HealthDay News — Treatment with a pill combining low doses of three antihypertensive drugs results in an increased proportion of patients with mild-to-moderate hypertension achieving their target blood pressure (BP), according to a study published in the Aug. 14 issue of the Journal of the American Medical Association.

Ruth Webster, PhD, from the University of New South Wales in Sydney, and colleagues conducted a randomized trial of a low-dose triple BP therapy vs usual care for adults with hypertension requiring initiation or escalation of antihypertensive therapy. Patients enrolled from 11 urban hospital clinics in Sri Lanka were randomized to a once-daily fixed-dose triple combination pill (20 mg telmisartan, 2.5 mg amlodipine, and 12.5 mg chlorthalidone; 349 patients) or usual care (351 patients).

The researchers found that the proportion of patients achieving target BP was increased with the triple combination pill vs usual care at six months (70 vs 55%; risk difference, 12.7%). At 6 months, the mean systolic/diastolic BP was 125/76 vs 134/81 mm Hg for the triple combination pill vs usual care (adjusted difference in post-randomization BP over entire follow-up: −9.8 and −5.0 mm Hg for systolic and diastolic BP, respectively). Overall, in 255 patients there were 419 adverse events (38.1% for triple combination pill vs 34.8% for usual care).


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“Use of such medication as initial therapy or to replace monotherapy may be an effective way to improve BP control,” the authors write.

Two authors disclosed financial ties to George Health Enterprises, which has received investment funds to develop fixed-dose combination products containing aspirin, statin, and blood pressure-lowering drugs and has submitted a patent for the treatment of hypertension.

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