HealthDay News — For patients with diabetes subsequently diagnosed and hospitalized with COVID-19, use of a sodium-glucose cotransporter-2 (SGLT2) inhibitor before COVID-19 infection is associated with lower COVID-19-related adverse outcomes, according to a systematic review and network meta-analysis published in JAMA Network Open.

Zheng Zhu, from the Shengli Clinical Medical College of Fujian Medical University in Fuzhou, China, and colleagues examined the association between COVID-19-related adverse outcomes and 8 antihyperglycemic drugs in patients with diabetes subsequently diagnosed and hospitalized with COVID-19 in a review and meta-analysis. Data were included from 31 observational studies, with 3,689,010 patients with diabetes hospitalized for COVID-19.

Compared with insulin, dipeptidyl peptidase-4 (DPP4) inhibitors, secretagogues, and glucosidase inhibitors, the SGLT2 inhibitors were associated with relatively lower risks for adverse outcomes (log of odds ratios [95% credible intervals], 0.91 [0.57 to 1.26], 0.61 [0.28 to 0.93], 0.37 [0.02 to 0.72], and 0.50 [0.00 to 1.01]). SGLT-2 inhibitors were associated with the lowest probability for adverse outcomes followed by glucagon-like peptide 1 (GPL1) receptor agonists and metformin based on the surface under the cumulative ranking curves value (6%, 25%, and 28%, respectively). The study was deemed reliable in a sensitivity analysis.

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“Our results suggest that compared with other diabetes drugs, the use of SGLT2 inhibitors before COVID-19 infection in patients with diabetes was associated with a lower incidence of adverse outcomes after infection, which may be associated with improving blood glucose level, blood pressure, body weight, and lipid metabolism,” the authors wrote.

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