(HealthDay News) — Restarting anticoagulation therapy may be cost-effective for patients with a predicted 1-year venous thromboembolism (VTE) risk of 17.5% or higher, according to a study published in the Journal of Thrombosis and Haemostasis.

Mark Monahan, from the University of Birmingham in the United Kingdom, and colleagues examined the long-term cost-effectiveness of using a decision rule for restarting anticoagulation therapy vs no extension of therapy based on a patient’s risk of further unprovoked VTE. A Markov patient-level simulation model was developed, which adopted a lifetime time horizon from the perspective of the UK National Health Service/Personal Social Services.

The researchers found that if decision makers are willing to pay up to £20,000 per quality-adjusted life-year gained, treating patients with a predicted 1-year VTE risk of 17.5% or higher may be cost-effective. The model was highly sensitive to overall parameter uncertainty, warranting caution in choosing the optimal decision rule on the grounds of cost-effectiveness. Anticoagulation therapy disutility and mortality risks were highly influential for driving the results in univariate sensitivity analyses.

Continue Reading

“This represents the first economic model to consider the use of a decision rule for restarting therapy for unprovoked VTE patients,” the authors write. “Better data are required to predict long-term bleeding risks on therapy in this patient group.”


  1. Monahan M, Ensor J, Moore D, Fitzmaurice D, Jowett S. Economic evaluation of strategies for restarting anticoagulation therapy after a first event of unprovoked venous thromboembolism. J Thromb Haemost. 2017 May 18. doi:10.1111/jth.13739