Duration-dependent beneficial effects of metformin, sulfonylurea, and thiazolidinedione use on COPD exacerbation have been observed in patients with COPD and diabetes.
Triple therapy with budesonide/glycopyrrolate/formoterol fumarate may reduce the risk of death compared with glycopyrrolate/formoterol fumarate in patients with COPD.
The adjusted rate of decline in predose trough FEV1 during 52 weeks in theResearchers used a substudy of the Phase 3 ETHOS study to evaluate lung function decline in patients with inhaled corticosteroid-containing therapies vs glycopyrrolate/formoterol fumarate metered dose inhaler.
Once-daily revefenacin when administered via a jet nebulizer with formoterol was well tolerated and associated with greater lung function response compared with formoterol alone in patients with COPD.
Implementation of the Hospital Readmission Reduction Program was associated with a decrease in 30-day readmissions in patients with COPD following their hospital discharge.
Recommendations are presented for the use of noninvasive ventilation for patients with COPD and chronic hypercapnia in an American Thoracic Society clinical practice guideline.
Treatment with dupilumab led to significant improvements in lung function by 16 weeks and up to 24 weeks in patients with chronic rhinosinusitis with nasal polyps and comorbid asthma plus clinical features of COPD.
The FDA has approved Breztri Aerosphere (budesonide/glycopyrrolate/formoterol fumarate; AstraZeneca) for the maintenance treatment of chronic obstructive pulmonary disease.
In an American Thoracic Society clinical practice guideline, recommendations are presented for the pharmacologic management of patients with chronic obstructive pulmonary disease (COPD) complaining of exercise intolerance or dyspnea.
Practitioners can play a vital role in providing education and training on correct inhalation techniques to enhance therapeutic benefit and optimal medication delivery. Overall, the goal for the provider is to be confident when educating patients on proper use of inhalation technique, emphasize the importance of medication adherence, and maintain follow-up appointments.
In patients with COPD and hypercapnia, the use of home noninvasive positive pressure ventilation compared with no device was significantly associated with improved clinical outcomes but no significant differences in quality of life.
