HealthDay News — Increased dietary vitamin A seems to be associated with a reduced risk for incident cutaneous squamous cell carcinoma (SCC), according to a study published online July 31 in JAMA Dermatology.

Jongwoo Kim, MD, from the Warren Alpert Medical School of Brown University in Providence, Rhode Island, and colleagues examined vitamin A and carotenoid intake and SCC risk in the Nurses’ Health Study and Health Professionals Follow-Up Study.

The researchers observed a reduction in SCC risk with higher total vitamin A; the pooled multivariate hazard ratios were 0.97 (95% confidence interval [CI], 0.87 to 1.07) for quintile 2, 0.97 (95% CI, 0.80 to 1.17) for quintile 3, 0.93 (95% CI, 0.84 to 1.03) for quintile 4, and 0.83 (95% CI, 0.75 to 0.93) for quintile 5, compared with quintile 1 as a reference. Reductions in SCC risk were seen for higher intakes of retinol and some carotenoids: For the highest vs lowest quintiles of intake, the pooled hazard ratios were 0.88 (95% CI, 0.79 to 0.97) for total retinol, 0.86 (95% CI, 0.76 to 0.96) for beta cryptoxanthin, 0.87 (95% CI, 0.78 to 0.96) for lycopene, and 0.89 (95% CI, 0.81 to 0.99) for lutein and zeaxanthin.

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“Our data further support the contention that supplemental and dietary vitamin A may be beneficial in preventing SCC,” the authors write.

One author disclosed financial ties to the pharmaceutical industry.

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