HealthDay News — The magnitude of the association of diabetes with stroke risk varies by age, race, and sex, according to a study published online Aug. 7 in Diabetes Care.
Gargya Malla, MBBS, MPH, from the University of Alabama at Birmingham, and colleagues examined age, race, and sex differences in the diabetes-stroke association in the Reasons for Geographic and Racial Differences in Stroke Study. Data were included for 23,002 non-Hispanic black and white US adults aged ≥45 years without prevalent stroke at baseline from 2003 to 2007. Incident stroke events were examined through September 2017.
The researchers found that at baseline, the prevalence of diabetes was 19.1%. There were 1018 stroke events during follow-up. After multivariable adjustment, among adults aged <65 years, increased stroke risk was seen for white women (hazard ratio [HR], 3.72; 95% confidence interval [CI], 2.10 to 6.57), black women (HR, 1.88; 95% CI, 1.22 to 2.90), and white men (HR, 2.01; 95% CI, 1.27 to 3.27), but not black men (HR, 1.27; 95% CI, 0.77 to 2.10) with diabetes compared with those without diabetes. Among those aged ≥65 years, diabetes correlated with elevated stroke risk among white women but not black women (HR, 1.05; 95% CI, 0.74 to 1.48) and among black men but not white men (HR, 0.86; 95% CI, 0.62 to 1.21).
“These findings suggest that targeted efforts are necessary earlier in life for stroke prevention, particularly among adults with diabetes,” the authors write.
Two authors disclosed financial ties to Amgen.