HealthDay News — Transfusion of convalescent plasma is efficacious in patients with severe COVID-19, according to a study published online in The American Journal of Pathology.

Eric Salazar, MD, PhD, from Houston Methodist Hospital, and colleagues conducted a prospective, propensity score-matched study to examine the efficacy of COVID-19 convalescent plasma transfusion vs standard of care for severe and/or critical COVID-19. An interim analysis of 316 patients enrolled from March 28 to July 6, 2020, was performed.

Of the patients, 136 met a 28-day outcome and were matched to 251 nontransfused control patients with COVID-19. The researchers found that within 28 days, there was a significant reduction in mortality, specifically among patients transfused with plasma within 72 hours of admission, with an antispike protein receptor binding domain titer of ≥1:1,350.

“Our studies to date show the treatment is safe and, in a promising number of patients, effective,” a coauthor said in a statement. “While convalescent plasma therapy remains experimental and we have more research to do and data to collect, we now have more evidence than ever that this century-old plasma therapy has merit, is safe, and can help reduce the death rate from this virus.”


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One author disclosed financial ties to Regeneron.

Abstract/Full Text