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ORLANDO — In patients with type 2 diabetes, MEDI0382 safely and effectively normalizes fasting/postprandial blood glucose and significantly reduces body weight, according to results presented at the American Diabetes Association’s 78th Scientific Sessions held in Orlando, Florida, June 22-26, 2018.
The study included participants with type 2 diabetes and body mass index (BMI) of 27 to 40 kg/m2 (n=51). Participants were randomly assigned to receive daily subcutaneous MEDI0382 200 μg or placebo (NCT02548585).
Participants who took MEDI0382 had significantly reduced fasting glucose (change from baseline at day 41, −49.9 vs −19.2 mg/dL; P <.0001) and postprandial glucose in a mixed-meal tolerance test (percent change from baseline in glucose area under the curve0-4h, −32.8 vs −10.2; P <.0001). There was no increase in hypoglycemia.
In participants who took MEDI0382, glycated hemoglonin A1c (HbA1c) levels decreased −0.9% compared with −0.6% with placebo (P =.0004). Participants in the MEDI0382 group lost 3.8 kg (1.7 kg more than the placebo group), with 92% of MEDI0382 participants losing >2 kg. MEDI0382 participants had a −4.2 mean reduction in ambulatory systolic blood pressure compared with −1.5 mmHg with placebo.
The most common treatment-related adverse events were decreased appetite, vomiting, and headache, which were reported by 20 participants in the MEDI0382 group and 15 in the placebo group.
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Ambery P, Stumvoll MW, Posch MG, et al. Robust glucose control and weight loss after six weeks of treatment with MEDI0382, a balanced GLP-1/glucagon receptor dual agonist, in patients with type 2 diabetes. Presented at the ADA 2018 78th Scientific Sessions; June 22-26, 2018; Orlando, Florida. Poster 1067.
This article originally appeared on Endocrinology Advisor