HealthDay News — Supplementation with vitamin D3 or omega-3 fatty acids does not result in a significant difference in change in estimated glomerular filtration rate (eGFR) at 5 years vs placebo among adults with type 2 diabetes, according to a study published online Nov. 8 in the Journal of the American Medical Association. The research was published to coincide with Kidney Week, the annual meeting of the American Society of Nephrology, held from Nov. 5 to 10 in Washington, D.C.

Ian H. de Boer, MD, from the University of Washington in Seattle, and colleagues conducted a randomized trial among 1312 adults with type 2 diabetes. Participants were randomly assigned to receive vitamin D3 and omega-3 fatty acids, vitamin D3 and placebo, placebo and omega-3 fatty acids, or 2 placebos (370, 333, 289, and 320 participants, respectively) for 5 years; 71% completed the study.

The researchers found that from baseline to year 5, the mean change in eGFR was −12.3 vs −13.1 mL/min/1.73 m² with vitamin D3 vs placebo (difference, 0.9; 95% confidence interval, −0.7 to 2.5). The mean change in eGFR was −12.2 vs −13.1 mL/min/1.73 m² with omega-3 fatty acids vs placebo (difference, 0.9; 95% confidence interval, −0.7 to 2.6). No significant interaction was seen between the 2 interventions.

“These results suggest that neither vitamin D nor omega-3 fatty acids have appreciable kidney benefits among the broad population of patients with diagnosed type 2 diabetes,” the authors write.

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Several authors disclosed financial ties to the pharmaceutical industry; one author disclosed holding a patent pending on a measurement of bioavailable vitamin D.

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