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ORLANDO — Mometasone furoate nasal spray can effectively reduce nasal congestion symptoms associated with seasonal allergic rhinitis, confirming current guidelines, according to research presented at the 2018 American Academy of Allergy Asthma & Immunology/World Allergy Organization Joint Congress.
Researchers conducted a post hoc cumulative responder analysis of 2 clinical studies examining the efficacy of mometasone furoate nasal spray in reducing moderate-to-severe nasal congestion in people with seasonal allergic rhinitis.
Patients were 12 years or older and had a 2-year history of seasonal allergic rhinitis with a positive skin test. They were randomly assigned to receive either mometasone furoate nasal spray or placebo treatment (n=344 and n=340, respectively).
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Primary end point was the change in nasal congestion from baseline, with treatment response ranging from 0% to 90%. Researchers evaluated improvement at 10% intervals, with further analysis of >30% and >50% reductions.
Within >30% response, more patients treated with mometasone furoate experienced a response to treatment compared with those treated with placebo (36.6% vs 19.4%); rates were similar with >50% response (13.4% vs 6.5% of mometasone furoate-treated patients vs placebo-treated patients).
Patient response to mometasone furoate was increased during the second week of treatment, with no difference between morning and evening nasal congestion scores.
“[Mometasone furoate nasal spray] is effective in patients with [seasonal allergic rhinitis] and moderate-to-severe nasal congestion,” the researchers concluded.
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Reference
Urdaneta ER, Tunceli K, Gates G. Mometasone furoate nasal spray relieves moderate-severe nasal congestion in patients with seasonal allergic rhinitis: a responder analysis. Presented at: AAAAI/WAO Joint Congress; March 2-5, 2018; Orlando, FL. Abstract 217.
This article originally appeared on Pulmonology Advisor
