The risk for spontaneous abortion is not increased following exposure to nonsteroidal anti-inflammatory drugs (NSAIDs), affirmed Amalia Levy, MPH, PhD, and associates in CMAJ.

Spontaneous abortion is the most common complication of pregnancy and NSAIDs are widely used by pregnant women, but published data are inconsistent regarding the risk of spontaneous abortion following NSAID exposure.

Levy and coauthors analyzed data from a cohort of 65,457 women who conceived between January 2003 and December 2009. A total of 6,508 (9.9%) experienced spontaneous abortion, and 4,495 (6.9%) of the pregnant women were exposed to NSAIDs during the study period. 

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NSAID exposure was not an independent risk factor for spontaneous abortion, and the investigators found no increased risk for specific NSAIDs, with the exception of a significantly increased risk with exposure to indomethacin (Indo-Lemmon, Indocin).

Clinicians might need to advise women who are of child-bearing age about even more aspects of pregnancy: A study in Fertility & Sterility by Jessica Illuzzi, MD, and colleagues revealed that in a sample of 1,000 women aged 18 to 40 years across the United States, one-third of the subjects were unaware of the adverse implications of sexually transmitted infections, obesity, or irregular menses for procreative success.


  1. Daniel S et al. CMAJ. 2013; doi:10.1503/cmaj.130605.