Compared to placebo, treatment with ustekinumab resulted in a significantly greater proportion of adults with moderate to severe UC achieving clinical remission at week 44 (primary endpoint).
Vedolizumab (Entyvio; Takeda), an integrin receptor antagonist, was found to be superior to adalimumab (Humira; AbbVie), a tumor necrosis factor-alpha (TNFα) antagonist, in achieving clinical remission in patients with moderately to severely active ulcerative colitis (UC), according to results from a phase 3b head-to-head trial.
Children from lower-income households are more likely to report recent childhood gastrointestinal and respiratory illnesses but are less likely to miss any school days.
Sixty-three more cases of illness in a Salmonella outbreak linked to raw turkey products have been reported since Dec 21, 2018, bringing the total number to 279.
The microbiome of patients with systemic lupus erythematosus (SLE), particularly those with increased disease activity, has reduced taxonomic complexity,.
In older patients with inflammatory bowel disease, tumor necrosis factor alpha antagonist therapy and vedolizumab were found to be comparable with regard to both safety and effectiveness.
A team of investigators sought to identify the independent effects of hyperlipidemia and statin exposure on mortality, hepatic decompensation, and hepatocellular carcinoma in individuals with cirrhosis.
A recently published report describes the case of a 59-year-old male patient who experienced olmesartan-associated enteropathy (OAE) and highlights the importance of performing thorough medication reviews.
The combination of vancomycin and fecal microbiota transplantation was found to be superior to fidaxomicin or vancomycin in the treatment of patients with recurrent Clostridioides (formerly Clostridium) difficile infection (CDI), according to a study published in Gastroenterology. This randomized, single-center trial was designed to compare the efficacy of fecal microbiota transplantation with that of fidaxomicin…
In overweight and obese women, administering probiotics during the second trimester of pregnancy did not reduce the risk of gestational diabetes mellitus (GDM), according to a study published in Diabetes Care. Researchers conducted the Study of Probiotics In Gestation (SPRING), a prospective,double-blind, randomized controlled trial of probiotics vs placebo, to analyze whether probiotics prevented GDM…
Evaluation of a colorectal cancer (CRC) screening outreach strategy by mailed invitation for either fecal immunochemical test (FIT) or colonoscopy revealed that more primary care patients chose FIT, according to a study published in Preventive Medicine. Researchers conducted post-hoc analyses of data collected from a trial of CRC screening outreach. Patients who were not up-to-date with CRC screening…
Topline data from the Phase 3 STELLAR-4 trial showed that selonsertib, an investigational treatment for patients with compensated cirrhosis due to nonalcoholic steatohepatitis (NASH), was not associated with a significant improvement in fibrosis without worsening of NASH.
Conventional approaches to treatment of opioid-induced constipation include the use of treatment modalities that address non-opioid-related constipation as well as new medications that target the OIC mechanism of action.
