage their moods in reaction to the circumstances of their lives. Depression can be treated in a comprehensive and effective way for the benefit of all concerned.—Marian Stuart, PhD, Morristown, N.J. (137-17)