HealthDay News — Individuals with type 2 diabetes (T2D) are at higher risk for sustaining an incident vertebral fracture (VF) compared with individuals without T2D, according to a review published online Oct. 28 in Diabetes Care.
Fjorda Koromani, from the Erasmus University Medical Center in Rotterdam, Netherlands, and colleagues conducted a systematic literature review to evaluate the relationship between T2D and VFs.
Based on 15 included studies (852,705 men and women), the researchers found that individuals with T2D had a lower risk for prevalent VFs (odds ratio, 0.84; 95% confidence interval [CI], 0.74 to 0.95), but an increased risk for incident VFs (odds ratio, 1.35; 95% CI, 1.27 to 1.44). Using individual data for 19,820 participants, the risk for nonvertebral fractures was higher in those with both T2D and VFs vs those without T2D or VFs (hazard ratio [HR], 2.42; 95% CI, 1.86 to 3.15]) or with either VFs (HR, 1.73; 95% CI, 1.32 to 2.27) or T2D (HR, 1.94; 95% CI, 1.46 to 2.59) alone. Additionally, increased mortality was seen with individuals with both T2D and VFs vs individuals without T2D and VFs (HR, 2.11; 95% CI, 1.72 to 2.59) or with VFs alone (HR, 1.84; 95% CI, 1.49 to 2.28) or, to a lesser extent, T2D alone (HR, 1.23; 95% CI, 0.99 to 1.52).
“Based on our findings, individuals with T2D should be systematically assessed for presence of VFs, and, as in individuals without T2D, their presence constitutes an indication to start osteoporosis treatment for the prevention of future fractures,” the authors write.