HealthDay News — For patients with suboptimally controlled type 1 diabetes, day-and-night hybrid closed-loop insulin delivery improves glucose control compared with sensor-augmented pump therapy, according to a study published online Oct. 3 in The Lancet. The research was published to coincide with the annual meeting of the European Association for the Study of Diabetes, held from Oct. 1 to 5 in Berlin.

Martin Tauschmann, MD, from the University of Cambridge in the United Kingdom, and colleagues randomly assigned participants aged 6 years and older treated with an insulin pump and with suboptimal glycemic control to receive hybrid closed-loop therapy (46 patients) or sensor-augmented pump therapy (40 patients) during 12 weeks of free living.

The researchers found that glucose was within the target range of more than 3.9 mmol/L and less than 10.0 mmol/L for a significantly greater proportion of time in the closed-loop group (65% vs 54%) compared with the control group. Hemoglobin A1c (HbA1c) values reduced from a screening value of 8.3% to 8.0% after the 4-week run-in and to 7.4% after the 12-week intervention period in the closed-loop group. In the control group, the corresponding HbA1c values were 8.2%, 7.8%, and 7.7%. There was a significantly greater reduction in HbA1c percentages in the closed-loop group (mean difference in change, 0.36%).

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“Hybrid closed-loop insulin delivery improves glucose control while reducing the risk of hypoglycemia across a wide age range in patients with suboptimally controlled type 1 diabetes,” the authors write.

Several authors disclosed financial ties to the pharmaceutical and medical device industries.

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