HealthDay News — Remission of type 2 diabetes following bariatric surgery peaks at 20% total weight loss (TWL), according to study findings published in Diabetes Care.

Douglas Barthold, PhD, from the University of Washington in Seattle, and colleagues assessed the amount of weight loss necessary to achieve initial remission of type 2 diabetes mellitus (T2DM) following bariatric surgery. The analysis included 5928 individuals (73% female; mean age, 49.8 years; mean body mass index, 43.8) who had bariatric surgery (57% Roux-en-Y gastric bypass), with an average follow-up of 5.9 years.

The researchers found that 71% of patients experienced initial remission of T2DM (mean time to remission, 1.0 year). Patients were more likely to remit with each 5% increase in TWL until 20% TWL (hazard ratio range, 1.97 to 2.92) versus those with 0% to 5% TWL. Patients with TWL >25% had a likelihood of initial remission similar to those with 20% to 25% TWL. Even among patients using insulin at the time of surgery, those who achieved >20% TWL were more likely to achieve initial T2DM remission versus patients with 0% to 5% TWL.


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“Our findings can be used to help providers and patients discuss realistic expectations for weight loss following bariatric surgery and how this will affect their T2DM remission,” the authors write.

One author disclosed financial ties to the pharmaceutical industry.

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