HealthDay News — Women are at increased risk for heart failure and death after first-time myocardial infarction (MI), according to a study published online in Circulation.

Justin A. Ezekowitz, MBBCh, from the University of Alberta in Edmonton, Canada, and colleagues examined the incidence, angiographic findings, treatment, and clinical outcomes of 45,064 patients (30.8% women) hospitalized with a primary diagnosis of first-time MI between 2002 and 2016 (54.9% non-ST-segment elevation MI [NSTEMI] and 45.1% ST-segment elevation MI [STEMI]).

The researchers found that compared with men, women were older, had more comorbidities, and had lower rates of diagnostic angiography. Among patients with STEMI and NSTEMI, women had a higher unadjusted rate of in-hospital mortality than men (STEMI, 9.4% vs 4.5% NSTEMI, 4.7% vs 2.9%). The difference remained significant after adjustment in STEMI patients (adjusted odds ratio, 1.42; 95% confidence interval, 1.24 to 1.64) but not in NSTEMI patients (adjusted odds ratio, 0.97; 95% confidence interval, 0.83 to 1.13). After discharge more women than men developed heart failure after STEMI (22.5% vs 14.9%) and NSTEMI (23.2% vs 15.7%). Across the years, these differences remained similar.

“There are gaps across diagnosis, access, quality of care, and follow-up for all patients, so we need to be vigilant, pay attention to our own biases and to those most vulnerable to ensure that we have done everything possible in providing the best treatment,” a coauthor said in a statement.


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