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ORLANDO – Chronic kidney disease (CKD) is more prevalent among adults with type 2 diabetes compared with adults with type 1 diabetes, according to results presented at the American Diabetes Association’s 78th Scientific Sessions held in Orlando, Florida, June 22-26, 2018.
The results also indicated that, while uncommon, macroalbuminuria significantly predicted estimated glomerular filtration rate (eGFR) decline in those with both type 1 and type 2 diabetes.
The study included participants with type 1 diabetes (n=48,036) and type 2 diabetes (n=1,461,915) from a clinical laboratory database maintained by LabCorp®. The researchers calculated rates of eGFR decline for participants with ≥3 eGFR results over at least a 1-year period. They defined CKD as eGFR <60 mL.min/1.73 m2 or albumin-to-creatinine ratio ≥30 mg/g.
The results showed that participants with type 2 diabetes had a higher prevalence of CKD compared with participants with type 1 diabetes (44.3% vs 31.6%, P <.001). The proportion of participants who were classified as high or very high risk for CKD was also higher among those with type 2 diabetes (17.8% vs 12.0%, P <.001).
Macroalbuminuria, defined as an albumin-to-creatinine ratio >300, was not prevalent in either group, occurring in 7.8% of participants with type 1 diabetes and in 8.3% of participants with type 2 diabetes.
Whereas median eGFR decline (mL/min/year) was low in the overall population (-0.6 for type 1 diabetes; -0.8 for type 2 diabetes), it was high for participants with macroalbuminuria, with median annual rates of decline of -3.80 for type 1 and -3.58 for type 2 diabetes.
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Cressman M, Ennis JL, Goldstein BJ, et al. CKD prevalence and risk are higher in adults with type 2 vs. type 1 diabetes — an assessment of 1.5 million patients recently evaluated in U.S. clinical practices. Presented at: ADA 2018 78th Scientific Sessions; June 22-26, 2018; Orlando, FL. Poster 544.
This article originally appeared on Endocrinology Advisor