(HealthDay News) — Statin use is associated with a decreased risk of community-acquired Staphylococcus aureus bacteremia (CA-SAB), particularly in long-term users, according to a study published in the October issue of Mayo Clinic Proceedings.
Jesper Smit, MD, PhD, from Aalborg University Hospital in Denmark, and colleagues used population-based medical registries to identify 2,638 adults with first-time CA-SAB and 26,379 population controls matched for age, sex, and residence in northern Denmark (Jan 1, 2000, through Dec 31, 2011). Statin users were characterized as current users (new or long-term use), former users, and nonusers.
The researchers found that compared with nonusers, current statin users experienced markedly decreased risk of CA-SAB (adjusted odds ratio [OR], 0.73; 95% confidence interval, 0.63 to 0.84). The adjusted OR was 0.96 (95% confidence interval, 0.6 to 1.51) for new users, 0.71 (95% confidence interval, 0.62 to 0.82) for long-term users, and 1.12 (95% confidence interval, 0.94 to 1.32) for former users, all vs nonusers. Increasing intensity of statin use was associated with decreased CA-SAB risk compared with nonusers (adjusted OR, 0.84 [95% confidence interval, 0.68 to 1.04] for current users with daily dosages <20 mg/day; 0.71 [95% confidence interval, 0.58 to 0.87] for 20 to 39 mg/day, and 0.63 [95% confidence interval, 0.49 to 0.81] for 40 mg/day or more). However, there were no differences in CA-SAB risk with increases in duration of statin use.
“Our results warrant confirmation in other settings and study designs, and the biological mechanisms by which statin treatment may protect against CA-SAB should be explored further,” conclude the authors.
Several authors disclosed ties to the pharmaceutical industry.
Smit J, López-Cortés LE, Thomsen RW, et al. Statin use and risk of community-acquired Staphylococcus aureus Bacteremia: A population-based case-control study. Mayo Clin Proc. 2017 Oct;92(10). doi: 10.1016/j.mayocp.2017.07.008