Providers can prevent acute kidney injury (AKI) in their patients hospitalized for unrelated conditions by monitoring their kidney function tests for abnormal results, according to two meta-analyses published online ahead of print in the American Journal of Kidney Diseases. 

Lower eGFRs and higher ACRs were stronger risk factors for AKI than being older, male, African-American or having diabetes in both studies, which were published by authors with the Chronic Kidney Disease Prognosis Consortium and analyzed data from more than 1.3 million patient records that included 18,567 patients who developed AKI. 

On May 3, lead author Morgan E. Grams, MD, PhD, and colleagues published their report on estimated glomerular filtration rate (eGFR), albumin-creatinine ratio (ACR), age, sex, and race (African American and white) as risk factors for AKI. They found that reduced eGFR and increased ACR are consistently stronger as risk factors for AKI than are associations of AKI with age, sex, and race.

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On May 11, lead author Matthew T. James, MD, PhD, and colleagues published their report on whether eGFR and ACR remain risk factors for AKI in the presence and absence of diabetes mellitus and hypertension, both of which are known risk factors for AKI. They concluded that lower eGFRs and higher ACRs are associated with higher risks for AKI among individuals with or without either diabetes or hypertension.