HealthDay News — Patients with celiac disease have an increased risk for inflammatory bowel disease (IBD) and vice versa, according to research published online May 13 in Gastroenterology.

Maria Ines Pinto-Sanchez, MD, from McMaster University in Hamilton, Ontario, Canada, and colleagues conducted a systematic review and meta-analysis to assess evidence for a correlation between celiac disease and IBD. The analysis included data from 65 studies.

The researchers observed an increased risk for celiac disease in patients with IBD vs controls, based on moderate-certainty evidence (relative risk, 3.96), and an increased risk for IBD in patients with celiac disease vs controls (relative risk, 9.88). In patients with celiac disease vs controls, there was low-certainty evidence for the risk for anti-Saccharomyces antibodies, a serologic marker of IBD (relative risk, 6.22). Low-certainty evidence was found for no difference in the risk for HLA-DQ2 or DQ8 in patients with IBD vs controls, while very low-certainty evidence was seen for an increased risk for anti-tissue transglutaminase in patients with IBD vs controls, which was not statistically significant.

“Although these results indicate a bidirectional association between celiac disease and IBD, it is unclear at this point whether screening of IBD should be performed in celiac disease and vice versa,” the authors write.


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Several authors disclosed financial ties to the pharmaceutical and nutrition industries.

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